Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for E2F8
Z-value: 0.86
Motif logo
Transcription factors associated with E2F8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F8 | hg19_v2_chr11_-_19263145_19263176 | 0.65 | 4.2e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_131762105 Show fit | 2.88 |
ENST00000368648.3
ENST00000355311.5 |
early B-cell factor 3 |
|
| chr9_-_74675521 Show fit | 2.34 |
ENST00000377024.3
|
chromosome 9 open reading frame 57 |
|
| chr18_+_72922710 Show fit | 2.26 |
ENST00000322038.5
|
teashirt zinc finger homeobox 1 |
|
| chr7_-_21985489 Show fit | 1.43 |
ENST00000356195.5
ENST00000447180.1 ENST00000373934.4 ENST00000457951.1 |
cell division cycle associated 7-like |
|
| chr7_-_21985656 Show fit | 1.41 |
ENST00000406877.3
|
cell division cycle associated 7-like |
|
| chr2_+_24346324 Show fit | 1.38 |
ENST00000407625.1
ENST00000420135.2 |
family with sequence similarity 228, member B |
|
| chr18_+_59992527 Show fit | 1.22 |
ENST00000586569.1
|
tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
|
| chr14_-_74551096 Show fit | 1.13 |
ENST00000350259.4
|
aldehyde dehydrogenase 6 family, member A1 |
|
| chr8_-_81083731 Show fit | 1.08 |
ENST00000379096.5
|
tumor protein D52 |
|
| chr22_+_35796056 Show fit | 1.04 |
ENST00000216122.4
|
minichromosome maintenance complex component 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.3 | GO:0060023 | soft palate development(GO:0060023) |
| 0.2 | 2.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.7 | 2.0 | GO:0100009 | circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009) |
| 0.5 | 1.9 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 0.1 | 1.9 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.0 | 1.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.6 | 1.7 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.3 | 1.6 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.1 | 1.6 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 1.6 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 3.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 1.6 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 1.6 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.3 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 1.1 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 1.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 1.0 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.0 | 1.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.3 | 0.9 | GO:0005656 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 3.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 2.0 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.3 | 1.9 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.1 | 1.9 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 1.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 1.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.6 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 1.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 1.4 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 0.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.5 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 1.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.3 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 1.2 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 1.1 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |