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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for CREB3L1_CREB3
Z-value: 0.97
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Transcription factors associated with CREB3L1_CREB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3 | hg19_v2_chr9_+_35732312_35732332 | 0.71 | 7.9e-05 | Click! |
| CREB3L1 | hg19_v2_chr11_+_46299199_46299233 | 0.35 | 8.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_116692102 Show fit | 3.70 |
ENST00000359564.2
|
dermatan sulfate epimerase |
|
| chr3_-_156272924 Show fit | 2.05 |
ENST00000467789.1
ENST00000265044.2 |
signal sequence receptor, gamma (translocon-associated protein gamma) |
|
| chr2_-_69614373 Show fit | 1.69 |
ENST00000361060.5
ENST00000357308.4 |
glutamine--fructose-6-phosphate transaminase 1 |
|
| chr9_+_100818976 Show fit | 1.63 |
ENST00000210444.5
|
N-acetylneuraminic acid synthase |
|
| chr11_+_69455855 Show fit | 1.57 |
ENST00000227507.2
ENST00000536559.1 |
cyclin D1 |
|
| chr19_+_38810447 Show fit | 1.49 |
ENST00000263372.3
|
potassium channel, subfamily K, member 6 |
|
| chr6_-_90062543 Show fit | 1.46 |
ENST00000435041.2
|
ubiquitin-conjugating enzyme E2, J1 |
|
| chr6_+_31916733 Show fit | 1.43 |
ENST00000483004.1
|
complement factor B |
|
| chr22_+_38864041 Show fit | 1.31 |
ENST00000216014.4
ENST00000409006.3 |
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 |
|
| chr15_-_40213080 Show fit | 1.26 |
ENST00000561100.1
|
G protein-coupled receptor 176 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L1_CREB3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 2.4 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 2.3 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.2 | 2.0 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.0 | 1.9 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.2 | 1.8 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.1 | 1.8 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 1.6 | GO:0070141 | response to UV-A(GO:0070141) |
| 0.1 | 1.6 | GO:0009226 | nucleotide-sugar biosynthetic process(GO:0009226) |
| 0.0 | 1.6 | GO:0030818 | negative regulation of cAMP biosynthetic process(GO:0030818) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 2.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 1.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 1.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 1.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 1.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 1.0 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 1.0 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.7 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.3 | 1.9 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 0.3 | 1.8 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.1 | 1.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.7 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 1.6 | GO:0070567 | cytidylyltransferase activity(GO:0070567) |
| 0.0 | 1.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 1.4 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 1.4 | GO:0001848 | complement binding(GO:0001848) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.1 | 1.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.5 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 1.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.1 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 1.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.7 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 2.7 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.0 | 2.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.1 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 1.7 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 1.5 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 1.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.2 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.2 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |