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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for E2F4

Z-value: 0.75

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Transcription factors associated with E2F4

Gene Symbol Gene ID Gene Info
E2F4
ENSG00000205250.4 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F4hg19_v2_chr16_+_67226019_672261270.174.2e-01Click!

Activity profile of E2F4 motif

Sorted Z-values of E2F4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_203736150 1.79 ENST00000457524.1
ENST00000421334.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr4_-_157892167 1.15 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr19_+_18284477 1.06 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr12_-_57472522 1.04 ENST00000379391.3
ENST00000300128.4
TMEM194A
transmembrane protein 194A
chr4_-_157892498 0.98 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr2_-_133427767 0.95 ENST00000397463.2
LYPD1
LY6/PLAUR domain containing 1
chr9_+_35732312 0.94 ENST00000353704.2
CREB3
cAMP responsive element binding protein 3
chr14_+_21538517 0.91 ENST00000298693.3
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr10_-_62493223 0.90 ENST00000373827.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_157892055 0.90 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr12_-_77459306 0.87 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
E2F7
E2F transcription factor 7
chr19_-_6424783 0.83 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr14_+_21538429 0.76 ENST00000298694.4
ENST00000555038.1
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr7_-_108096765 0.74 ENST00000379024.4
ENST00000351718.4
NRCAM
neuronal cell adhesion molecule
chr11_+_82612740 0.72 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82
chromosome 11 open reading frame 82
chr7_-_108096822 0.69 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM
neuronal cell adhesion molecule
chr10_+_122216316 0.66 ENST00000398250.1
ENST00000439221.1
ENST00000398248.1
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr17_+_43238438 0.66 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr4_+_74702214 0.63 ENST00000226317.5
ENST00000515050.1
CXCL6
chemokine (C-X-C motif) ligand 6
chr15_+_92937144 0.63 ENST00000539113.1
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr7_+_138145145 0.62 ENST00000415680.2
TRIM24
tripartite motif containing 24
chr3_-_113415441 0.61 ENST00000491165.1
ENST00000316407.4
KIAA2018
KIAA2018
chr9_-_21994344 0.60 ENST00000530628.2
ENST00000361570.3
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr8_-_119964434 0.60 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr4_-_120549163 0.60 ENST00000394439.1
ENST00000420633.1
PDE5A
phosphodiesterase 5A, cGMP-specific
chr15_+_91260552 0.60 ENST00000355112.3
ENST00000560509.1
BLM
Bloom syndrome, RecQ helicase-like
chr1_-_197115818 0.59 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr8_+_124084899 0.54 ENST00000287380.1
ENST00000309336.3
ENST00000519418.1
ENST00000327098.5
ENST00000522420.1
ENST00000521676.1
ENST00000378080.2
TBC1D31
TBC1 domain family, member 31
chr4_-_1714037 0.54 ENST00000488267.1
ENST00000429429.2
ENST00000480936.1
SLBP
stem-loop binding protein
chr14_-_55658323 0.53 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr7_+_138145076 0.53 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr11_-_34379546 0.53 ENST00000435224.2
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr1_+_113217345 0.53 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr4_-_2758015 0.53 ENST00000510267.1
ENST00000503235.1
ENST00000315423.7
TNIP2
TNFAIP3 interacting protein 2
chr1_+_113217309 0.52 ENST00000544796.1
ENST00000369644.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr16_+_50776021 0.52 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr21_-_44496441 0.52 ENST00000359624.3
ENST00000352178.5
CBS
cystathionine-beta-synthase
chr5_+_148521381 0.52 ENST00000504238.1
ABLIM3
actin binding LIM protein family, member 3
chr6_-_137113604 0.51 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr2_+_154728426 0.50 ENST00000392825.3
ENST00000434213.1
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr12_+_49717019 0.49 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
TROAP
trophinin associated protein
chr6_+_45389893 0.49 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chr1_-_28241024 0.49 ENST00000313433.7
ENST00000444045.1
RPA2
replication protein A2, 32kDa
chr1_-_226496898 0.49 ENST00000481685.1
LIN9
lin-9 homolog (C. elegans)
chr11_+_58910295 0.48 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr19_-_10444188 0.48 ENST00000293677.6
RAVER1
ribonucleoprotein, PTB-binding 1
chr1_-_229761717 0.48 ENST00000366675.3
ENST00000258281.2
ENST00000366674.1
TAF5L
TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chrX_+_30671476 0.47 ENST00000378946.3
ENST00000378943.3
ENST00000378945.3
ENST00000427190.1
ENST00000378941.3
GK
glycerol kinase
chr6_+_126661253 0.47 ENST00000368326.1
ENST00000368325.1
ENST00000368328.4
CENPW
centromere protein W
chr1_-_33283754 0.47 ENST00000373477.4
YARS
tyrosyl-tRNA synthetase
chr14_+_59104741 0.46 ENST00000395153.3
ENST00000335867.4
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr3_+_179280668 0.46 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr17_+_45810594 0.46 ENST00000177694.1
TBX21
T-box 21
chr1_+_184356188 0.46 ENST00000235307.6
C1orf21
chromosome 1 open reading frame 21
chr9_-_35115836 0.46 ENST00000378566.1
ENST00000378554.2
ENST00000322813.5
FAM214B
family with sequence similarity 214, member B
chr12_+_49717081 0.45 ENST00000547807.1
ENST00000551567.1
TROAP
trophinin associated protein
chr4_-_185655278 0.45 ENST00000281453.5
MLF1IP
centromere protein U
chr2_+_47168313 0.44 ENST00000319190.5
ENST00000394850.2
ENST00000536057.1
TTC7A
tetratricopeptide repeat domain 7A
chr16_+_50775971 0.44 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD
cylindromatosis (turban tumor syndrome)
chr6_-_27114577 0.44 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr16_-_67693846 0.43 ENST00000602850.1
ACD
adrenocortical dysplasia homolog (mouse)
chr2_+_71357434 0.43 ENST00000244230.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr11_-_123525289 0.42 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
SCN3B
sodium channel, voltage-gated, type III, beta subunit
chr7_-_27135591 0.42 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr6_-_139308777 0.42 ENST00000529597.1
ENST00000415951.2
ENST00000367663.4
ENST00000409812.2
REPS1
RALBP1 associated Eps domain containing 1
chr6_-_31632962 0.42 ENST00000456540.1
ENST00000445768.1
GPANK1
G patch domain and ankyrin repeats 1
chr19_-_10679697 0.42 ENST00000335766.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr3_+_133292574 0.41 ENST00000264993.3
CDV3
CDV3 homolog (mouse)
chr19_+_58694396 0.41 ENST00000326804.4
ENST00000345813.3
ENST00000424679.2
ZNF274
zinc finger protein 274
chr1_-_28241226 0.41 ENST00000373912.3
ENST00000373909.3
RPA2
replication protein A2, 32kDa
chr17_-_76183111 0.41 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
TK1
thymidine kinase 1, soluble
chr19_-_45909585 0.40 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr1_+_179262905 0.40 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr6_-_139309378 0.40 ENST00000450536.2
ENST00000258062.5
REPS1
RALBP1 associated Eps domain containing 1
chr19_-_10679644 0.39 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr6_+_43739697 0.39 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr15_+_79724858 0.39 ENST00000305428.3
KIAA1024
KIAA1024
chr1_-_44497024 0.39 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_129845313 0.39 ENST00000397622.2
TMEM209
transmembrane protein 209
chr4_-_1713977 0.38 ENST00000318386.4
SLBP
stem-loop binding protein
chr15_+_76196200 0.38 ENST00000308275.3
ENST00000453211.2
FBXO22
F-box protein 22
chr15_+_90744533 0.37 ENST00000411539.2
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr19_+_50887585 0.37 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr8_-_132052458 0.36 ENST00000377928.3
ADCY8
adenylate cyclase 8 (brain)
chr6_+_83073952 0.36 ENST00000543496.1
TPBG
trophoblast glycoprotein
chr16_+_50775948 0.35 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD
cylindromatosis (turban tumor syndrome)
chr5_-_79950371 0.35 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
DHFR
dihydrofolate reductase
chr5_-_149682447 0.35 ENST00000328668.7
ARSI
arylsulfatase family, member I
chr4_+_166794862 0.35 ENST00000513213.1
TLL1
tolloid-like 1
chr15_+_76196234 0.34 ENST00000540507.1
ENST00000565036.1
ENST00000569054.1
FBXO22
F-box protein 22
chr15_+_36871806 0.34 ENST00000566621.1
ENST00000564586.1
C15orf41
chromosome 15 open reading frame 41
chr7_+_73703728 0.34 ENST00000361545.5
ENST00000223398.6
CLIP2
CAP-GLY domain containing linker protein 2
chr18_+_33767473 0.33 ENST00000261326.5
MOCOS
molybdenum cofactor sulfurase
chr16_-_67694129 0.33 ENST00000602320.1
ACD
adrenocortical dysplasia homolog (mouse)
chr11_-_126870655 0.33 ENST00000525144.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr15_+_42841008 0.33 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr13_-_41706864 0.33 ENST00000379485.1
ENST00000499385.2
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr21_-_45660723 0.33 ENST00000344330.4
ENST00000407780.3
ENST00000400379.3
ICOSLG
inducible T-cell co-stimulator ligand
chr12_-_121734489 0.33 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr9_+_504674 0.32 ENST00000382297.2
KANK1
KN motif and ankyrin repeat domains 1
chr20_+_58508817 0.32 ENST00000358293.3
FAM217B
family with sequence similarity 217, member B
chr1_+_10490779 0.32 ENST00000477755.1
APITD1
apoptosis-inducing, TAF9-like domain 1
chr9_-_35732362 0.32 ENST00000314888.9
ENST00000540444.1
TLN1
talin 1
chr11_-_64851496 0.31 ENST00000404147.3
ENST00000275517.3
CDCA5
cell division cycle associated 5
chr5_+_156887027 0.31 ENST00000435489.2
ENST00000311946.7
NIPAL4
NIPA-like domain containing 4
chr12_-_53574671 0.31 ENST00000444623.1
CSAD
cysteine sulfinic acid decarboxylase
chr16_+_67193834 0.31 ENST00000258200.3
ENST00000518148.1
ENST00000519917.1
ENST00000517382.1
ENST00000521920.1
FBXL8
F-box and leucine-rich repeat protein 8
chr1_+_10490441 0.31 ENST00000470413.2
ENST00000309048.3
APITD1-CORT
APITD1
APITD1-CORT readthrough
apoptosis-inducing, TAF9-like domain 1
chr15_-_50647370 0.31 ENST00000558970.1
ENST00000396464.3
ENST00000560825.1
GABPB1
GA binding protein transcription factor, beta subunit 1
chr3_+_140770183 0.30 ENST00000310546.2
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr9_-_113018746 0.30 ENST00000374515.5
TXN
thioredoxin
chr3_-_27525865 0.30 ENST00000445684.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr11_-_61735103 0.30 ENST00000529191.1
ENST00000529631.1
ENST00000530019.1
ENST00000529548.1
ENST00000273550.7
FTH1
ferritin, heavy polypeptide 1
chr2_-_203736452 0.30 ENST00000419460.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr5_+_14664762 0.30 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chrX_+_109245863 0.30 ENST00000372072.3
TMEM164
transmembrane protein 164
chrX_-_110039038 0.29 ENST00000372042.1
ENST00000482160.1
ENST00000444321.2
ENST00000218054.4
CHRDL1
chordin-like 1
chr1_+_27248203 0.29 ENST00000321265.5
NUDC
nudC nuclear distribution protein
chr15_+_71184931 0.29 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chr13_+_32889605 0.29 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
BRCA2
breast cancer 2, early onset
chrX_-_110038990 0.29 ENST00000372045.1
ENST00000394797.4
CHRDL1
chordin-like 1
chr8_+_128748466 0.28 ENST00000524013.1
ENST00000520751.1
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr1_-_156647189 0.28 ENST00000368223.3
NES
nestin
chrX_-_110039286 0.28 ENST00000434224.1
CHRDL1
chordin-like 1
chr4_-_120548779 0.28 ENST00000264805.5
PDE5A
phosphodiesterase 5A, cGMP-specific
chrX_-_40594755 0.28 ENST00000324817.1
MED14
mediator complex subunit 14
chr15_+_36871983 0.28 ENST00000437989.2
ENST00000569302.1
C15orf41
chromosome 15 open reading frame 41
chr19_-_8070474 0.27 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr8_+_128748308 0.27 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr16_+_30064411 0.27 ENST00000338110.5
ALDOA
aldolase A, fructose-bisphosphate
chr4_-_119757322 0.27 ENST00000379735.5
SEC24D
SEC24 family member D
chr15_-_50647274 0.27 ENST00000543881.1
GABPB1
GA binding protein transcription factor, beta subunit 1
chr16_-_67694597 0.26 ENST00000393919.4
ENST00000219251.8
ACD
adrenocortical dysplasia homolog (mouse)
chr1_-_204654481 0.26 ENST00000367176.3
LRRN2
leucine rich repeat neuronal 2
chr16_+_30064444 0.26 ENST00000395248.1
ENST00000566897.1
ENST00000568435.1
ALDOA
aldolase A, fructose-bisphosphate
chr11_+_32914579 0.26 ENST00000399302.2
QSER1
glutamine and serine rich 1
chr1_+_109756523 0.26 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr19_-_14016877 0.25 ENST00000454313.1
ENST00000591586.1
ENST00000346736.2
C19orf57
chromosome 19 open reading frame 57
chr1_-_26185844 0.25 ENST00000538789.1
ENST00000374298.3
AUNIP
aurora kinase A and ninein interacting protein
chr15_+_71185148 0.25 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr1_+_11333245 0.25 ENST00000376810.5
UBIAD1
UbiA prenyltransferase domain containing 1
chr20_+_47662805 0.25 ENST00000262982.2
ENST00000542325.1
CSE1L
CSE1 chromosome segregation 1-like (yeast)
chr3_-_27525826 0.24 ENST00000454389.1
ENST00000440156.1
ENST00000437179.1
ENST00000446700.1
ENST00000455077.1
ENST00000435667.2
ENST00000388777.4
ENST00000425128.2
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr7_-_149158187 0.24 ENST00000247930.4
ZNF777
zinc finger protein 777
chr7_-_98741714 0.24 ENST00000361125.1
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr11_+_62623544 0.24 ENST00000377890.2
ENST00000377891.2
ENST00000377889.2
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr6_-_71666732 0.24 ENST00000230053.6
B3GAT2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr8_+_17104539 0.24 ENST00000521829.1
ENST00000521005.1
VPS37A
vacuolar protein sorting 37 homolog A (S. cerevisiae)
chr2_+_102803433 0.24 ENST00000264257.2
ENST00000441515.2
IL1RL2
interleukin 1 receptor-like 2
chr9_-_136857403 0.24 ENST00000406606.3
ENST00000371850.3
VAV2
vav 2 guanine nucleotide exchange factor
chr6_+_45390222 0.24 ENST00000359524.5
RUNX2
runt-related transcription factor 2
chr12_-_48499591 0.24 ENST00000551330.1
ENST00000004980.5
ENST00000339976.6
ENST00000448372.1
SENP1
SUMO1/sentrin specific peptidase 1
chr16_+_11038403 0.23 ENST00000409552.3
CLEC16A
C-type lectin domain family 16, member A
chr19_+_17392672 0.23 ENST00000594072.1
ENST00000598347.1
ANKLE1
ankyrin repeat and LEM domain containing 1
chr16_-_67194201 0.23 ENST00000345057.4
TRADD
TNFRSF1A-associated via death domain
chr9_-_21994597 0.23 ENST00000579755.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr3_+_10068095 0.23 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr5_+_109025067 0.23 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr3_-_122233723 0.23 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr1_+_28844778 0.23 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chrX_-_20159934 0.23 ENST00000379593.1
ENST00000379607.5
EIF1AX
eukaryotic translation initiation factor 1A, X-linked
chr3_-_169899504 0.23 ENST00000474275.1
ENST00000484931.1
ENST00000494943.1
ENST00000497658.1
ENST00000465896.1
ENST00000475729.1
ENST00000495893.2
ENST00000481639.1
ENST00000467570.1
ENST00000466189.1
PHC3
polyhomeotic homolog 3 (Drosophila)
chr16_-_4401258 0.23 ENST00000577031.1
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr11_+_62623512 0.23 ENST00000377892.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr11_+_85955787 0.22 ENST00000528180.1
EED
embryonic ectoderm development
chr11_+_62623621 0.22 ENST00000535296.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr18_-_658244 0.22 ENST00000585033.1
ENST00000323813.3
C18orf56
chromosome 18 open reading frame 56
chr1_-_145076186 0.22 ENST00000369348.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr6_-_82957433 0.22 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr1_-_10003372 0.22 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr20_-_39995467 0.21 ENST00000332312.3
EMILIN3
elastin microfibril interfacer 3
chr10_-_88281494 0.21 ENST00000298767.5
WAPAL
wings apart-like homolog (Drosophila)
chr15_-_50647347 0.21 ENST00000220429.8
ENST00000429662.2
GABPB1
GA binding protein transcription factor, beta subunit 1
chr16_+_699319 0.21 ENST00000549091.1
ENST00000293879.4
WDR90
WD repeat domain 90
chrX_+_133594168 0.21 ENST00000298556.7
HPRT1
hypoxanthine phosphoribosyltransferase 1
chr5_-_127873659 0.21 ENST00000262464.4
FBN2
fibrillin 2
chr1_-_26372602 0.21 ENST00000374278.3
ENST00000374276.3
SLC30A2
solute carrier family 30 (zinc transporter), member 2
chr13_+_95254085 0.21 ENST00000376958.4
GPR180
G protein-coupled receptor 180
chr4_-_73434498 0.20 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr19_+_16187085 0.20 ENST00000300933.4
TPM4
tropomyosin 4
chr19_-_19754404 0.20 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP
GEM interacting protein
chr2_+_178077477 0.20 ENST00000411529.2
ENST00000435711.1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr1_-_241683001 0.20 ENST00000366560.3
FH
fumarate hydratase
chr1_-_47779762 0.20 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr1_+_10490127 0.20 ENST00000602787.1
ENST00000602296.1
ENST00000400900.2
APITD1
APITD1-CORT
apoptosis-inducing, TAF9-like domain 1
APITD1-CORT readthrough
chr4_-_83821676 0.20 ENST00000355196.2
ENST00000507676.1
ENST00000506495.1
ENST00000507051.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr12_-_125052010 0.20 ENST00000458234.1
NCOR2
nuclear receptor corepressor 2
chr10_-_70166946 0.20 ENST00000388768.2
RUFY2
RUN and FYVE domain containing 2
chr1_-_204654826 0.20 ENST00000367177.3
LRRN2
leucine rich repeat neuronal 2
chr4_+_39460689 0.19 ENST00000381846.1
LIAS
lipoic acid synthetase
chr3_+_52719936 0.19 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr7_-_102985288 0.19 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr8_+_145743360 0.19 ENST00000527730.1
ENST00000529022.1
ENST00000292524.1
LRRC14
leucine rich repeat containing 14
chr19_+_797443 0.19 ENST00000394601.4
ENST00000589575.1
PTBP1
polypyrimidine tract binding protein 1
chr3_-_100120223 0.19 ENST00000284320.5
TOMM70A
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
chr1_+_151254738 0.19 ENST00000336715.6
ENST00000324048.5
ENST00000368879.2
ZNF687
zinc finger protein 687
chr7_-_99698338 0.19 ENST00000354230.3
ENST00000425308.1
MCM7
minichromosome maintenance complex component 7
chr5_+_141348721 0.19 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr17_+_73008755 0.19 ENST00000584208.1
ENST00000301585.5
ICT1
immature colon carcinoma transcript 1
chr11_+_85956182 0.19 ENST00000327320.4
ENST00000351625.6
ENST00000534595.1
EED
embryonic ectoderm development

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.3 1.0 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.3 0.9 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.2 0.9 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 0.6 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.2 0.6 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 0.9 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.2 0.6 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.2 0.5 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.2 0.9 GO:0048749 compound eye development(GO:0048749)
0.2 0.5 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.2 1.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.2 0.3 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.2 0.5 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.1 0.7 GO:0060356 leucine import(GO:0060356)
0.1 0.4 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 0.4 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 1.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.9 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.3 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.7 GO:0072757 cellular response to camptothecin(GO:0072757)
0.1 3.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.4 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.4 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 1.1 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.3 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.5 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 0.5 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.3 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.1 0.3 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.1 0.8 GO:0023035 CD40 signaling pathway(GO:0023035)
0.1 0.8 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.1 0.7 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.4 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 0.8 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.2 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.1 0.8 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.2 GO:0006106 fumarate metabolic process(GO:0006106)
0.1 0.3 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.5 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.2 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.2 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.1 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.2 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.2 GO:0009233 menaquinone metabolic process(GO:0009233)
0.0 0.5 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.4 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.0 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.3 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.0 0.2 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.3 GO:0048478 replication fork protection(GO:0048478)
0.0 0.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.1 GO:0032771 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.0 0.2 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
0.0 0.4 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.7 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.9 GO:1905145 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.5 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.5 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.3 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.4 GO:1900112 regulation of histone H3-K9 trimethylation(GO:1900112)
0.0 0.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.0 0.1 GO:0070510 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.0 0.2 GO:0033504 floor plate development(GO:0033504)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:0061055 myotome development(GO:0061055)
0.0 0.2 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.0 0.1 GO:0042097 interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.6 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.8 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.6 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.0 0.2 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.1 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.2 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.0 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 2.6 GO:0007286 spermatid development(GO:0007286)
0.0 0.3 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.5 GO:0097237 cellular response to toxic substance(GO:0097237)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.1 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.2 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0 0.5 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.0 GO:0044691 tooth eruption(GO:0044691)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.4 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.6 GO:0031076 embryonic camera-type eye development(GO:0031076)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 0.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.5 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.1 0.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 2.4 GO:0043194 axon initial segment(GO:0043194)
0.1 0.5 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.5 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.0 GO:0070187 telosome(GO:0070187)
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.2 GO:0031523 Myb complex(GO:0031523)
0.1 0.3 GO:0008278 cohesin complex(GO:0008278)
0.1 1.1 GO:0000800 lateral element(GO:0000800)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0070847 core mediator complex(GO:0070847)
0.0 0.5 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.8 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.4 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 2.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.4 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.0 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.6 GO:0031430 M band(GO:0031430)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 0.9 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.2 0.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.2 0.5 GO:0070025 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.2 0.5 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.2 0.5 GO:0004370 glycerol kinase activity(GO:0004370)
0.1 0.4 GO:0004797 thymidine kinase activity(GO:0004797)
0.1 3.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 2.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.1 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.6 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.3 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.1 0.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 1.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.9 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.3 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 0.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.3 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 0.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 1.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.2 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.2 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.9 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0048185 activin binding(GO:0048185)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.3 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 1.1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.5 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 1.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.9 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 2.2 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.3 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.5 PID AURORA A PATHWAY Aurora A signaling
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.1 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.2 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase