ISMARA results: CREB3L2

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for CREB3L2

Z-value: 1.19

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Transcription factors associated with CREB3L2

Gene Symbol	Gene ID	Gene Info
CREB3L2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000182158.10	cAMP responsive element binding protein 3 like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CREB3L2	hg19_v2_chr7_-_137686791_137686821	0.25	2.3e-01	Click!

Activity profile of CREB3L2 motif

Sorted Z-values of CREB3L2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_89182156 Show fit	7.47	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 Show fit	7.31	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 Show fit	6.33	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr6_+_32811885 Show fit	3.87	ENST00000458296.1 ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1	TAPSAR1 Ensembl NCBI GeneCards UniProt NextProt Show fit PSMB9 Ensembl NCBI GeneCards UniProt NextProt Show fit	TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9
chr1_-_11120057 Show fit	2.84	ENST00000376957.2	SRM Ensembl NCBI GeneCards UniProt NextProt Show fit	spermidine synthase
chr15_-_40213080 Show fit	2.37	ENST00000561100.1	GPR176 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 176
chr20_-_22559211 Show fit	2.20	ENST00000564492.1	LINC00261 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 261
chr6_-_32811771 Show fit	2.17	ENST00000395339.3 ENST00000374882.3	PSMB8 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 8
chr3_-_123603137 Show fit	2.11	ENST00000360304.3 ENST00000359169.1 ENST00000346322.5 ENST00000360772.3	MYLK Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain kinase
chr6_+_32811861 Show fit	2.09	ENST00000453426.1	TAPSAR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TAP1 and PSMB8 antisense RNA 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB3L2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	21.1	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.1	6.0	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.1	3.2	GO:0006465	signal peptide processing(GO:0006465)
0.4	2.8	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.3	2.8	GO:0010918	positive regulation of mitochondrial membrane potential(GO:0010918)
0.1	2.6	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.2	2.5	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.2	2.5	GO:0015684	ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.3	2.4	GO:0017185	peptidyl-lysine hydroxylation(GO:0017185)
0.1	2.2	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)

Showing 1 to 10 of 107 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.7	GO:0015030	Cajal body(GO:0015030)
0.7	6.0	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	3.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.4	3.2	GO:0005787	signal peptidase complex(GO:0005787)
0.0	3.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	2.8	GO:0032592	integral component of mitochondrial membrane(GO:0032592)
0.1	2.5	GO:0030127	COPII vesicle coat(GO:0030127)
0.1	2.2	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	2.1	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	1.6	GO:0005758	mitochondrial intermembrane space(GO:0005758)

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.0	21.1	GO:0008859	exoribonuclease II activity(GO:0008859)
0.2	6.0	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	3.5	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.9	2.8	GO:0004766	spermidine synthase activity(GO:0004766)
0.1	2.8	GO:0005123	death receptor binding(GO:0005123)
0.3	2.5	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	2.5	GO:0042393	histone binding(GO:0042393)
0.5	2.4	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.1	2.2	GO:0001056	RNA polymerase III activity(GO:0001056)
0.2	2.1	GO:0004687	myosin light chain kinase activity(GO:0004687)

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	3.4	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	2.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	2.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	1.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.9	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.3	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	23.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.9	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2	3.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	3.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	3.2	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	2.8	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	2.7	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.1	2.2	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.0	2.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.8	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters

Showing 1 to 10 of 25 entries

Results for CREB3L2

Z-value: 1.19

Motif logo

Transcription factors associated with CREB3L2

Activity-expression correlation:

Activity profile of CREB3L2 motif

Sorted Z-values of CREB3L2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB3L2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: