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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for DDIT3

Z-value: 0.41

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DNA damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_579143040.058.2e-01Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_33913708 0.81 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr10_-_116444371 0.69 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr14_-_92413353 0.61 ENST00000556154.1
FBLN5
fibulin 5
chr2_+_68872954 0.61 ENST00000394342.2
PROKR1
prokineticin receptor 1
chr8_-_93029865 0.56 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_92413727 0.46 ENST00000267620.10
FBLN5
fibulin 5
chr12_-_25101920 0.37 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr14_+_102276192 0.36 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr5_-_66492562 0.35 ENST00000256447.4
CD180
CD180 molecule
chr4_-_99578789 0.31 ENST00000511651.1
ENST00000505184.1
TSPAN5
tetraspanin 5
chr2_-_63815628 0.30 ENST00000409562.3
WDPCP
WD repeat containing planar cell polarity effector
chr7_-_138363824 0.28 ENST00000419765.3
SVOPL
SVOP-like
chr12_-_52867569 0.27 ENST00000252250.6
KRT6C
keratin 6C
chr12_-_25102252 0.27 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr22_+_31518938 0.26 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr9_-_124991124 0.26 ENST00000394319.4
ENST00000340587.3
LHX6
LIM homeobox 6
chr17_-_46691990 0.24 ENST00000576562.1
HOXB8
homeobox B8
chr10_+_103986085 0.23 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr17_+_56315787 0.23 ENST00000262290.4
ENST00000421678.2
LPO
lactoperoxidase
chr2_-_216300784 0.22 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr10_+_102756800 0.22 ENST00000370223.3
LZTS2
leucine zipper, putative tumor suppressor 2
chr10_-_17659357 0.22 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr1_+_150954493 0.22 ENST00000368947.4
ANXA9
annexin A9
chr17_+_56315936 0.21 ENST00000543544.1
LPO
lactoperoxidase
chr10_-_17659234 0.20 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr16_+_56965960 0.20 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_4336955 0.20 ENST00000355530.2
SPNS3
spinster homolog 3 (Drosophila)
chr5_-_178017355 0.20 ENST00000390654.3
COL23A1
collagen, type XXIII, alpha 1
chr17_+_4337199 0.20 ENST00000333476.2
SPNS3
spinster homolog 3 (Drosophila)
chr19_-_35992780 0.19 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN
dermokine
chr12_-_53074182 0.18 ENST00000252244.3
KRT1
keratin 1
chr14_-_74226961 0.18 ENST00000286523.5
ENST00000435371.1
ELMSAN1
ELM2 and Myb/SANT-like domain containing 1
chrX_-_133792480 0.16 ENST00000359237.4
PLAC1
placenta-specific 1
chr3_-_45883558 0.16 ENST00000445698.1
ENST00000296135.6
LZTFL1
leucine zipper transcription factor-like 1
chr8_-_93029520 0.16 ENST00000521553.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_43453734 0.16 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr12_-_63328817 0.15 ENST00000228705.6
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr1_-_20250110 0.15 ENST00000375116.3
PLA2G2E
phospholipase A2, group IIE
chr1_-_207143802 0.14 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr2_-_183106641 0.13 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr7_-_130598059 0.13 ENST00000432045.2
MIR29B1
microRNA 29a
chr1_+_33546714 0.13 ENST00000294517.6
ENST00000358680.3
ENST00000373443.3
ENST00000398167.1
ADC
arginine decarboxylase
chr16_+_56970567 0.13 ENST00000563911.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_30594823 0.13 ENST00000536287.1
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr7_-_44530479 0.13 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr5_+_118812294 0.13 ENST00000509514.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr3_+_15643476 0.13 ENST00000436193.1
ENST00000383778.4
BTD
biotinidase
chr4_+_157997209 0.12 ENST00000264428.4
GLRB
glycine receptor, beta
chr2_+_113825547 0.12 ENST00000341010.2
ENST00000337569.3
IL1F10
interleukin 1 family, member 10 (theta)
chr8_-_11058847 0.11 ENST00000297303.4
ENST00000416569.2
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr5_+_72143988 0.11 ENST00000506351.2
TNPO1
transportin 1
chr14_+_102276132 0.11 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr15_-_64126084 0.11 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr15_+_85923797 0.11 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr5_+_118812237 0.11 ENST00000513628.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr12_-_12491608 0.10 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr3_+_38017264 0.10 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr4_+_141178440 0.10 ENST00000394205.3
SCOC
short coiled-coil protein
chr11_-_8680383 0.10 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr9_+_110045537 0.10 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr8_-_18744528 0.09 ENST00000523619.1
PSD3
pleckstrin and Sec7 domain containing 3
chr6_-_31864977 0.09 ENST00000395728.3
ENST00000375528.4
EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr12_-_7899935 0.09 ENST00000543765.1
CLEC4C
C-type lectin domain family 4, member C
chr15_+_85923856 0.09 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13
A kinase (PRKA) anchor protein 13
chr12_-_7899958 0.09 ENST00000360345.3
CLEC4C
C-type lectin domain family 4, member C
chr7_-_99006443 0.08 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr11_+_61976137 0.08 ENST00000244930.4
SCGB2A1
secretoglobin, family 2A, member 1
chr21_-_46334186 0.08 ENST00000522931.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr3_+_186330712 0.08 ENST00000411641.2
ENST00000273784.5
AHSG
alpha-2-HS-glycoprotein
chr15_-_83837983 0.07 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr11_+_34073269 0.07 ENST00000389645.3
CAPRIN1
cell cycle associated protein 1
chr14_+_21387491 0.07 ENST00000258817.2
RP11-84C10.2
RP11-84C10.2
chr6_+_168399772 0.07 ENST00000443060.2
KIF25
kinesin family member 25
chr1_-_114447412 0.07 ENST00000369567.1
ENST00000369566.3
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr19_-_6604094 0.06 ENST00000597430.2
CD70
CD70 molecule
chr4_+_157997273 0.06 ENST00000541722.1
ENST00000512619.1
GLRB
glycine receptor, beta
chr1_-_114447683 0.06 ENST00000256658.4
ENST00000369564.1
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr14_+_62462541 0.06 ENST00000430451.2
SYT16
synaptotagmin XVI
chr13_-_45915221 0.06 ENST00000309246.5
ENST00000379060.4
ENST00000379055.1
ENST00000527226.1
ENST00000379056.1
TPT1
tumor protein, translationally-controlled 1
chr9_+_112542591 0.05 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr11_+_47279504 0.05 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr19_+_10736183 0.05 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2
solute carrier family 44 (choline transporter), member 2
chr10_-_13523073 0.05 ENST00000440282.1
BEND7
BEN domain containing 7
chr1_+_111770278 0.05 ENST00000369748.4
CHI3L2
chitinase 3-like 2
chr4_-_119274121 0.04 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr1_+_111770232 0.04 ENST00000369744.2
CHI3L2
chitinase 3-like 2
chr6_-_24489842 0.04 ENST00000230036.1
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr20_+_24929866 0.04 ENST00000480798.1
ENST00000376835.2
CST7
cystatin F (leukocystatin)
chrX_+_9431324 0.04 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr2_-_101925055 0.04 ENST00000295317.3
RNF149
ring finger protein 149
chr7_+_44040488 0.04 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr12_+_57857475 0.04 ENST00000528467.1
GLI1
GLI family zinc finger 1
chr16_-_70323422 0.04 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr1_-_67519782 0.03 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr11_+_62495997 0.03 ENST00000316461.4
TTC9C
tetratricopeptide repeat domain 9C
chr19_+_41497178 0.03 ENST00000324071.4
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr2_-_63815860 0.03 ENST00000272321.7
ENST00000431065.1
WDPCP
WD repeat containing planar cell polarity effector
chr16_-_18908196 0.03 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr20_-_31592113 0.03 ENST00000420875.1
ENST00000375519.2
ENST00000375523.3
ENST00000356173.3
SUN5
Sad1 and UNC84 domain containing 5
chr6_+_80341000 0.03 ENST00000369838.4
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr22_-_30901637 0.02 ENST00000381982.3
ENST00000255858.7
ENST00000540456.1
ENST00000392772.2
SEC14L4
SEC14-like 4 (S. cerevisiae)
chr4_+_111397216 0.02 ENST00000265162.5
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr11_-_10315741 0.02 ENST00000256190.8
SBF2
SET binding factor 2
chr2_-_159313214 0.01 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148
coiled-coil domain containing 148
chr11_+_62495541 0.01 ENST00000530625.1
ENST00000513247.2
TTC9C
tetratricopeptide repeat domain 9C
chr6_-_157744531 0.01 ENST00000400788.4
ENST00000367144.4
TMEM242
transmembrane protein 242
chr9_-_77502636 0.01 ENST00000449912.2
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr8_+_24151620 0.01 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr11_+_34073195 0.01 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr10_-_92681033 0.01 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chrX_-_138724677 0.00 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr10_+_86004802 0.00 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
RGR
retinal G protein coupled receptor
chr5_+_112074029 0.00 ENST00000512211.2
APC
adenomatous polyposis coli
chr17_-_34257731 0.00 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
RDM1
RAD52 motif 1
chr17_-_34257771 0.00 ENST00000394529.3
ENST00000293273.6
RDM1
RAD52 motif 1
chr2_+_192141611 0.00 ENST00000392316.1
MYO1B
myosin IB

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 1.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.2 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 0.3 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 0.3 GO:0016476 regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521)
0.1 0.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.2 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.2 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.8 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.3 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.2 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.7 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.0 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0071953 elastic fiber(GO:0071953)
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0044447 axoneme part(GO:0044447)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.6 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.1 0.4 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.2 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.3 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.7 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs