Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for DUXA
Z-value: 0.80
Motif logo
Transcription factors associated with DUXA
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_228678550 Show fit | 4.75 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr21_+_43619796 Show fit | 2.17 |
ENST00000398457.2
|
ATP-binding cassette, sub-family G (WHITE), member 1 |
|
| chr2_+_161993465 Show fit | 1.98 |
ENST00000457476.1
|
TRAF family member-associated NFKB activator |
|
| chr12_-_49259643 Show fit | 1.88 |
ENST00000309739.5
|
Rho family GTPase 1 |
|
| chr1_+_12916941 Show fit | 1.78 |
ENST00000240189.2
|
PRAME family member 2 |
|
| chr2_-_225811747 Show fit | 1.73 |
ENST00000409592.3
|
dedicator of cytokinesis 10 |
|
| chr8_+_86747543 Show fit | 1.70 |
ENST00000425429.2
|
REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 11, pseudogene |
|
| chr2_+_201994042 Show fit | 1.30 |
ENST00000417748.1
|
CASP8 and FADD-like apoptosis regulator |
|
| chr2_+_161993412 Show fit | 1.25 |
ENST00000259075.2
ENST00000432002.1 |
TRAF family member-associated NFKB activator |
|
| chr18_+_61554932 Show fit | 1.23 |
ENST00000299502.4
ENST00000457692.1 ENST00000413956.1 |
serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DUXA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.8 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.5 | 3.2 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.3 | 3.0 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.5 | 2.2 | GO:0055099 | detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099) |
| 0.1 | 1.9 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.1 | 1.7 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 1.5 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.2 | 1.2 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.0 | 1.2 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 1.2 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0097342 | CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342) |
| 0.0 | 1.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.9 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.7 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.7 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 0.7 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 0.7 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 0.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.6 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 0.6 | GO:0097452 | GAIT complex(GO:0097452) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.8 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.5 | 3.2 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 3.0 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.7 | 2.2 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.0 | 1.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.2 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.0 | 1.0 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.9 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 0.7 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.7 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 3.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 3.0 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 1.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.7 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 0.9 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |