ISMARA results: CXXC1

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for CXXC1

Z-value: 1.18

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Transcription factors associated with CXXC1

Gene Symbol	Gene ID	Gene Info
CXXC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000154832.10	CXXC finger protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CXXC1	hg19_v2_chr18_-_47813940_47814021	0.09	6.7e-01	Click!

Activity profile of CXXC1 motif

Sorted Z-values of CXXC1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_80915059 Show fit	4.27	ENST00000377104.3	SPRY2 Ensembl NCBI GeneCards UniProt NextProt Show fit	sprouty homolog 2 (Drosophila)
chr7_-_27213893 Show fit	3.61	ENST00000283921.4	HOXA10 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox A10
chr12_-_42983478 Show fit	2.76	ENST00000345127.3 ENST00000547113.1	PRICKLE1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prickle homolog 1 (Drosophila)
chr10_-_131762105 Show fit	2.65	ENST00000368648.3 ENST00000355311.5	EBF3 Ensembl NCBI GeneCards UniProt NextProt Show fit	early B-cell factor 3
chr7_+_8008418 Show fit	1.91	ENST00000223145.5	GLCCI1 Ensembl NCBI GeneCards UniProt NextProt Show fit	glucocorticoid induced transcript 1
chr13_-_33112823 Show fit	1.91	ENST00000504114.1	N4BP2L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEDD4 binding protein 2-like 2
chr1_+_63989004 Show fit	1.71	ENST00000371088.4	EFCAB7 Ensembl NCBI GeneCards UniProt NextProt Show fit	EF-hand calcium binding domain 7
chrX_-_125686784 Show fit	1.54	ENST00000371126.1	DCAF12L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	DDB1 and CUL4 associated factor 12-like 1
chr8_-_9008206 Show fit	1.51	ENST00000310455.3	PPP1R3B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory subunit 3B
chr11_+_7534999 Show fit	1.48	ENST00000528947.1 ENST00000299492.4	PPFIBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	PTPRF interacting protein, binding protein 2 (liprin beta 2)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CXXC1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.7	GO:0050667	homocysteine metabolic process(GO:0050667)
0.1	4.7	GO:0060065	uterus development(GO:0060065)
0.9	4.5	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
1.3	3.9	GO:0009107	lipoate biosynthetic process(GO:0009107)
0.1	3.0	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.7	2.8	GO:0051892	negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.3	2.4	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	2.3	GO:0016266	O-glycan processing(GO:0016266)
0.7	2.2	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.5	2.2	GO:0005986	sucrose biosynthetic process(GO:0005986)

Showing 1 to 10 of 361 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.5	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	3.3	GO:0032587	ruffle membrane(GO:0032587)
0.0	3.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	2.8	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	2.6	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	2.5	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2	2.2	GO:0005955	calcineurin complex(GO:0005955)
0.1	2.0	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	1.9	GO:0032039	integrator complex(GO:0032039)
0.0	1.7	GO:0031514	motile cilium(GO:0031514)

Showing 1 to 10 of 136 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.4	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.4	5.1	GO:0019826	oxygen sensor activity(GO:0019826)
1.3	3.9	GO:0070283	lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.0	3.8	GO:0042826	histone deacetylase binding(GO:0042826)
0.1	2.3	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5	2.2	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2	2.2	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	2.2	GO:0005179	hormone activity(GO:0005179)
0.1	2.1	GO:0043015	gamma-tubulin binding(GO:0043015)
0.2	2.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)

Showing 1 to 10 of 237 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.9	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	5.2	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.1	2.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	2.1	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	1.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	1.1	PID INSULIN PATHWAY	Insulin Pathway
0.0	1.1	PID BMP PATHWAY	BMP receptor signaling
0.0	1.1	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	0.9	PID ATM PATHWAY	ATM pathway

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	3.3	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.1	2.8	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	2.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	2.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	2.1	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	2.0	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	1.9	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	1.7	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	1.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway

Showing 1 to 10 of 74 entries

Results for CXXC1

Z-value: 1.18

Motif logo

Transcription factors associated with CXXC1

Activity-expression correlation:

Activity profile of CXXC1 motif

Sorted Z-values of CXXC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CXXC1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: