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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for E2F2_E2F5
Z-value: 1.00
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | -0.22 | 3.0e-01 | Click! |
| E2F5 | hg19_v2_chr8_+_86121448_86121494 | -0.06 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_62538089 Show fit | 1.72 |
ENST00000519078.2
ENST00000395284.3 ENST00000316629.4 |
cyclin-dependent kinase 1 |
|
| chr10_+_62538248 Show fit | 1.64 |
ENST00000448257.2
|
cyclin-dependent kinase 1 |
|
| chr20_+_25388293 Show fit | 1.48 |
ENST00000262460.4
ENST00000429262.2 |
GINS complex subunit 1 (Psf1 homolog) |
|
| chr15_-_64673630 Show fit | 1.46 |
ENST00000558008.1
ENST00000559519.1 ENST00000380258.2 |
KIAA0101 |
|
| chr2_+_10262857 Show fit | 1.19 |
ENST00000304567.5
|
ribonucleotide reductase M2 |
|
| chr5_-_79950371 Show fit | 1.12 |
ENST00000511032.1
ENST00000504396.1 ENST00000505337.1 |
dihydrofolate reductase |
|
| chr5_-_79950775 Show fit | 1.07 |
ENST00000439211.2
|
dihydrofolate reductase |
|
| chr3_+_44803209 Show fit | 1.06 |
ENST00000326047.4
|
kinesin family member 15 |
|
| chr8_-_124408652 Show fit | 1.03 |
ENST00000287394.5
|
ATPase family, AAA domain containing 2 |
|
| chr15_-_64673665 Show fit | 1.01 |
ENST00000300035.4
|
KIAA0101 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.6 | 3.4 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 0.3 | 2.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.2 | 2.4 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.5 | 2.2 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.6 | 1.8 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.0 | 1.7 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.1 | 1.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.0 | 1.1 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 1.0 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.7 | 3.4 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.4 | 1.7 | GO:0000811 | GINS complex(GO:0000811) |
| 0.3 | 1.4 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.4 | 1.1 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.2 | 1.1 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 1.1 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.1 | 1.1 | GO:0000796 | condensin complex(GO:0000796) |
| 0.2 | 1.0 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.1 | 0.8 | GO:0000124 | SAGA complex(GO:0000124) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.2 | 2.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.4 | 2.2 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 1.7 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 1.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 1.5 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.3 | 1.4 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 1.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.2 | 0.8 | GO:0032142 | single guanine insertion binding(GO:0032142) |
| 0.1 | 0.8 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 3.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.4 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 6.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 1.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.1 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.0 | 0.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 0.7 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.7 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 0.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.6 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.0 | 0.4 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |