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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for DUXA

Z-value: 0.80

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Transcription factors associated with DUXA

Gene Symbol Gene ID Gene Info
DUXA
ENSG00000258873.2 double homeobox A

Activity profile of DUXA motif

Sorted Z-values of DUXA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_228678550 4.75 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr21_+_43619796 2.17 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr2_+_161993465 1.98 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr12_-_49259643 1.88 ENST00000309739.5
RND1
Rho family GTPase 1
chr1_+_12916941 1.78 ENST00000240189.2
PRAMEF2
PRAME family member 2
chr2_-_225811747 1.73 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr8_+_86747543 1.70 ENST00000425429.2
REXO1L11P
REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 11, pseudogene
chr2_+_201994042 1.30 ENST00000417748.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_+_161993412 1.25 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr18_+_61554932 1.23 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
SERPINB2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr2_-_231989808 1.23 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr11_+_49050504 1.13 ENST00000332682.7
TRIM49B
tripartite motif containing 49B
chr12_-_10959892 1.04 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr5_+_125758865 1.02 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr15_-_80263506 1.01 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr5_+_125758813 1.01 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr2_+_201994208 0.99 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr15_+_71228826 0.96 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
LRRC49
leucine rich repeat containing 49
chr1_-_13005246 0.93 ENST00000415464.2
PRAMEF6
PRAME family member 6
chr1_+_12851545 0.89 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr1_+_13516066 0.89 ENST00000332192.6
PRAMEF21
PRAME family member 21
chr22_+_41697520 0.89 ENST00000352645.4
ZC3H7B
zinc finger CCCH-type containing 7B
chr14_+_22615942 0.80 ENST00000390457.2
TRAV27
T cell receptor alpha variable 27
chr18_+_61445007 0.79 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr10_-_49860525 0.77 ENST00000435790.2
ARHGAP22
Rho GTPase activating protein 22
chr1_+_12976450 0.77 ENST00000361079.2
PRAMEF7
PRAME family member 7
chr2_+_201994569 0.73 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_-_194188956 0.72 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr5_-_16742330 0.72 ENST00000505695.1
ENST00000427430.2
MYO10
myosin X
chr17_+_56232494 0.70 ENST00000268912.5
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr16_+_57220193 0.70 ENST00000564435.1
ENST00000562959.1
ENST00000394420.4
ENST00000568505.2
ENST00000537866.1
RSPRY1
ring finger and SPRY domain containing 1
chr3_-_195997410 0.70 ENST00000419333.1
PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr2_+_111880242 0.69 ENST00000393252.3
BCL2L11
BCL2-like 11 (apoptosis facilitator)
chr12_-_91546926 0.69 ENST00000550758.1
DCN
decorin
chr5_-_95297534 0.66 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr6_+_150920999 0.65 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_-_13390765 0.64 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr12_-_51422017 0.64 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr3_+_190333097 0.61 ENST00000412080.1
IL1RAP
interleukin 1 receptor accessory protein
chr17_-_39296739 0.60 ENST00000345847.4
KRTAP4-6
keratin associated protein 4-6
chr15_+_66679155 0.54 ENST00000307102.5
MAP2K1
mitogen-activated protein kinase kinase 1
chr3_+_159943362 0.53 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr1_-_13115578 0.53 ENST00000414205.2
PRAMEF6
PRAME family member 6
chr1_+_170501270 0.52 ENST00000367763.3
ENST00000367762.1
GORAB
golgin, RAB6-interacting
chr5_-_95297678 0.52 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chrX_+_18725758 0.51 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chr17_+_57408994 0.50 ENST00000312655.4
YPEL2
yippee-like 2 (Drosophila)
chr1_+_50569575 0.50 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr6_+_135502466 0.49 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr6_+_12717892 0.49 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr3_-_164914640 0.48 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr7_-_45151272 0.48 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
TBRG4
transforming growth factor beta regulator 4
chr5_+_54320078 0.48 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr2_-_175629135 0.46 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr2_-_175629164 0.43 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr6_+_26402465 0.43 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr17_-_79849438 0.43 ENST00000331204.4
ENST00000505490.2
ALYREF
Aly/REF export factor
chr1_-_12908578 0.43 ENST00000317869.6
HNRNPCL1
heterogeneous nuclear ribonucleoprotein C-like 1
chr19_+_7030589 0.42 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr4_-_69536346 0.41 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr6_-_134639180 0.41 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr19_+_7049332 0.41 ENST00000381393.3
MBD3L2
methyl-CpG binding domain protein 3-like 2
chr6_+_31553978 0.40 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr7_+_134331550 0.40 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
BPGM
2,3-bisphosphoglycerate mutase
chr19_-_7040190 0.39 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr19_-_14785674 0.39 ENST00000253673.5
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_-_10587897 0.38 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr6_+_50061315 0.38 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr11_-_18610246 0.38 ENST00000379387.4
ENST00000541984.1
UEVLD
UEV and lactate/malate dehyrogenase domains
chr11_+_43333513 0.38 ENST00000534695.1
ENST00000455725.2
ENST00000531273.1
ENST00000420461.2
ENST00000378852.3
ENST00000534600.1
API5
apoptosis inhibitor 5
chr19_-_14785622 0.38 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_-_89160117 0.38 ENST00000390238.2
IGKJ5
immunoglobulin kappa joining 5
chr1_-_220219775 0.38 ENST00000609181.1
EPRS
glutamyl-prolyl-tRNA synthetase
chr12_+_26126681 0.38 ENST00000542865.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr19_-_12833361 0.38 ENST00000592287.1
TNPO2
transportin 2
chr8_-_125577940 0.38 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr15_+_44719970 0.37 ENST00000558966.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr12_-_114211474 0.37 ENST00000550905.1
ENST00000547963.1
RP11-438N16.1
RP11-438N16.1
chr1_+_13359819 0.37 ENST00000376168.1
PRAMEF5
PRAME family member 5
chr2_-_161350305 0.37 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr19_-_14785698 0.37 ENST00000344373.4
ENST00000595472.1
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr5_+_172571445 0.37 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BNIP1
BCL2/adenovirus E1B 19kDa interacting protein 1
chr5_+_142149932 0.36 ENST00000274498.4
ARHGAP26
Rho GTPase activating protein 26
chr6_+_55039050 0.35 ENST00000370862.3
HCRTR2
hypocretin (orexin) receptor 2
chr6_+_31553901 0.35 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr17_+_66511540 0.34 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr6_-_9939552 0.33 ENST00000460363.2
OFCC1
orofacial cleft 1 candidate 1
chr17_+_66521936 0.33 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr4_+_169552748 0.33 ENST00000504519.1
ENST00000512127.1
PALLD
palladin, cytoskeletal associated protein
chr1_-_13007420 0.32 ENST00000376189.1
PRAMEF6
PRAME family member 6
chr7_-_137686791 0.32 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chr1_-_165414414 0.32 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr19_-_54663473 0.32 ENST00000222224.3
LENG1
leukocyte receptor cluster (LRC) member 1
chr1_+_78956651 0.32 ENST00000370757.3
ENST00000370756.3
PTGFR
prostaglandin F receptor (FP)
chr8_-_86575726 0.32 ENST00000379010.2
REXO1L1
REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene
chr18_-_74839891 0.31 ENST00000581878.1
MBP
myelin basic protein
chr10_+_90424196 0.31 ENST00000394375.3
ENST00000608620.1
ENST00000238983.4
ENST00000355843.2
LIPF
lipase, gastric
chr12_+_111284764 0.31 ENST00000545036.1
ENST00000308208.5
CCDC63
coiled-coil domain containing 63
chr10_+_82297658 0.31 ENST00000339284.2
SH2D4B
SH2 domain containing 4B
chr19_-_7058651 0.31 ENST00000333843.4
MBD3L3
methyl-CpG binding domain protein 3-like 3
chr2_+_169923577 0.30 ENST00000432060.2
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_168464875 0.30 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr8_+_82192501 0.30 ENST00000297258.6
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr22_+_45725524 0.29 ENST00000405548.3
FAM118A
family with sequence similarity 118, member A
chr4_+_76649797 0.29 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr3_-_120461353 0.29 ENST00000483733.1
RABL3
RAB, member of RAS oncogene family-like 3
chr5_-_115872142 0.29 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr6_+_26199737 0.28 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr11_-_89653576 0.28 ENST00000420869.1
TRIM49D1
tripartite motif containing 49D1
chr17_-_74733404 0.27 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr2_+_101437487 0.27 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr4_-_111563076 0.27 ENST00000354925.2
ENST00000511990.1
PITX2
paired-like homeodomain 2
chr1_-_12946025 0.27 ENST00000235349.5
PRAMEF4
PRAME family member 4
chr8_-_7673238 0.27 ENST00000335021.2
DEFB107A
defensin, beta 107A
chr15_-_66679019 0.27 ENST00000568216.1
ENST00000562124.1
ENST00000570251.1
TIPIN
TIMELESS interacting protein
chr12_+_8662057 0.26 ENST00000382064.2
CLEC4D
C-type lectin domain family 4, member D
chr18_+_44812072 0.26 ENST00000598649.1
ENST00000586905.2
CTD-2130O13.1
CTD-2130O13.1
chr2_-_202563414 0.26 ENST00000409474.3
ENST00000315506.7
ENST00000359962.5
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_-_13517565 0.25 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr3_-_112564797 0.25 ENST00000398214.1
ENST00000448932.1
CD200R1L
CD200 receptor 1-like
chr1_-_42801540 0.25 ENST00000372573.1
FOXJ3
forkhead box J3
chr11_+_60102304 0.24 ENST00000300182.4
MS4A6E
membrane-spanning 4-domains, subfamily A, member 6E
chr1_-_220220000 0.24 ENST00000366923.3
EPRS
glutamyl-prolyl-tRNA synthetase
chr12_+_111284805 0.24 ENST00000552694.1
CCDC63
coiled-coil domain containing 63
chr1_+_78769549 0.23 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr8_+_7353368 0.23 ENST00000355602.2
DEFB107B
defensin, beta 107B
chrX_+_85969626 0.23 ENST00000484479.1
DACH2
dachshund homolog 2 (Drosophila)
chr4_-_70080449 0.23 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr13_+_109248500 0.23 ENST00000356711.2
MYO16
myosin XVI
chr9_-_99417562 0.23 ENST00000375234.3
ENST00000446045.1
AAED1
AhpC/TSA antioxidant enzyme domain containing 1
chr6_-_49604545 0.23 ENST00000371175.4
ENST00000229810.7
RHAG
Rh-associated glycoprotein
chr5_+_173472607 0.23 ENST00000303177.3
ENST00000519867.1
NSG2
Neuron-specific protein family member 2
chr10_-_112064665 0.22 ENST00000369603.5
SMNDC1
survival motor neuron domain containing 1
chr3_+_126911974 0.22 ENST00000398112.1
C3orf56
chromosome 3 open reading frame 56
chr8_-_6420930 0.22 ENST00000325203.5
ANGPT2
angiopoietin 2
chr5_+_142149955 0.22 ENST00000378004.3
ARHGAP26
Rho GTPase activating protein 26
chr6_+_26402517 0.22 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr19_-_12833164 0.21 ENST00000356861.5
TNPO2
transportin 2
chr1_+_13421176 0.21 ENST00000376152.1
PRAMEF9
PRAME family member 9
chr3_-_196242233 0.21 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr3_-_120461378 0.21 ENST00000273375.3
RABL3
RAB, member of RAS oncogene family-like 3
chr1_-_153283194 0.21 ENST00000290722.1
PGLYRP3
peptidoglycan recognition protein 3
chrY_-_13524717 0.21 ENST00000331172.6
SLC9B1P1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 pseudogene 1
chr8_-_29605625 0.21 ENST00000506121.3
LINC00589
long intergenic non-protein coding RNA 589
chr14_-_80697396 0.20 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chr15_+_98503922 0.20 ENST00000268042.6
ARRDC4
arrestin domain containing 4
chr17_-_73401567 0.20 ENST00000392562.1
GRB2
growth factor receptor-bound protein 2
chrX_+_15525426 0.20 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr16_+_21716284 0.20 ENST00000388957.3
OTOA
otoancorin
chr17_+_40925454 0.19 ENST00000253794.2
ENST00000590339.1
ENST00000589520.1
VPS25
vacuolar protein sorting 25 homolog (S. cerevisiae)
chr4_-_119759795 0.19 ENST00000419654.2
SEC24D
SEC24 family member D
chr3_-_155572164 0.18 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_-_11374904 0.18 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr19_-_6393216 0.18 ENST00000595047.1
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr1_-_13452656 0.18 ENST00000376132.3
PRAMEF13
PRAME family member 13
chr5_+_140723601 0.18 ENST00000253812.6
PCDHGA3
protocadherin gamma subfamily A, 3
chr1_-_13117736 0.18 ENST00000376192.5
ENST00000376182.1
PRAMEF6
PRAME family member 6
chr6_-_133055896 0.18 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr2_+_169923504 0.17 ENST00000357546.2
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_-_89927151 0.17 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_-_74663825 0.17 ENST00000370911.3
ENST00000370909.2
ENST00000354431.4
LRRIQ3
leucine-rich repeats and IQ motif containing 3
chrX_-_68385274 0.17 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr6_+_35996859 0.17 ENST00000472333.1
MAPK14
mitogen-activated protein kinase 14
chr4_-_100575781 0.17 ENST00000511828.1
RP11-766F14.2
Protein LOC285556
chr6_-_26199499 0.17 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr11_+_55650773 0.16 ENST00000449290.2
TRIM51
tripartite motif-containing 51
chr2_-_86333244 0.16 ENST00000263857.6
ENST00000409681.1
POLR1A
polymerase (RNA) I polypeptide A, 194kDa
chr17_+_7476136 0.16 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr5_+_98109322 0.16 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chr5_+_101569696 0.16 ENST00000597120.1
AC008948.1
AC008948.1
chr6_+_26251835 0.16 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr4_-_46126093 0.16 ENST00000295452.4
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr7_+_93535866 0.16 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr12_-_114211444 0.16 ENST00000510694.2
ENST00000550223.1
RP11-438N16.1
RP11-438N16.1
chr1_-_157811588 0.16 ENST00000368174.4
CD5L
CD5 molecule-like
chr4_+_146539415 0.16 ENST00000281317.5
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr11_+_30253410 0.16 ENST00000533718.1
FSHB
follicle stimulating hormone, beta polypeptide
chr1_-_117210290 0.15 ENST00000369483.1
ENST00000369486.3
IGSF3
immunoglobulin superfamily, member 3
chr6_-_66417107 0.15 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr6_+_167704798 0.15 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr10_-_29811456 0.15 ENST00000535393.1
SVIL
supervillin
chrX_-_72095808 0.15 ENST00000373529.5
DMRTC1
DMRT-like family C1
chr6_+_167704838 0.15 ENST00000366829.2
UNC93A
unc-93 homolog A (C. elegans)
chr11_-_85376121 0.15 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr14_-_30766223 0.15 ENST00000549360.1
ENST00000508469.2
CTD-2251F13.1
CTD-2251F13.1
chr17_-_2996290 0.14 ENST00000331459.1
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr3_-_128186091 0.14 ENST00000319153.3
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr2_+_54342533 0.14 ENST00000406041.1
ACYP2
acylphosphatase 2, muscle type
chrX_+_11311533 0.14 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr14_+_20937538 0.14 ENST00000361505.5
ENST00000553591.1
PNP
purine nucleoside phosphorylase
chr1_+_13641973 0.14 ENST00000330087.5
PRAMEF15
PRAME family member 15
chrX_-_48980098 0.14 ENST00000156109.5
GPKOW
G patch domain and KOW motifs
chr1_-_13673511 0.13 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chr2_-_105030466 0.13 ENST00000449772.1
AC068535.3
AC068535.3
chr7_+_93535817 0.13 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr6_-_26199471 0.13 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr1_+_158323634 0.13 ENST00000452291.2
ENST00000368165.3
ENST00000368166.3
ENST00000368163.3
ENST00000368164.3
CD1E
CD1e molecule
chr19_-_3061397 0.13 ENST00000586839.1
AES
amino-terminal enhancer of split
chr11_+_13690249 0.13 ENST00000532701.1
FAR1
fatty acyl CoA reductase 1
chr1_+_117963209 0.13 ENST00000449370.2
MAN1A2
mannosidase, alpha, class 1A, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of DUXA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.5 2.2 GO:0055099 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
0.5 3.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 3.0 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2 1.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 0.7 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.2 0.6 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.2 0.8 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.2 0.5 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.6 GO:0015692 lead ion transport(GO:0015692)
0.1 1.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 1.9 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.9 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.6 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.3 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.1 0.5 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.1 0.3 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.2 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.2 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.1 0.4 GO:0030035 microspike assembly(GO:0030035)
0.1 0.6 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 1.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 0.4 GO:0042746 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.1 0.2 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.3 GO:1904209 maintenance of blood-brain barrier(GO:0035633) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0006738 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.0 0.1 GO:1904397 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.5 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.4 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.7 GO:2000480 negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.3 GO:0048478 replication fork protection(GO:0048478)
0.0 1.2 GO:0042730 fibrinolysis(GO:0042730)
0.0 1.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.5 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.1 GO:1901420 negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.4 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.2 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.0 0.6 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.2 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.3 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.0 GO:0033121 regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0055096 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.3 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0043335 protein unfolding(GO:0043335)
0.0 1.2 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 0.6 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.6 GO:0097452 GAIT complex(GO:0097452)
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.1 0.2 GO:0000814 ESCRT II complex(GO:0000814)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.7 2.2 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.5 3.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 0.6 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.2 0.6 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.6 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.6 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.1 0.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 3.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.4 GO:0016499 orexin receptor activity(GO:0016499)
0.1 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 1.0 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0017129 triglyceride binding(GO:0017129)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.3 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.4 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.0 GO:0016160 amylase activity(GO:0016160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.4 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 2.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 3.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 4.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.6 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 3.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling