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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for E4F1

Z-value: 0.39

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Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
E4F1
ENSG00000167967.11 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273558_22736370.331.0e-01Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32812568 2.12 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_29595779 2.05 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr19_+_45504688 1.65 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr6_-_32812420 0.98 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr5_-_95297534 0.59 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr20_+_58179582 0.52 ENST00000371015.1
ENST00000395639.4
PHACTR3
phosphatase and actin regulator 3
chr17_-_36831156 0.51 ENST00000325814.5
C17orf96
chromosome 17 open reading frame 96
chr5_-_95297678 0.49 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr6_-_34664612 0.48 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr3_-_107941209 0.45 ENST00000492106.1
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chrX_-_83757399 0.43 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr6_+_64282447 0.42 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_16482554 0.41 ENST00000358432.5
EPHA2
EPH receptor A2
chr19_+_1941117 0.41 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chr18_+_23806437 0.40 ENST00000578121.1
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr22_+_39101728 0.36 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr7_-_140624499 0.36 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr20_+_33292068 0.36 ENST00000374810.3
ENST00000374809.2
ENST00000451665.1
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr6_+_64281906 0.36 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr8_+_94929110 0.33 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr20_+_44420570 0.31 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr20_+_44420617 0.30 ENST00000449078.1
ENST00000456939.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr2_-_128145498 0.29 ENST00000409179.2
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr17_+_71161140 0.29 ENST00000357585.2
SSTR2
somatostatin receptor 2
chr1_+_39456895 0.28 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chrX_-_153237258 0.28 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr4_-_76598544 0.26 ENST00000515457.1
ENST00000357854.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr3_+_185304059 0.26 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr1_+_85527987 0.25 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chrX_-_153236819 0.25 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr15_-_41047421 0.25 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
RMDN3
regulator of microtubule dynamics 3
chr6_-_53213587 0.23 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5
ELOVL fatty acid elongase 5
chr14_-_23388338 0.22 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RBM23
RNA binding motif protein 23
chr8_+_94929168 0.22 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr1_+_9599540 0.21 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr3_+_38206975 0.21 ENST00000446845.1
ENST00000311806.3
OXSR1
oxidative stress responsive 1
chr8_+_94929077 0.21 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr22_+_18121562 0.20 ENST00000355028.3
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr6_+_26204825 0.20 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr12_+_111471828 0.20 ENST00000261726.6
CUX2
cut-like homeobox 2
chr12_-_93835665 0.20 ENST00000552442.1
ENST00000550657.1
UBE2N
ubiquitin-conjugating enzyme E2N
chr19_+_52693259 0.19 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr3_-_107941230 0.19 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr17_-_40540586 0.19 ENST00000264657.5
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr2_+_75185619 0.19 ENST00000483063.1
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr4_-_111558135 0.19 ENST00000394598.2
ENST00000394595.3
PITX2
paired-like homeodomain 2
chr20_+_33146510 0.18 ENST00000397709.1
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr12_-_93836028 0.18 ENST00000318066.2
UBE2N
ubiquitin-conjugating enzyme E2N
chr4_-_54930790 0.18 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr22_+_32340447 0.17 ENST00000248975.5
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr11_-_33183006 0.17 ENST00000524827.1
ENST00000323959.4
ENST00000431742.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr2_-_64881018 0.17 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr11_-_77185094 0.17 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr19_-_46088068 0.16 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr11_-_6633799 0.16 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr3_+_184053703 0.16 ENST00000450976.1
ENST00000418281.1
ENST00000340957.5
ENST00000433578.1
FAM131A
family with sequence similarity 131, member A
chr22_+_32340481 0.16 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr11_-_3818688 0.15 ENST00000355260.3
ENST00000397004.4
ENST00000397007.4
ENST00000532475.1
NUP98
nucleoporin 98kDa
chr2_-_62115659 0.15 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr16_-_3767506 0.15 ENST00000538171.1
TRAP1
TNF receptor-associated protein 1
chr16_-_3767551 0.15 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr20_+_34203794 0.14 ENST00000374273.3
SPAG4
sperm associated antigen 4
chr2_-_62115725 0.14 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr2_-_75426826 0.14 ENST00000305249.5
TACR1
tachykinin receptor 1
chr6_+_30029008 0.13 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
ZNRD1
zinc ribbon domain containing 1
chr6_-_163148780 0.13 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2
parkin RBR E3 ubiquitin protein ligase
chr11_-_67276100 0.13 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr19_+_45349432 0.13 ENST00000252485.4
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chrX_-_73834449 0.13 ENST00000332687.6
ENST00000349225.2
RLIM
ring finger protein, LIM domain interacting
chr17_+_685513 0.12 ENST00000304478.4
RNMTL1
RNA methyltransferase like 1
chr8_-_98290087 0.12 ENST00000322128.3
TSPYL5
TSPY-like 5
chr6_-_163148700 0.12 ENST00000366894.1
ENST00000338468.3
PARK2
parkin RBR E3 ubiquitin protein ligase
chr22_+_18121356 0.12 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr5_-_32444828 0.12 ENST00000265069.8
ZFR
zinc finger RNA binding protein
chr6_+_110299501 0.12 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr1_+_180199393 0.12 ENST00000263726.2
LHX4
LIM homeobox 4
chr11_-_33183048 0.11 ENST00000438862.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr6_+_47445467 0.11 ENST00000359314.5
CD2AP
CD2-associated protein
chr14_+_94492674 0.11 ENST00000203664.5
ENST00000553723.1
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr16_-_46782221 0.11 ENST00000394809.4
MYLK3
myosin light chain kinase 3
chr17_+_7476136 0.10 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr1_-_151254362 0.10 ENST00000447795.2
RP11-126K1.2
Uncharacterized protein
chr10_+_95256356 0.09 ENST00000371485.3
CEP55
centrosomal protein 55kDa
chr2_+_202899310 0.09 ENST00000286201.1
FZD7
frizzled family receptor 7
chr4_-_186456652 0.09 ENST00000284767.5
ENST00000284770.5
PDLIM3
PDZ and LIM domain 3
chr10_+_119000604 0.09 ENST00000298472.5
SLC18A2
solute carrier family 18 (vesicular monoamine transporter), member 2
chr3_+_185303962 0.09 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr17_-_80231300 0.09 ENST00000398519.5
ENST00000580446.1
CSNK1D
casein kinase 1, delta
chrX_+_152224766 0.09 ENST00000370265.4
ENST00000447306.1
PNMA3
paraneoplastic Ma antigen 3
chr20_-_62258394 0.08 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr10_+_64893039 0.08 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chrX_-_13835147 0.08 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr6_+_163148973 0.08 ENST00000366888.2
PACRG
PARK2 co-regulated
chr20_-_44420507 0.08 ENST00000243938.4
WFDC3
WAP four-disulfide core domain 3
chr4_-_186456766 0.08 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr16_+_27561449 0.07 ENST00000261588.4
KIAA0556
KIAA0556
chr5_+_133706865 0.07 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr11_+_66188475 0.07 ENST00000311034.2
NPAS4
neuronal PAS domain protein 4
chr10_-_50970382 0.06 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr10_-_50970322 0.06 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr10_-_119134918 0.06 ENST00000334464.5
PDZD8
PDZ domain containing 8
chr17_+_42385927 0.06 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUNDC3A
RUN domain containing 3A
chr17_+_35294075 0.06 ENST00000254457.5
LHX1
LIM homeobox 1
chr3_-_185655795 0.05 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr17_+_18087553 0.05 ENST00000399138.4
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr8_-_95274536 0.05 ENST00000297596.2
ENST00000396194.2
GEM
GTP binding protein overexpressed in skeletal muscle
chr17_-_685493 0.05 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
GLOD4
glyoxalase domain containing 4
chr4_+_75311019 0.04 ENST00000502307.1
AREG
amphiregulin
chr5_-_133706695 0.04 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
CDKL3
cyclin-dependent kinase-like 3
chr8_-_116680833 0.04 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr1_+_151682909 0.04 ENST00000326413.3
ENST00000442233.2
RIIAD1
AL589765.1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr1_+_110527308 0.04 ENST00000369799.5
AHCYL1
adenosylhomocysteinase-like 1
chr16_+_29911864 0.04 ENST00000308748.5
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr1_+_26496362 0.04 ENST00000374266.5
ENST00000270812.5
ZNF593
zinc finger protein 593
chr4_-_76598326 0.03 ENST00000503660.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr17_-_40540484 0.03 ENST00000588969.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr1_+_8378140 0.03 ENST00000377479.2
SLC45A1
solute carrier family 45, member 1
chr17_-_685559 0.03 ENST00000301329.6
GLOD4
glyoxalase domain containing 4
chr2_+_220408724 0.03 ENST00000421791.1
ENST00000373883.3
ENST00000451952.1
TMEM198
transmembrane protein 198
chr7_-_137686791 0.03 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chr17_-_40540377 0.02 ENST00000404395.3
ENST00000389272.3
ENST00000585517.1
ENST00000588065.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr1_-_70820357 0.02 ENST00000370944.4
ENST00000262346.6
ANKRD13C
ankyrin repeat domain 13C
chr1_+_70820451 0.01 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HHLA3
HERV-H LTR-associating 3
chr5_+_68513557 0.01 ENST00000256441.4
MRPS36
mitochondrial ribosomal protein S36
chr17_+_39845134 0.01 ENST00000591776.1
ENST00000469257.1
EIF1
eukaryotic translation initiation factor 1
chr5_-_132948216 0.01 ENST00000265342.7
FSTL4
follistatin-like 4
chr3_-_101395936 0.01 ENST00000461821.1
ZBTB11
zinc finger and BTB domain containing 11
chr19_-_59066452 0.00 ENST00000312547.2
CHMP2A
charged multivesicular body protein 2A
chr4_+_1873100 0.00 ENST00000508803.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr19_-_59066327 0.00 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1901491 axial mesoderm formation(GO:0048320) negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.5 GO:0019046 release from viral latency(GO:0019046)
0.1 1.6 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.3 GO:0009386 translational attenuation(GO:0009386)
0.1 0.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.2 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1 0.2 GO:0060127 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) superior vena cava morphogenesis(GO:0060578)
0.1 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.1 0.3 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.2 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 2.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.0 0.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 3.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.1 GO:0035106 angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.2 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390) respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.4 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.0 0.6 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.2 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.3 GO:0007614 short-term memory(GO:0007614)
0.0 0.0 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.3 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.0 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.0 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.6 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 3.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.4 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.2 GO:0097447 dendritic tree(GO:0097447)
0.0 0.6 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 1.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0044754 autolysosome(GO:0044754)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.1 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.8 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 3.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.3 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.5 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.0 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
0.0 0.0 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 3.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs