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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for E2F3
Z-value: 1.41
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Transcription factors associated with E2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg19_v2_chr6_+_20403997_20404034 | 0.04 | 8.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 11.5 | GO:0097461 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 2.5 | 10.2 | GO:2000690 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.6 | 6.1 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 0.2 | 5.5 | GO:0072189 | ureter development(GO:0072189) |
| 1.2 | 4.8 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.3 | 4.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 4.1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 1.3 | 4.0 | GO:0035915 | pore formation in membrane of other organism(GO:0035915) |
| 0.0 | 4.0 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.4 | 3.8 | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.3 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 7.1 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 5.2 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 4.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 4.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 4.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 3.8 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.3 | 3.4 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 3.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 11.8 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 6.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.2 | 5.4 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.0 | 4.6 | GO:0005179 | hormone activity(GO:0005179) |
| 1.0 | 4.0 | GO:0061769 | ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769) |
| 1.2 | 3.5 | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829) |
| 0.7 | 3.4 | GO:0052833 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.6 | 3.2 | GO:0004306 | ethanolamine-phosphate cytidylyltransferase activity(GO:0004306) |
| 0.1 | 3.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.3 | 3.0 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 3.2 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 3.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 3.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.7 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 2.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 2.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 5.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 5.5 | REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | Genes involved in NCAM signaling for neurite out-growth |
| 0.1 | 4.6 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 4.6 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.0 | 4.5 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.2 | 4.3 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 3.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 3.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 3.3 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |