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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for CEBPA
Z-value: 0.99
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Transcription factors associated with CEBPA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg19_v2_chr19_-_33793430_33793470 | -0.27 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_102668879 Show fit | 9.57 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr6_+_127898312 Show fit | 5.97 |
ENST00000329722.7
|
chromosome 6 open reading frame 58 |
|
| chr1_+_101185290 Show fit | 4.88 |
ENST00000370119.4
ENST00000347652.2 ENST00000294728.2 ENST00000370115.1 |
vascular cell adhesion molecule 1 |
|
| chr1_-_173020056 Show fit | 4.33 |
ENST00000239468.2
ENST00000404377.3 |
tumor necrosis factor (ligand) superfamily, member 18 |
|
| chr21_+_43619796 Show fit | 3.57 |
ENST00000398457.2
|
ATP-binding cassette, sub-family G (WHITE), member 1 |
|
| chr21_+_34775181 Show fit | 3.51 |
ENST00000290219.6
|
interferon gamma receptor 2 (interferon gamma transducer 1) |
|
| chr2_+_102721023 Show fit | 3.46 |
ENST00000409589.1
ENST00000409329.1 |
interleukin 1 receptor, type I |
|
| chr4_+_74606223 Show fit | 3.24 |
ENST00000307407.3
ENST00000401931.1 |
interleukin 8 |
|
| chr1_-_89531041 Show fit | 3.23 |
ENST00000370473.4
|
guanylate binding protein 1, interferon-inducible |
|
| chr1_-_173176452 Show fit | 3.15 |
ENST00000281834.3
|
tumor necrosis factor (ligand) superfamily, member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.8 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.9 | 5.4 | GO:0032730 | positive regulation of interleukin-1 alpha production(GO:0032730) |
| 0.7 | 4.9 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.2 | 4.5 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 1.1 | 4.3 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 0.9 | 3.6 | GO:0055099 | detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099) |
| 1.2 | 3.5 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 1.1 | 3.2 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 1.1 | 3.2 | GO:2000523 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.1 | 3.1 | GO:0042730 | fibrinolysis(GO:0042730) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.4 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 7.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.6 | 4.9 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.0 | 4.6 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 4.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 3.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.5 | 3.0 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
| 0.1 | 3.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 2.9 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 2.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 5.6 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.6 | 4.9 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 4.2 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 1.2 | 3.6 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 3.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.9 | 3.5 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.7 | 3.5 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.3 | 3.0 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.2 | 3.0 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 9.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 8.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 5.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 5.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 2.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 1.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.4 | 9.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 5.0 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 3.7 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.1 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 3.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 3.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 3.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 2.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |