Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for EBF3
Z-value: 0.61
Motif logo
Transcription factors associated with EBF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF3 | hg19_v2_chr10_-_131762105_131762105 | 0.38 | 5.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_172198190 Show fit | 0.83 |
ENST00000239223.3
|
dual specificity phosphatase 1 |
|
| chr2_+_48757278 Show fit | 0.69 |
ENST00000404752.1
ENST00000406226.1 |
stonin 1 |
|
| chr19_+_2476116 Show fit | 0.64 |
ENST00000215631.4
ENST00000587345.1 |
growth arrest and DNA-damage-inducible, beta |
|
| chr1_+_32084794 Show fit | 0.63 |
ENST00000373705.1
|
hypocretin (orexin) receptor 1 |
|
| chr8_-_19459993 Show fit | 0.59 |
ENST00000454498.2
ENST00000520003.1 |
chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
|
| chr12_+_53443680 Show fit | 0.58 |
ENST00000314250.6
ENST00000451358.1 |
tensin like C1 domain containing phosphatase (tensin 2) |
|
| chr12_+_53443963 Show fit | 0.58 |
ENST00000546602.1
ENST00000552570.1 ENST00000549700.1 |
tensin like C1 domain containing phosphatase (tensin 2) |
|
| chr18_-_72920372 Show fit | 0.53 |
ENST00000581620.1
ENST00000582437.1 |
zinc binding alcohol dehydrogenase domain containing 2 |
|
| chr9_-_134151915 Show fit | 0.47 |
ENST00000372271.3
|
family with sequence similarity 78, member A |
|
| chr11_+_64058820 Show fit | 0.45 |
ENST00000422670.2
|
potassium channel, subfamily K, member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0071469 | cellular response to alkaline pH(GO:0071469) |
| 0.1 | 1.0 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.2 | 0.8 | GO:0051585 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.1 | 0.8 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.0 | 0.7 | GO:0060272 | mesodermal cell fate specification(GO:0007501) embryonic skeletal joint morphogenesis(GO:0060272) |
| 0.0 | 0.7 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 0.7 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.0 | 0.7 | GO:0006692 | prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693) |
| 0.2 | 0.6 | GO:0045608 | negative regulation of auditory receptor cell differentiation(GO:0045608) |
| 0.1 | 0.6 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.7 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.6 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.5 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.4 | GO:0035838 | growing cell tip(GO:0035838) |
| 0.1 | 0.4 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.0 | 0.4 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.4 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.1 | 0.3 | GO:1990742 | microvesicle(GO:1990742) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0098782 | mechanically-gated potassium channel activity(GO:0098782) |
| 0.3 | 0.8 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.2 | 0.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.0 | 0.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.7 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
| 0.2 | 0.6 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.2 | 0.6 | GO:0016499 | orexin receptor activity(GO:0016499) |
| 0.2 | 0.5 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.0 | 0.5 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.1 | 0.4 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.8 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 0.7 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 0.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.4 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.3 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |