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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for E2F2_E2F5

Z-value: 1.00

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Transcription factors associated with E2F2_E2F5

Gene Symbol Gene ID Gene Info
E2F2
ENSG00000007968.6 E2F transcription factor 2
E2F5
ENSG00000133740.6 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F2hg19_v2_chr1_-_23857698_23857733-0.223.0e-01Click!
E2F5hg19_v2_chr8_+_86121448_86121494-0.067.9e-01Click!

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_62538089 1.72 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr10_+_62538248 1.64 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr20_+_25388293 1.48 ENST00000262460.4
ENST00000429262.2
GINS1
GINS complex subunit 1 (Psf1 homolog)
chr15_-_64673630 1.46 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr2_+_10262857 1.19 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr5_-_79950371 1.12 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
DHFR
dihydrofolate reductase
chr5_-_79950775 1.07 ENST00000439211.2
DHFR
dihydrofolate reductase
chr3_+_44803209 1.06 ENST00000326047.4
KIF15
kinesin family member 15
chr8_-_124408652 1.03 ENST00000287394.5
ATAD2
ATPase family, AAA domain containing 2
chr15_-_64673665 1.01 ENST00000300035.4
KIAA0101
KIAA0101
chr3_+_127317066 0.86 ENST00000265056.7
MCM2
minichromosome maintenance complex component 2
chr1_-_47779762 0.85 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr17_-_42277203 0.80 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr16_-_3030283 0.78 ENST00000572619.1
ENST00000574415.1
ENST00000440027.2
ENST00000572059.1
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr1_+_145209092 0.76 ENST00000362074.6
ENST00000344859.3
NOTCH2NL
notch 2 N-terminal like
chr1_-_120612240 0.71 ENST00000256646.2
NOTCH2
notch 2
chr14_-_50154921 0.70 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr22_+_35796056 0.69 ENST00000216122.4
MCM5
minichromosome maintenance complex component 5
chr22_+_35796108 0.69 ENST00000382011.5
ENST00000416905.1
MCM5
minichromosome maintenance complex component 5
chr11_-_19262486 0.68 ENST00000250024.4
E2F8
E2F transcription factor 8
chr12_-_77459306 0.67 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
E2F7
E2F transcription factor 7
chr1_-_36235559 0.66 ENST00000251195.5
CLSPN
claspin
chr16_-_3030407 0.66 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr14_+_21538517 0.64 ENST00000298693.3
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr9_-_99180597 0.62 ENST00000375256.4
ZNF367
zinc finger protein 367
chr7_-_158497431 0.61 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
NCAPG2
non-SMC condensin II complex, subunit G2
chr2_+_174219548 0.60 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
CDCA7
cell division cycle associated 7
chr15_-_66649010 0.58 ENST00000367709.4
ENST00000261881.4
TIPIN
TIMELESS interacting protein
chr20_-_5931051 0.57 ENST00000453074.2
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr10_+_96305535 0.55 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
HELLS
helicase, lymphoid-specific
chr10_+_13203543 0.54 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr7_-_99699538 0.54 ENST00000343023.6
ENST00000303887.5
MCM7
minichromosome maintenance complex component 7
chr15_+_32907691 0.53 ENST00000361627.3
ENST00000567348.1
ENST00000563864.1
ENST00000543522.1
ARHGAP11A
Rho GTPase activating protein 11A
chr10_+_112327425 0.52 ENST00000361804.4
SMC3
structural maintenance of chromosomes 3
chr14_+_21538429 0.49 ENST00000298694.4
ENST00000555038.1
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr13_-_26625169 0.47 ENST00000319420.3
SHISA2
shisa family member 2
chr6_+_27833034 0.46 ENST00000357320.2
HIST1H2AL
histone cluster 1, H2al
chr11_-_19263145 0.45 ENST00000532666.1
ENST00000527884.1
E2F8
E2F transcription factor 8
chr14_+_36295638 0.44 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr4_+_154265784 0.43 ENST00000240488.3
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chrX_+_24711997 0.42 ENST00000379068.3
ENST00000379059.3
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr1_+_13910479 0.41 ENST00000509009.1
PDPN
podoplanin
chr6_+_24775153 0.41 ENST00000356509.3
ENST00000230056.3
GMNN
geminin, DNA replication inhibitor
chr20_-_5931109 0.41 ENST00000203001.2
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr8_+_48873453 0.40 ENST00000523944.1
MCM4
minichromosome maintenance complex component 4
chr8_+_48873479 0.40 ENST00000262105.2
MCM4
minichromosome maintenance complex component 4
chr2_-_47168850 0.38 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chr13_+_45694583 0.38 ENST00000340473.6
GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr1_+_228645796 0.38 ENST00000369160.2
HIST3H2BB
histone cluster 3, H2bb
chr2_+_75185619 0.37 ENST00000483063.1
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr2_+_48010221 0.37 ENST00000234420.5
MSH6
mutS homolog 6
chr12_+_109535923 0.36 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr8_-_98290087 0.36 ENST00000322128.3
TSPYL5
TSPY-like 5
chr7_-_148581360 0.36 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr4_-_174256276 0.35 ENST00000296503.5
HMGB2
high mobility group box 2
chr5_+_133861790 0.35 ENST00000395003.1
PHF15
jade family PHD finger 2
chr1_-_23670752 0.35 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr7_+_26241310 0.35 ENST00000396386.2
CBX3
chromobox homolog 3
chr2_-_232329186 0.34 ENST00000322723.4
NCL
nucleolin
chr2_+_48010312 0.34 ENST00000540021.1
MSH6
mutS homolog 6
chr19_-_36705547 0.34 ENST00000304116.5
ZNF565
zinc finger protein 565
chr7_-_148581251 0.33 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr9_-_35080013 0.33 ENST00000378643.3
FANCG
Fanconi anemia, complementation group G
chr1_+_212208919 0.32 ENST00000366991.4
ENST00000542077.1
DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr1_-_100598444 0.32 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chrX_+_123095546 0.32 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr7_-_105516923 0.32 ENST00000478915.1
ATXN7L1
ataxin 7-like 1
chr10_-_25241499 0.31 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
PRTFDC1
phosphoribosyl transferase domain containing 1
chr16_-_30102547 0.30 ENST00000279386.2
TBX6
T-box 6
chr19_-_45909585 0.30 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr7_+_99699280 0.29 ENST00000421755.1
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr13_+_32889605 0.29 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
BRCA2
breast cancer 2, early onset
chr11_+_47236489 0.29 ENST00000256996.4
ENST00000378603.3
ENST00000378600.3
ENST00000378601.3
DDB2
damage-specific DNA binding protein 2, 48kDa
chr20_-_5100591 0.29 ENST00000379143.5
PCNA
proliferating cell nuclear antigen
chr7_+_120591170 0.28 ENST00000431467.1
ING3
inhibitor of growth family, member 3
chr2_-_17935059 0.28 ENST00000448223.2
ENST00000381272.4
ENST00000351948.4
SMC6
structural maintenance of chromosomes 6
chr2_-_136633940 0.28 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr1_-_23670813 0.28 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr9_-_140484917 0.28 ENST00000298585.2
ZMYND19
zinc finger, MYND-type containing 19
chr7_+_26241325 0.27 ENST00000456948.1
ENST00000409747.1
CBX3
chromobox homolog 3
chr8_-_120868078 0.27 ENST00000313655.4
DSCC1
DNA replication and sister chromatid cohesion 1
chr3_+_10068095 0.27 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr5_+_56469843 0.26 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr15_+_40987327 0.26 ENST00000423169.2
ENST00000267868.3
ENST00000557850.1
ENST00000532743.1
ENST00000382643.3
RAD51
RAD51 recombinase
chr5_+_36152179 0.26 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr9_+_106856831 0.26 ENST00000303219.8
ENST00000374787.3
SMC2
structural maintenance of chromosomes 2
chr10_-_58120996 0.26 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZWINT
ZW10 interacting kinetochore protein
chr9_+_106856541 0.26 ENST00000286398.7
ENST00000440179.1
ENST00000374793.3
SMC2
structural maintenance of chromosomes 2
chr15_-_70388943 0.26 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr3_-_53080047 0.26 ENST00000482396.1
ENST00000358080.2
ENST00000296295.6
ENST00000394752.3
SFMBT1
Scm-like with four mbt domains 1
chr19_+_36706024 0.25 ENST00000443387.2
ZNF146
zinc finger protein 146
chr11_+_4116054 0.25 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chrX_+_131157290 0.25 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr11_+_125495862 0.25 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
CHEK1
checkpoint kinase 1
chr2_+_232573222 0.25 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr9_-_123639445 0.25 ENST00000312189.6
PHF19
PHD finger protein 19
chrX_+_46696372 0.25 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr19_+_36705504 0.24 ENST00000456324.1
ZNF146
zinc finger protein 146
chrX_+_131157322 0.24 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr15_+_44719970 0.24 ENST00000558966.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr6_-_52149475 0.24 ENST00000419835.2
ENST00000229854.7
ENST00000596288.1
MCM3
minichromosome maintenance complex component 3
chr5_+_56469775 0.24 ENST00000424459.3
GPBP1
GC-rich promoter binding protein 1
chr2_+_16080659 0.24 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr2_-_96700664 0.24 ENST00000359548.4
ENST00000377137.3
ENST00000439254.1
ENST00000453542.1
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr22_+_20104947 0.24 ENST00000402752.1
RANBP1
RAN binding protein 1
chr11_-_95522907 0.24 ENST00000358780.5
ENST00000542135.1
FAM76B
family with sequence similarity 76, member B
chr9_+_86595626 0.23 ENST00000445877.1
ENST00000325875.3
RMI1
RecQ mediated genome instability 1
chr22_+_31031639 0.23 ENST00000343605.4
ENST00000300385.8
SLC35E4
solute carrier family 35, member E4
chr2_+_27498289 0.22 ENST00000296097.3
ENST00000420191.1
DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr1_-_91487013 0.22 ENST00000347275.5
ENST00000370440.1
ZNF644
zinc finger protein 644
chr6_-_30181156 0.22 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr6_-_30181133 0.22 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chrX_-_106243451 0.21 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr2_+_27498331 0.21 ENST00000402462.1
ENST00000404433.1
ENST00000406962.1
DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr5_+_75379224 0.20 ENST00000322285.7
SV2C
synaptic vesicle glycoprotein 2C
chr1_+_53925063 0.20 ENST00000371445.3
DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr16_-_85722530 0.18 ENST00000253462.3
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr12_-_31479107 0.18 ENST00000542983.1
FAM60A
family with sequence similarity 60, member A
chr8_-_67525473 0.18 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr6_+_135502408 0.18 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr1_-_23670817 0.18 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr6_+_27775899 0.18 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr7_+_120590803 0.17 ENST00000315870.5
ENST00000339121.5
ENST00000445699.1
ING3
inhibitor of growth family, member 3
chr1_-_205719295 0.17 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr19_-_10305752 0.17 ENST00000540357.1
ENST00000359526.4
ENST00000340748.4
DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr16_+_58426296 0.17 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS3
GINS complex subunit 3 (Psf3 homolog)
chr5_+_43120985 0.17 ENST00000515326.1
ZNF131
zinc finger protein 131
chr11_-_95522639 0.17 ENST00000536839.1
FAM76B
family with sequence similarity 76, member B
chr5_+_74062806 0.17 ENST00000296802.5
NSA2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr2_-_235405679 0.17 ENST00000390645.2
ARL4C
ADP-ribosylation factor-like 4C
chr5_+_79950463 0.17 ENST00000265081.6
MSH3
mutS homolog 3
chr20_-_62258394 0.17 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr7_-_44887620 0.17 ENST00000349299.3
ENST00000521529.1
ENST00000308153.4
ENST00000350771.3
ENST00000222690.6
ENST00000381124.5
ENST00000437072.1
ENST00000446531.1
H2AFV
H2A histone family, member V
chrX_-_45710920 0.17 ENST00000456532.1
RP5-1158E12.3
RP5-1158E12.3
chr7_-_27169801 0.17 ENST00000511914.1
HOXA4
homeobox A4
chr11_-_74442430 0.16 ENST00000376332.3
CHRDL2
chordin-like 2
chr1_-_26232951 0.16 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr2_-_47168906 0.16 ENST00000444761.2
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2
chr6_+_135502466 0.16 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr6_-_27114577 0.16 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr1_+_25599018 0.16 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr2_+_232573208 0.16 ENST00000409115.3
PTMA
prothymosin, alpha
chr7_+_99699179 0.15 ENST00000438383.1
ENST00000429084.1
ENST00000359593.4
ENST00000439416.1
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr16_-_4323015 0.15 ENST00000204517.6
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr17_-_42580738 0.15 ENST00000585614.1
ENST00000591680.1
ENST00000434000.1
ENST00000588554.1
ENST00000592154.1
GPATCH8
G patch domain containing 8
chr5_+_56469939 0.15 ENST00000506184.2
GPBP1
GC-rich promoter binding protein 1
chr20_+_5931275 0.15 ENST00000378896.3
ENST00000378883.1
MCM8
minichromosome maintenance complex component 8
chr12_-_122238913 0.15 ENST00000537157.1
AC084018.1
AC084018.1
chrX_+_100353153 0.15 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
CENPI
centromere protein I
chr18_-_70210764 0.15 ENST00000585159.1
ENST00000584764.1
CBLN2
cerebellin 2 precursor
chr4_-_130014729 0.14 ENST00000281142.5
ENST00000434680.1
SCLT1
sodium channel and clathrin linker 1
chr3_-_49893958 0.14 ENST00000482243.1
ENST00000331456.2
ENST00000469027.1
TRAIP
TRAF interacting protein
chr7_+_6048856 0.14 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr7_+_90225796 0.14 ENST00000380050.3
CDK14
cyclin-dependent kinase 14
chr7_+_26240776 0.14 ENST00000337620.4
CBX3
chromobox homolog 3
chr9_+_82186682 0.14 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_-_122238464 0.14 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr17_+_74380683 0.14 ENST00000592299.1
ENST00000590959.1
ENST00000323374.4
SPHK1
sphingosine kinase 1
chr6_+_30312908 0.14 ENST00000433076.2
ENST00000442966.2
ENST00000428040.2
ENST00000436442.2
RPP21
ribonuclease P/MRP 21kDa subunit
chr3_+_41240925 0.14 ENST00000396183.3
ENST00000349496.5
ENST00000453024.1
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa
chr3_-_44803141 0.14 ENST00000296121.4
KIAA1143
KIAA1143
chr6_-_27782548 0.14 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr21_-_30365136 0.13 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
LTN1
listerin E3 ubiquitin protein ligase 1
chr2_-_27632390 0.13 ENST00000350803.4
ENST00000344034.4
PPM1G
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr1_+_6845384 0.13 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr6_+_27100811 0.13 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr18_+_19192228 0.13 ENST00000300413.5
ENST00000579618.1
ENST00000582475.1
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr1_-_229694406 0.13 ENST00000344517.4
ABCB10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr20_-_60982330 0.13 ENST00000279101.5
CABLES2
Cdk5 and Abl enzyme substrate 2
chr5_+_138629337 0.12 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
MATR3
matrin 3
chr22_+_29138013 0.12 ENST00000216027.3
ENST00000398941.2
HSCB
HscB mitochondrial iron-sulfur cluster co-chaperone
chr17_-_56065484 0.12 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr17_+_27717415 0.12 ENST00000583121.1
ENST00000261716.3
TAOK1
TAO kinase 1
chr4_-_130014705 0.12 ENST00000503401.1
SCLT1
sodium channel and clathrin linker 1
chr1_+_222988464 0.12 ENST00000420335.1
RP11-452F19.3
RP11-452F19.3
chr2_+_17935119 0.12 ENST00000317402.7
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr3_-_133380731 0.12 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr4_-_130014609 0.11 ENST00000511426.1
SCLT1
sodium channel and clathrin linker 1
chr4_-_130014532 0.11 ENST00000506368.1
ENST00000439369.2
ENST00000503215.1
SCLT1
sodium channel and clathrin linker 1
chr5_+_138629417 0.11 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
MATR3
matrin 3
chr2_+_17935383 0.11 ENST00000524465.1
ENST00000381254.2
ENST00000532257.1
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr15_+_71184931 0.11 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chr15_+_66994663 0.11 ENST00000457357.2
SMAD6
SMAD family member 6
chr1_+_222885884 0.11 ENST00000340934.5
BROX
BRO1 domain and CAAX motif containing
chr12_-_2113583 0.11 ENST00000397173.4
ENST00000280665.6
DCP1B
decapping mRNA 1B
chrX_-_152736013 0.11 ENST00000330912.2
ENST00000338525.2
ENST00000334497.2
ENST00000370232.1
ENST00000370212.3
ENST00000370211.4
TREX2
HAUS7
three prime repair exonuclease 2
HAUS augmin-like complex, subunit 7
chr5_+_138629389 0.10 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
MATR3
matrin 3
chr14_+_75348592 0.10 ENST00000334220.4
DLST
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr3_+_52719936 0.10 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr4_+_71859156 0.10 ENST00000286648.5
ENST00000504730.1
ENST00000504952.1
DCK
deoxycytidine kinase
chr6_+_88299833 0.10 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr1_+_179262905 0.10 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr1_-_212208842 0.10 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
INTS7
integrator complex subunit 7
chr19_-_6502590 0.10 ENST00000264071.2
TUBB4A
tubulin, beta 4A class IVa
chr20_+_5931497 0.10 ENST00000378886.2
ENST00000265187.4
MCM8
minichromosome maintenance complex component 8
chr1_+_100598691 0.10 ENST00000370143.1
ENST00000370141.2
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr3_+_57261743 0.10 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr10_-_77161650 0.10 ENST00000372524.4
ZNF503
zinc finger protein 503
chr9_-_123639600 0.10 ENST00000373896.3
PHF19
PHD finger protein 19
chr1_-_26232522 0.09 ENST00000399728.1
STMN1
stathmin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.6 3.4 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.5 2.2 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.3 2.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 0.7 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2 0.4 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.2 0.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.2 0.7 GO:0006272 leading strand elongation(GO:0006272)
0.2 2.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.4 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.8 GO:0033504 floor plate development(GO:0033504)
0.1 1.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.3 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.1 0.7 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.6 GO:0048478 replication fork protection(GO:0048478)
0.1 0.2 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.1 3.9 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.2 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.5 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1 0.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 0.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 1.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.3 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.1 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.2 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.1 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 0.1 GO:0072054 negative regulation of mitotic cell cycle, embryonic(GO:0045976) renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) positive regulation of determination of dorsal identity(GO:2000017)
0.0 0.1 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.0 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 0.2 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.3 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.3 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.1 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 1.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.8 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.3 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.1 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.1 GO:0070632 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.8 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.4 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.4 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.1 GO:0031291 Ran protein signal transduction(GO:0031291)
0.0 0.4 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.0 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.3 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 1.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0 0.1 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.0 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.0 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.0 0.1 GO:0048104 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.0 0.0 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.0 GO:0002184 cytoplasmic translational termination(GO:0002184)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.4 1.7 GO:0000811 GINS complex(GO:0000811)
0.4 1.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.3 1.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 4.4 GO:0042555 MCM complex(GO:0042555)
0.2 1.0 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.2 1.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.2 0.7 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.4 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 1.1 GO:0031298 replication fork protection complex(GO:0031298)
0.1 1.1 GO:0000796 condensin complex(GO:0000796)
0.1 0.5 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 0.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.6 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.3 GO:0098536 deuterosome(GO:0098536)
0.1 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.2 GO:1990075 periciliary membrane compartment(GO:1990075)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.0 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.7 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.6 GO:0000800 lateral element(GO:0000800)
0.0 0.5 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.7 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.0 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.0 GO:0018444 translation release factor complex(GO:0018444)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0051870 methotrexate binding(GO:0051870)
0.3 1.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 2.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 0.8 GO:0032142 single guanine insertion binding(GO:0032142)
0.1 0.3 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.1 3.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.7 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 0.7 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.1 0.8 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.3 GO:0036033 mediator complex binding(GO:0036033)
0.1 0.7 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.4 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.1 0.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.3 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.5 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 1.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.4 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 1.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.4 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.1 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.1 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.0 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.7 PID ATR PATHWAY ATR signaling pathway
0.0 3.8 PID E2F PATHWAY E2F transcription factor network
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID AURORA B PATHWAY Aurora B signaling
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.4 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 7.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.9 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.1 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.1 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.0 0.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME MEIOSIS Genes involved in Meiosis