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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for CEBPE_CEBPD
Z-value: 0.70
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Transcription factors associated with CEBPE_CEBPD
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPE | hg19_v2_chr14_-_23588816_23588836 | -0.55 | 4.7e-03 | Click! |
| CEBPD | hg19_v2_chr8_-_48651648_48651648 | -0.22 | 3.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_169079823 Show fit | 3.29 |
ENST00000367813.3
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr12_+_102271129 Show fit | 3.03 |
ENST00000258534.8
|
DNA-damage regulated autophagy modulator 1 |
|
| chr15_+_45926919 Show fit | 2.84 |
ENST00000561735.1
ENST00000260324.7 |
sulfide quinone reductase-like (yeast) |
|
| chr3_-_158450231 Show fit | 2.80 |
ENST00000479756.1
|
retinoic acid receptor responder (tazarotene induced) 1 |
|
| chr3_-_158450475 Show fit | 2.43 |
ENST00000237696.5
|
retinoic acid receptor responder (tazarotene induced) 1 |
|
| chr2_+_102721023 Show fit | 2.25 |
ENST00000409589.1
ENST00000409329.1 |
interleukin 1 receptor, type I |
|
| chr1_+_144339738 Show fit | 1.96 |
ENST00000538264.1
|
Protein LOC642441 |
|
| chr16_-_84651647 Show fit | 1.76 |
ENST00000564057.1
|
coactosin-like 1 (Dictyostelium) |
|
| chr16_-_84651673 Show fit | 1.67 |
ENST00000262428.4
|
coactosin-like 1 (Dictyostelium) |
|
| chr5_-_121413974 Show fit | 1.59 |
ENST00000231004.4
|
lysyl oxidase |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPE_CEBPD
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.3 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.1 | 2.6 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.7 | 2.2 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.2 | 1.8 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.4 | 1.6 | GO:0072276 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 0.1 | 1.6 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.4 | 1.5 | GO:0009726 | detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099) |
| 0.1 | 1.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 1.4 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.1 | 1.4 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 3.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 2.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 1.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.5 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.2 | 1.0 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
| 0.1 | 0.9 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.6 | 2.2 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.0 | 1.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 1.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.4 | 1.6 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.3 | 1.6 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.5 | 1.5 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.2 | 1.4 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.1 | 1.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 1.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.6 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.9 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 2.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 2.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 1.6 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 1.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 1.4 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 1.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |