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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for CEBPB
Z-value: 1.88
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Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg19_v2_chr20_+_48807351_48807384 | 0.57 | 3.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_139163491 Show fit | 11.25 |
ENST00000280612.5
|
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
|
| chr1_+_212782012 Show fit | 10.81 |
ENST00000341491.4
ENST00000366985.1 |
activating transcription factor 3 |
|
| chr11_-_102668879 Show fit | 10.58 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr15_-_80263506 Show fit | 10.37 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr15_+_89182178 Show fit | 10.32 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89182156 Show fit | 10.30 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr5_-_150473127 Show fit | 10.12 |
ENST00000521001.1
|
TNFAIP3 interacting protein 1 |
|
| chr15_+_89181974 Show fit | 8.92 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr5_-_141704566 Show fit | 7.99 |
ENST00000344120.4
ENST00000434127.2 |
sprouty homolog 4 (Drosophila) |
|
| chr6_+_127898312 Show fit | 6.96 |
ENST00000329722.7
|
chromosome 6 open reading frame 58 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 29.5 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.5 | 11.2 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 3.6 | 10.8 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.3 | 10.6 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.3 | 10.4 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 2.5 | 10.1 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 9.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 2.8 | 8.5 | GO:0006423 | cysteinyl-tRNA aminoacylation(GO:0006423) |
| 0.9 | 7.9 | GO:0001554 | luteolysis(GO:0001554) |
| 0.1 | 7.5 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 12.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 3.8 | 11.4 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.0 | 11.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.1 | 9.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 9.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 8.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 8.2 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 7.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 5.9 | GO:0005876 | spindle microtubule(GO:0005876) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 29.5 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 21.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 18.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.7 | 15.2 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.5 | 10.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.3 | 9.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 9.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 2.8 | 8.5 | GO:0004817 | cysteine-tRNA ligase activity(GO:0004817) |
| 0.4 | 7.2 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 6.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 10.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 10.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 5.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 5.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 4.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 4.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 2.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 24.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.4 | 16.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.4 | 14.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.3 | 9.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.7 | 7.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 6.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 6.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 5.0 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 3.9 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |