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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for E2F6
Z-value: 1.07
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg19_v2_chr2_-_11606275_11606289 | -0.25 | 2.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_42277203 Show fit | 7.25 |
ENST00000587097.1
|
ataxin 7-like 3 |
|
| chr17_-_42276574 Show fit | 4.04 |
ENST00000589805.1
|
ataxin 7-like 3 |
|
| chr17_-_58469591 Show fit | 3.43 |
ENST00000589335.1
|
ubiquitin specific peptidase 32 |
|
| chr4_+_156588350 Show fit | 3.26 |
ENST00000296518.7
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588806 Show fit | 3.13 |
ENST00000513574.1
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156587979 Show fit | 3.08 |
ENST00000511507.1
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588249 Show fit | 2.99 |
ENST00000393832.3
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588115 Show fit | 2.99 |
ENST00000455639.2
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_-_16900410 Show fit | 2.46 |
ENST00000304523.5
|
LIM domain binding 2 |
|
| chr9_-_14313641 Show fit | 2.45 |
ENST00000380953.1
|
nuclear factor I/B |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 17.0 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.4 | 10.7 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.3 | 8.2 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.7 | 5.1 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.1 | 3.2 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.1 | 3.2 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.2 | 2.9 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.9 | 2.7 | GO:0061216 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.2 | 2.5 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.1 | 2.5 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 13.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.7 | 11.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.3 | 5.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 3.7 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 3.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 3.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.4 | 3.2 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 3.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 3.1 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 13.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 11.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.7 | 8.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.5 | 4.8 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.0 | 3.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 3.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 3.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.3 | 3.0 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.2 | 2.8 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 4.3 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.1 | 4.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 4.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 3.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.2 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 1.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.2 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.2 | 5.2 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 3.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 2.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 2.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 2.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 2.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 1.9 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.1 | 1.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |