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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for DMC1

Z-value: 0.34

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_389662910.145.0e-01Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_76944621 2.03 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr17_+_77019030 0.61 ENST00000580454.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_+_77018896 0.60 ENST00000578229.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr7_+_142919130 0.59 ENST00000408947.3
TAS2R40
taste receptor, type 2, member 40
chr22_+_21133469 0.44 ENST00000406799.1
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chrX_-_63450480 0.39 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr17_+_31318886 0.35 ENST00000269053.3
ENST00000394638.1
SPACA3
sperm acrosome associated 3
chr3_-_108672742 0.34 ENST00000261047.3
GUCA1C
guanylate cyclase activator 1C
chr3_-_108672609 0.33 ENST00000393963.3
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr14_+_21525981 0.31 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr2_-_190044480 0.31 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr3_+_101546827 0.25 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr5_-_36301984 0.24 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L
RAN binding protein 3-like
chr2_+_233497931 0.24 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr10_-_74856608 0.23 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr11_-_85780086 0.22 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr11_-_85779971 0.21 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_+_26383318 0.20 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr21_-_46348694 0.19 ENST00000355153.4
ENST00000397850.2
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_-_62996066 0.19 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr2_+_187454749 0.19 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr6_+_26383404 0.17 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr3_+_148457585 0.17 ENST00000402260.1
AGTR1
angiotensin II receptor, type 1
chr18_-_5396271 0.17 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr21_-_46348626 0.17 ENST00000517563.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr15_-_42448788 0.16 ENST00000382396.4
ENST00000397272.3
PLA2G4F
phospholipase A2, group IVF
chr10_-_62332357 0.16 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_94727048 0.15 ENST00000283357.5
FAM81B
family with sequence similarity 81, member B
chr1_-_9714644 0.15 ENST00000377320.3
C1orf200
chromosome 1 open reading frame 200
chr1_+_18958008 0.14 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr10_+_69865866 0.14 ENST00000354393.2
MYPN
myopalladin
chr10_-_104597286 0.14 ENST00000369887.3
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr17_+_74075263 0.13 ENST00000334586.5
ENST00000392503.2
ZACN
zinc activated ligand-gated ion channel
chr7_-_22539771 0.12 ENST00000406890.2
ENST00000424363.1
STEAP1B
STEAP family member 1B
chr18_+_56892724 0.12 ENST00000456142.3
ENST00000530323.1
GRP
gastrin-releasing peptide
chr2_-_75426826 0.12 ENST00000305249.5
TACR1
tachykinin receptor 1
chr11_+_71238313 0.11 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr6_-_31670723 0.11 ENST00000440843.2
ENST00000375842.4
ABHD16A
abhydrolase domain containing 16A
chr2_-_85641162 0.10 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG
capping protein (actin filament), gelsolin-like
chr19_+_11466062 0.09 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr7_+_150758304 0.09 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr11_-_73720276 0.08 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr7_+_6793740 0.07 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr14_-_47351391 0.07 ENST00000399222.3
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr7_-_150884332 0.06 ENST00000275838.1
ENST00000422024.1
ENST00000434669.1
ASB10
ankyrin repeat and SOCS box containing 10
chr7_-_6010263 0.06 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr6_+_116782527 0.06 ENST00000368606.3
ENST00000368605.1
FAM26F
family with sequence similarity 26, member F
chr6_+_46661575 0.06 ENST00000450697.1
TDRD6
tudor domain containing 6
chr8_+_145438870 0.06 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr16_+_2255710 0.05 ENST00000397124.1
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr2_+_219247021 0.05 ENST00000539932.1
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr6_+_88054530 0.05 ENST00000388923.4
C6orf163
chromosome 6 open reading frame 163
chr10_+_11047259 0.05 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr17_-_60142609 0.05 ENST00000397786.2
MED13
mediator complex subunit 13
chr2_-_18741882 0.04 ENST00000381249.3
RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr17_+_38333263 0.04 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr19_-_42947121 0.04 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr2_-_163008903 0.04 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr12_-_109025849 0.04 ENST00000228463.6
SELPLG
selectin P ligand
chr11_-_73720122 0.04 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chrX_-_134305322 0.04 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr11_+_71846764 0.03 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr1_+_166958497 0.03 ENST00000367870.2
MAEL
maelstrom spermatogenic transposon silencer
chr1_+_166958346 0.03 ENST00000367872.4
MAEL
maelstrom spermatogenic transposon silencer
chr1_-_182642017 0.02 ENST00000367557.4
ENST00000258302.4
RGS8
regulator of G-protein signaling 8
chr15_-_49103235 0.02 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr10_-_98031265 0.02 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr14_-_21492113 0.02 ENST00000554094.1
NDRG2
NDRG family member 2
chr7_-_150884873 0.02 ENST00000377867.3
ASB10
ankyrin repeat and SOCS box containing 10
chr11_+_71846748 0.02 ENST00000445078.2
FOLR3
folate receptor 3 (gamma)
chr10_-_98031310 0.01 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr20_+_11008408 0.01 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr14_-_21492251 0.01 ENST00000554398.1
NDRG2
NDRG family member 2
chr10_-_135187193 0.00 ENST00000368547.3
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr1_-_190446759 0.00 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr20_+_123010 0.00 ENST00000382398.3
DEFB126
defensin, beta 126

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 1.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.4 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.7 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.4 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:0035106 angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.1 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.4 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.7 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.2 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.4 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines