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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for E2F7_E2F1
Z-value: 1.03
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.29 | 1.5e-01 | Click! |
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.22 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_76183111 Show fit | 1.30 |
ENST00000405273.1
ENST00000590862.1 ENST00000590430.1 ENST00000586613.1 |
thymidine kinase 1, soluble |
|
| chr5_+_126112794 Show fit | 1.18 |
ENST00000261366.5
ENST00000395354.1 |
lamin B1 |
|
| chr11_-_19262486 Show fit | 1.16 |
ENST00000250024.4
|
E2F transcription factor 8 |
|
| chr8_-_95907423 Show fit | 1.08 |
ENST00000396133.3
ENST00000308108.4 |
cyclin E2 |
|
| chr5_+_68485433 Show fit | 0.97 |
ENST00000502689.1
|
centromere protein H |
|
| chr2_+_10262857 Show fit | 0.93 |
ENST00000304567.5
|
ribonucleotide reductase M2 |
|
| chr8_+_48873453 Show fit | 0.90 |
ENST00000523944.1
|
minichromosome maintenance complex component 4 |
|
| chr8_+_48873479 Show fit | 0.89 |
ENST00000262105.2
|
minichromosome maintenance complex component 4 |
|
| chr6_-_143266297 Show fit | 0.88 |
ENST00000367603.2
|
human immunodeficiency virus type I enhancer binding protein 2 |
|
| chr7_-_158497431 Show fit | 0.86 |
ENST00000449727.2
ENST00000409339.3 ENST00000409423.1 ENST00000356309.3 |
non-SMC condensin II complex, subunit G2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 3.3 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.3 | 3.1 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 2.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.8 | 2.5 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.0 | 2.3 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.2 | 2.0 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.4 | 1.5 | GO:0019087 | transformation of host cell by virus(GO:0019087) |
| 0.1 | 1.5 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.0 | 1.5 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.3 | 3.2 | GO:0000796 | condensin complex(GO:0000796) |
| 0.5 | 2.5 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.0 | 2.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.2 | 2.0 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 1.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.1 | 1.6 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 1.5 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 1.4 | GO:0005638 | lamin filament(GO:0005638) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.5 | 2.5 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 2.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 1.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 1.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 1.8 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.2 | 1.6 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 1.4 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 1.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.4 | 1.3 | GO:0004797 | thymidine kinase activity(GO:0004797) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 2.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 1.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.0 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 4.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 3.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 2.1 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 1.5 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.0 | 1.4 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 1.3 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 1.3 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 1.2 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |