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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for DUXA

Z-value: 0.80

Motif logo

Transcription factors associated with DUXA

Gene Symbol Gene ID Gene Info
ENSG00000258873.2 double homeobox A

Activity profile of DUXA motif

Sorted Z-values of DUXA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_228678550 4.75 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr21_+_43619796 2.17 ENST00000398457.2
ATP-binding cassette, sub-family G (WHITE), member 1
chr2_+_161993465 1.98 ENST00000457476.1
TRAF family member-associated NFKB activator
chr12_-_49259643 1.88 ENST00000309739.5
Rho family GTPase 1
chr1_+_12916941 1.78 ENST00000240189.2
PRAME family member 2
chr2_-_225811747 1.73 ENST00000409592.3
dedicator of cytokinesis 10
chr8_+_86747543 1.70 ENST00000425429.2
REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 11, pseudogene
chr2_+_201994042 1.30 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chr2_+_161993412 1.25 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr18_+_61554932 1.23 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr2_-_231989808 1.23 ENST00000258400.3
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr11_+_49050504 1.13 ENST00000332682.7
tripartite motif containing 49B
chr12_-_10959892 1.04 ENST00000240615.2
taste receptor, type 2, member 8
chr5_+_125758865 1.02 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr15_-_80263506 1.01 ENST00000335661.6
BCL2-related protein A1
chr5_+_125758813 1.01 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr2_+_201994208 0.99 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr15_+_71228826 0.96 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
leucine rich repeat containing 49
chr1_-_13005246 0.93 ENST00000415464.2
PRAME family member 6
chr1_+_12851545 0.89 ENST00000332296.7
PRAME family member 1
chr1_+_13516066 0.89 ENST00000332192.6
PRAME family member 21
chr22_+_41697520 0.89 ENST00000352645.4
zinc finger CCCH-type containing 7B
chr14_+_22615942 0.80 ENST00000390457.2
T cell receptor alpha variable 27
chr18_+_61445007 0.79 ENST00000447428.1
ENST00000546027.1
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr10_-_49860525 0.77 ENST00000435790.2
Rho GTPase activating protein 22
chr1_+_12976450 0.77 ENST00000361079.2
PRAME family member 7
chr2_+_201994569 0.73 ENST00000457277.1
CASP8 and FADD-like apoptosis regulator
chr3_-_194188956 0.72 ENST00000256031.4
ENST00000446356.1
ATPase type 13A3
chr5_-_16742330 0.72 ENST00000505695.1
ENST00000427430.2
myosin X
chr17_+_56232494 0.70 ENST00000268912.5
olfactory receptor, family 4, subfamily D, member 1
chr16_+_57220193 0.70 ENST00000564435.1
ENST00000562959.1
ENST00000394420.4
ENST00000568505.2
ENST00000537866.1
ring finger and SPRY domain containing 1
chr3_-_195997410 0.70 ENST00000419333.1
phosphate cytidylyltransferase 1, choline, alpha
chr2_+_111880242 0.69 ENST00000393252.3
BCL2-like 11 (apoptosis facilitator)
chr12_-_91546926 0.69 ENST00000550758.1
decorin
chr5_-_95297534 0.66 ENST00000513343.1
ENST00000431061.2
elongation factor, RNA polymerase II, 2
chr6_+_150920999 0.65 ENST00000367328.1
ENST00000367326.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_-_13390765 0.64 ENST00000357367.2
PRAME family member 8
chr12_-_51422017 0.64 ENST00000394904.3
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr3_+_190333097 0.61 ENST00000412080.1
interleukin 1 receptor accessory protein
chr17_-_39296739 0.60 ENST00000345847.4
keratin associated protein 4-6
chr15_+_66679155 0.54 ENST00000307102.5
mitogen-activated protein kinase kinase 1
chr3_+_159943362 0.53 ENST00000326474.3
chromosome 3 open reading frame 80
chr1_-_13115578 0.53 ENST00000414205.2
PRAME family member 6
chr1_+_170501270 0.52 ENST00000367763.3
ENST00000367762.1
golgin, RAB6-interacting
chr5_-_95297678 0.52 ENST00000237853.4
elongation factor, RNA polymerase II, 2
chrX_+_18725758 0.51 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
protein phosphatase, EF-hand calcium binding domain 1
chr17_+_57408994 0.50 ENST00000312655.4
yippee-like 2 (Drosophila)
chr1_+_50569575 0.50 ENST00000371827.1
ELAV like neuron-specific RNA binding protein 4
chr6_+_135502466 0.49 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr6_+_12717892 0.49 ENST00000379350.1
phosphatase and actin regulator 1
chr3_-_164914640 0.48 ENST00000241274.3
SLIT and NTRK-like family, member 3
chr7_-_45151272 0.48 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
transforming growth factor beta regulator 4
chr5_+_54320078 0.48 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr2_-_175629135 0.46 ENST00000409542.1
ENST00000409219.1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr2_-_175629164 0.43 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr6_+_26402465 0.43 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
butyrophilin, subfamily 3, member A1
chr17_-_79849438 0.43 ENST00000331204.4
ENST00000505490.2
Aly/REF export factor
chr1_-_12908578 0.43 ENST00000317869.6
heterogeneous nuclear ribonucleoprotein C-like 1
chr19_+_7030589 0.42 ENST00000329753.5
methyl-CpG binding domain protein 3-like 5
chr4_-_69536346 0.41 ENST00000338206.5
UDP glucuronosyltransferase 2 family, polypeptide B15
chr6_-_134639180 0.41 ENST00000367858.5
serum/glucocorticoid regulated kinase 1
chr19_+_7049332 0.41 ENST00000381393.3
methyl-CpG binding domain protein 3-like 2
chr6_+_31553978 0.40 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr7_+_134331550 0.40 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
2,3-bisphosphoglycerate mutase
chr19_-_7040190 0.39 ENST00000381394.4
methyl-CpG binding domain protein 3-like 4
chr19_-_14785674 0.39 ENST00000253673.5
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_-_10587897 0.38 ENST00000405333.1
ENST00000443218.1
ornithine decarboxylase 1
chr6_+_50061315 0.38 ENST00000415106.1
RP11-397G17.1
chr11_-_18610246 0.38 ENST00000379387.4
ENST00000541984.1
UEV and lactate/malate dehyrogenase domains
chr11_+_43333513 0.38 ENST00000534695.1
ENST00000455725.2
ENST00000531273.1
ENST00000420461.2
ENST00000378852.3
ENST00000534600.1
apoptosis inhibitor 5
chr19_-_14785622 0.38 ENST00000443157.2
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_-_89160117 0.38 ENST00000390238.2
immunoglobulin kappa joining 5
chr1_-_220219775 0.38 ENST00000609181.1
glutamyl-prolyl-tRNA synthetase
chr12_+_26126681 0.38 ENST00000542865.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr19_-_12833361 0.38 ENST00000592287.1
transportin 2
chr8_-_125577940 0.38 ENST00000519168.1
ENST00000395508.2
metastasis suppressor 1
chr15_+_44719970 0.37 ENST00000558966.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr12_-_114211474 0.37 ENST00000550905.1
ENST00000547963.1
RP11-438N16.1
chr1_+_13359819 0.37 ENST00000376168.1
PRAME family member 5
chr2_-_161350305 0.37 ENST00000348849.3
RNA binding motif, single stranded interacting protein 1
chr19_-_14785698 0.37 ENST00000344373.4
ENST00000595472.1
egf-like module containing, mucin-like, hormone receptor-like 3
chr5_+_172571445 0.37 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BCL2/adenovirus E1B 19kDa interacting protein 1
chr5_+_142149932 0.36 ENST00000274498.4
Rho GTPase activating protein 26
chr6_+_55039050 0.35 ENST00000370862.3
hypocretin (orexin) receptor 2
chr6_+_31553901 0.35 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr17_+_66511540 0.34 ENST00000588188.2
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr6_-_9939552 0.33 ENST00000460363.2
orofacial cleft 1 candidate 1
chr17_+_66521936 0.33 ENST00000592800.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr4_+_169552748 0.33 ENST00000504519.1
ENST00000512127.1
palladin, cytoskeletal associated protein
chr1_-_13007420 0.32 ENST00000376189.1
PRAME family member 6
chr7_-_137686791 0.32 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
cAMP responsive element binding protein 3-like 2
chr1_-_165414414 0.32 ENST00000359842.5
retinoid X receptor, gamma
chr19_-_54663473 0.32 ENST00000222224.3
leukocyte receptor cluster (LRC) member 1
chr1_+_78956651 0.32 ENST00000370757.3
ENST00000370756.3
prostaglandin F receptor (FP)
chr8_-_86575726 0.32 ENST00000379010.2
REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene
chr18_-_74839891 0.31 ENST00000581878.1
myelin basic protein
chr10_+_90424196 0.31 ENST00000394375.3
ENST00000608620.1
ENST00000238983.4
ENST00000355843.2
lipase, gastric
chr12_+_111284764 0.31 ENST00000545036.1
ENST00000308208.5
coiled-coil domain containing 63
chr10_+_82297658 0.31 ENST00000339284.2
SH2 domain containing 4B
chr19_-_7058651 0.31 ENST00000333843.4
methyl-CpG binding domain protein 3-like 3
chr2_+_169923577 0.30 ENST00000432060.2
dehydrogenase/reductase (SDR family) member 9
chr1_-_168464875 0.30 ENST00000422253.1
RP5-968D22.3
chr8_+_82192501 0.30 ENST00000297258.6
fatty acid binding protein 5 (psoriasis-associated)
chr22_+_45725524 0.29 ENST00000405548.3
family with sequence similarity 118, member A
chr4_+_76649797 0.29 ENST00000538159.1
ENST00000514213.2
USO1 vesicle transport factor
chr3_-_120461353 0.29 ENST00000483733.1
RAB, member of RAS oncogene family-like 3
chr5_-_115872142 0.29 ENST00000510263.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr6_+_26199737 0.28 ENST00000359985.1
histone cluster 1, H2bf
chr11_-_89653576 0.28 ENST00000420869.1
tripartite motif containing 49D1
chr17_-_74733404 0.27 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
serine/arginine-rich splicing factor 2
chr2_+_101437487 0.27 ENST00000427413.1
ENST00000542504.1
neuronal PAS domain protein 2
chr4_-_111563076 0.27 ENST00000354925.2
ENST00000511990.1
paired-like homeodomain 2
chr1_-_12946025 0.27 ENST00000235349.5
PRAME family member 4
chr8_-_7673238 0.27 ENST00000335021.2
defensin, beta 107A
chr15_-_66679019 0.27 ENST00000568216.1
ENST00000562124.1
ENST00000570251.1
TIMELESS interacting protein
chr12_+_8662057 0.26 ENST00000382064.2
C-type lectin domain family 4, member D
chr18_+_44812072 0.26 ENST00000598649.1
ENST00000586905.2
CTD-2130O13.1
chr2_-_202563414 0.26 ENST00000409474.3
ENST00000315506.7
ENST00000359962.5
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_-_13517565 0.25 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr3_-_112564797 0.25 ENST00000398214.1
ENST00000448932.1
CD200 receptor 1-like
chr1_-_42801540 0.25 ENST00000372573.1
forkhead box J3
chr11_+_60102304 0.24 ENST00000300182.4
membrane-spanning 4-domains, subfamily A, member 6E
chr1_-_220220000 0.24 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr12_+_111284805 0.24 ENST00000552694.1
coiled-coil domain containing 63
chr1_+_78769549 0.23 ENST00000370758.1
prostaglandin F receptor (FP)
chr8_+_7353368 0.23 ENST00000355602.2
defensin, beta 107B
chrX_+_85969626 0.23 ENST00000484479.1
dachshund homolog 2 (Drosophila)
chr4_-_70080449 0.23 ENST00000446444.1
UDP glucuronosyltransferase 2 family, polypeptide B11
chr13_+_109248500 0.23 ENST00000356711.2
myosin XVI
chr9_-_99417562 0.23 ENST00000375234.3
ENST00000446045.1
AhpC/TSA antioxidant enzyme domain containing 1
chr6_-_49604545 0.23 ENST00000371175.4
ENST00000229810.7
Rh-associated glycoprotein
chr5_+_173472607 0.23 ENST00000303177.3
ENST00000519867.1
Neuron-specific protein family member 2
chr10_-_112064665 0.22 ENST00000369603.5
survival motor neuron domain containing 1
chr3_+_126911974 0.22 ENST00000398112.1
chromosome 3 open reading frame 56
chr8_-_6420930 0.22 ENST00000325203.5
angiopoietin 2
chr5_+_142149955 0.22 ENST00000378004.3
Rho GTPase activating protein 26
chr6_+_26402517 0.22 ENST00000414912.2
butyrophilin, subfamily 3, member A1
chr19_-_12833164 0.21 ENST00000356861.5
transportin 2
chr1_+_13421176 0.21 ENST00000376152.1
PRAME family member 9
chr3_-_196242233 0.21 ENST00000397537.2
single-pass membrane protein with coiled-coil domains 1
chr3_-_120461378 0.21 ENST00000273375.3
RAB, member of RAS oncogene family-like 3
chr1_-_153283194 0.21 ENST00000290722.1
peptidoglycan recognition protein 3
chrY_-_13524717 0.21 ENST00000331172.6
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 pseudogene 1
chr8_-_29605625 0.21 ENST00000506121.3
long intergenic non-protein coding RNA 589
chr14_-_80697396 0.20 ENST00000557010.1
deiodinase, iodothyronine, type II
chr15_+_98503922 0.20 ENST00000268042.6
arrestin domain containing 4
chr17_-_73401567 0.20 ENST00000392562.1
growth factor receptor-bound protein 2
chrX_+_15525426 0.20 ENST00000342014.6
BMX non-receptor tyrosine kinase
chr16_+_21716284 0.20 ENST00000388957.3
otoancorin
chr17_+_40925454 0.19 ENST00000253794.2
ENST00000590339.1
ENST00000589520.1
vacuolar protein sorting 25 homolog (S. cerevisiae)
chr4_-_119759795 0.19 ENST00000419654.2
SEC24 family member D
chr3_-_155572164 0.18 ENST00000392845.3
ENST00000359479.3
solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_-_11374904 0.18 ENST00000528848.2
casein kinase 2, alpha 3 polypeptide
chr19_-_6393216 0.18 ENST00000595047.1
general transcription factor IIF, polypeptide 1, 74kDa
chr1_-_13452656 0.18 ENST00000376132.3
PRAME family member 13
chr5_+_140723601 0.18 ENST00000253812.6
protocadherin gamma subfamily A, 3
chr1_-_13117736 0.18 ENST00000376192.5
ENST00000376182.1
PRAME family member 6
chr6_-_133055896 0.18 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
vanin 3
chr2_+_169923504 0.17 ENST00000357546.2
dehydrogenase/reductase (SDR family) member 9
chr6_-_89927151 0.17 ENST00000454853.2
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_-_74663825 0.17 ENST00000370911.3
ENST00000370909.2
ENST00000354431.4
leucine-rich repeats and IQ motif containing 3
chrX_-_68385274 0.17 ENST00000374584.3
ENST00000590146.1
praja ring finger 1, E3 ubiquitin protein ligase
chr6_+_35996859 0.17 ENST00000472333.1
mitogen-activated protein kinase 14
chr4_-_100575781 0.17 ENST00000511828.1
Protein LOC285556
chr6_-_26199499 0.17 ENST00000377831.5
histone cluster 1, H3d
chr11_+_55650773 0.16 ENST00000449290.2
tripartite motif-containing 51
chr2_-_86333244 0.16 ENST00000263857.6
ENST00000409681.1
polymerase (RNA) I polypeptide A, 194kDa
chr17_+_7476136 0.16 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
eukaryotic translation initiation factor 4A1
chr5_+_98109322 0.16 ENST00000513185.1
repulsive guidance molecule family member b
chr5_+_101569696 0.16 ENST00000597120.1
AC008948.1
chr6_+_26251835 0.16 ENST00000356350.2
histone cluster 1, H2bh
chr4_-_46126093 0.16 ENST00000295452.4
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr7_+_93535866 0.16 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr12_-_114211444 0.16 ENST00000510694.2
ENST00000550223.1
RP11-438N16.1
chr1_-_157811588 0.16 ENST00000368174.4
CD5 molecule-like
chr4_+_146539415 0.16 ENST00000281317.5
methylmalonic aciduria (cobalamin deficiency) cblA type
chr11_+_30253410 0.16 ENST00000533718.1
follicle stimulating hormone, beta polypeptide
chr1_-_117210290 0.15 ENST00000369483.1
ENST00000369486.3
immunoglobulin superfamily, member 3
chr6_-_66417107 0.15 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
eyes shut homolog (Drosophila)
chr6_+_167704798 0.15 ENST00000230256.3
unc-93 homolog A (C. elegans)
chr10_-_29811456 0.15 ENST00000535393.1
supervillin
chrX_-_72095808 0.15 ENST00000373529.5
DMRT-like family C1
chr6_+_167704838 0.15 ENST00000366829.2
unc-93 homolog A (C. elegans)
chr11_-_85376121 0.15 ENST00000527447.1
CREB/ATF bZIP transcription factor
chr14_-_30766223 0.15 ENST00000549360.1
ENST00000508469.2
CTD-2251F13.1
chr17_-_2996290 0.14 ENST00000331459.1
olfactory receptor, family 1, subfamily D, member 2
chr3_-_128186091 0.14 ENST00000319153.3
DnaJ (Hsp40) homolog, subfamily B, member 8
chr2_+_54342533 0.14 ENST00000406041.1
acylphosphatase 2, muscle type
chrX_+_11311533 0.14 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
amelogenin, X-linked
chr14_+_20937538 0.14 ENST00000361505.5
ENST00000553591.1
purine nucleoside phosphorylase
chr1_+_13641973 0.14 ENST00000330087.5
PRAME family member 15
chrX_-_48980098 0.14 ENST00000156109.5
G patch domain and KOW motifs
chr1_-_13673511 0.13 ENST00000344998.3
ENST00000334600.6
PRAME family member 14
chr2_-_105030466 0.13 ENST00000449772.1
AC068535.3
chr7_+_93535817 0.13 ENST00000248572.5
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr6_-_26199471 0.13 ENST00000341023.1
histone cluster 1, H2ad
chr1_+_158323634 0.13 ENST00000452291.2
ENST00000368165.3
ENST00000368166.3
ENST00000368163.3
ENST00000368164.3
CD1e molecule
chr19_-_3061397 0.13 ENST00000586839.1
amino-terminal enhancer of split
chr11_+_13690249 0.13 ENST00000532701.1
fatty acyl CoA reductase 1
chr1_+_117963209 0.13 ENST00000449370.2
mannosidase, alpha, class 1A, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of DUXA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.5 2.2 GO:0055099 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
0.5 3.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 3.0 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2 1.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 0.7 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.2 0.6 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.2 0.8 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.2 0.5 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.6 GO:0015692 lead ion transport(GO:0015692)
0.1 1.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 1.9 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.9 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.6 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.3 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.1 0.5 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.1 0.3 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.2 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.2 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.1 0.4 GO:0030035 microspike assembly(GO:0030035)
0.1 0.6 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 1.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 0.4 GO:0042746 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.1 0.2 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.3 GO:1904209 maintenance of blood-brain barrier(GO:0035633) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0006738 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.0 0.1 GO:1904397 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.5 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.4 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.7 GO:2000480 negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.3 GO:0048478 replication fork protection(GO:0048478)
0.0 1.2 GO:0042730 fibrinolysis(GO:0042730)
0.0 1.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.5 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.1 GO:1901420 negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.4 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.2 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.0 0.6 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.2 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.3 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.0 GO:0033121 regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0055096 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.3 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0043335 protein unfolding(GO:0043335)
0.0 1.2 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 0.6 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.6 GO:0097452 GAIT complex(GO:0097452)
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.1 0.2 GO:0000814 ESCRT II complex(GO:0000814)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.7 2.2 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.5 3.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 0.6 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.2 0.6 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.6 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.6 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.1 0.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 3.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.4 GO:0016499 orexin receptor activity(GO:0016499)
0.1 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 1.0 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0017129 triglyceride binding(GO:0017129)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.3 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.4 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.0 GO:0016160 amylase activity(GO:0016160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.4 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 2.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 3.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 4.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.6 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 3.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling