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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for E2F4
Z-value: 0.75
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Transcription factors associated with E2F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F4 | hg19_v2_chr16_+_67226019_67226127 | 0.17 | 4.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_203736150 Show fit | 1.79 |
ENST00000457524.1
ENST00000421334.1 |
islet cell autoantigen 1,69kDa-like |
|
| chr4_-_157892167 Show fit | 1.15 |
ENST00000541126.1
|
platelet derived growth factor C |
|
| chr19_+_18284477 Show fit | 1.06 |
ENST00000407280.3
|
interferon, gamma-inducible protein 30 |
|
| chr12_-_57472522 Show fit | 1.04 |
ENST00000379391.3
ENST00000300128.4 |
transmembrane protein 194A |
|
| chr4_-_157892498 Show fit | 0.98 |
ENST00000502773.1
|
platelet derived growth factor C |
|
| chr2_-_133427767 Show fit | 0.95 |
ENST00000397463.2
|
LY6/PLAUR domain containing 1 |
|
| chr9_+_35732312 Show fit | 0.94 |
ENST00000353704.2
|
cAMP responsive element binding protein 3 |
|
| chr14_+_21538517 Show fit | 0.91 |
ENST00000298693.3
|
Rho guanine nucleotide exchange factor (GEF) 40 |
|
| chr10_-_62493223 Show fit | 0.90 |
ENST00000373827.2
|
ankyrin 3, node of Ranvier (ankyrin G) |
|
| chr4_-_157892055 Show fit | 0.90 |
ENST00000422544.2
|
platelet derived growth factor C |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 0.0 | 2.6 | GO:0007286 | spermatid development(GO:0007286) |
| 0.1 | 1.4 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.4 | 1.3 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.2 | 1.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.1 | 1.1 | GO:0098795 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.3 | 1.0 | GO:0060380 | regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) |
| 0.3 | 0.9 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 0.2 | 0.9 | GO:1900827 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.2 | 0.9 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 2.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 1.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 1.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 1.1 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 1.0 | GO:0070187 | telosome(GO:0070187) |
| 0.1 | 1.0 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.9 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.2 | 0.8 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 0.8 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 2.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 1.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 1.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 1.3 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 1.3 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.1 | 1.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 1.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 1.1 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.3 | 0.9 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.4 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.3 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 1.2 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 1.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.2 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.0 | 1.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 1.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |