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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for CLOCK
Z-value: 0.62
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Transcription factors associated with CLOCK
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_69455855 Show fit | 1.02 |
ENST00000227507.2
ENST00000536559.1 |
cyclin D1 |
|
| chr3_-_123411191 Show fit | 0.88 |
ENST00000354792.5
ENST00000508240.1 |
myosin light chain kinase |
|
| chr6_+_7107999 Show fit | 0.75 |
ENST00000491191.1
ENST00000379938.2 ENST00000471433.1 |
ras responsive element binding protein 1 |
|
| chr3_-_127541679 Show fit | 0.66 |
ENST00000265052.5
|
monoglyceride lipase |
|
| chr21_-_31869451 Show fit | 0.64 |
ENST00000334058.2
|
keratin associated protein 19-4 |
|
| chrX_-_71526741 Show fit | 0.57 |
ENST00000454225.1
|
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 |
|
| chr6_+_7107830 Show fit | 0.56 |
ENST00000379933.3
|
ras responsive element binding protein 1 |
|
| chr6_+_7108210 Show fit | 0.52 |
ENST00000467782.1
ENST00000334984.6 ENST00000349384.6 |
ras responsive element binding protein 1 |
|
| chr9_+_706842 Show fit | 0.50 |
ENST00000382293.3
|
KN motif and ankyrin repeat domains 1 |
|
| chr15_+_98503922 Show fit | 0.48 |
ENST00000268042.6
|
arrestin domain containing 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CLOCK
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.8 | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells(GO:1903691) |
| 0.2 | 1.4 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 1.2 | GO:0070141 | response to UV-A(GO:0070141) |
| 0.2 | 1.0 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 0.1 | 0.9 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.1 | 0.9 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 0.6 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.0 | 0.6 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.2 | 0.5 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.1 | 0.5 | GO:0048698 | negative regulation of collateral sprouting in absence of injury(GO:0048698) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 0.9 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.7 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.1 | 0.6 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 0.6 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 0.6 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.6 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 0.4 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 1.4 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.1 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.1 | 1.0 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 0.9 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 0.8 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 0.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.6 | GO:0005502 | 11-cis retinal binding(GO:0005502) |
| 0.2 | 0.5 | GO:0102008 | cytosolic dipeptidase activity(GO:0102008) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.3 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.0 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.8 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.6 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 0.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.6 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |