Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for EGR1_EGR4
Z-value: 0.99
Motif logo
Transcription factors associated with EGR1_EGR4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR4 | hg19_v2_chr2_-_73520667_73520833 | -0.32 | 1.2e-01 | Click! |
| EGR1 | hg19_v2_chr5_+_137801160_137801179 | -0.23 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_65886244 Show fit | 3.25 |
ENST00000344610.8
|
leptin receptor |
|
| chr2_-_128145498 Show fit | 2.69 |
ENST00000409179.2
|
mitogen-activated protein kinase kinase kinase 2 |
|
| chr2_+_191513789 Show fit | 1.79 |
ENST00000409581.1
|
NGFI-A binding protein 1 (EGR1 binding protein 1) |
|
| chr13_-_41635512 Show fit | 1.75 |
ENST00000405737.2
|
E74-like factor 1 (ets domain transcription factor) |
|
| chr6_+_37137939 Show fit | 1.70 |
ENST00000373509.5
|
pim-1 oncogene |
|
| chr1_+_65886326 Show fit | 1.51 |
ENST00000371059.3
ENST00000371060.3 ENST00000349533.6 ENST00000406510.3 |
leptin receptor |
|
| chr17_+_57408994 Show fit | 1.45 |
ENST00000312655.4
|
yippee-like 2 (Drosophila) |
|
| chr19_+_676385 Show fit | 1.43 |
ENST00000166139.4
|
follistatin-like 3 (secreted glycoprotein) |
|
| chr4_+_156587853 Show fit | 1.37 |
ENST00000506455.1
ENST00000511108.1 |
guanylate cyclase 1, soluble, alpha 3 |
|
| chr2_+_42396574 Show fit | 1.36 |
ENST00000401738.3
|
echinoderm microtubule associated protein like 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR1_EGR4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.8 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 0.1 | 4.0 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.0 | 2.3 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
| 0.7 | 2.1 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.0 | 2.0 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.6 | 1.8 | GO:0034226 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 0.6 | 1.8 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.0 | 1.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 1.8 | GO:0071427 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.2 | 1.6 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.2 | 1.9 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 1.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 1.1 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 1.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 1.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 1.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 2.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 2.4 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 2.0 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.5 | 1.8 | GO:0005287 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.1 | 1.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 1.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 1.4 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 1.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 1.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 4.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 3.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 3.3 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 3.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 2.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 3.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.5 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 2.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.9 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 1.8 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 1.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 1.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |