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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ELF2_GABPA_ELF5
Z-value: 1.76
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Transcription factors associated with ELF2_GABPA_ELF5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000109381.15 | E74 like ETS transcription factor 2 | |
| ENSG00000154727.6 | GA binding protein transcription factor subunit alpha | |
| ENSG00000135374.5 | E74 like ETS transcription factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GABPA | hg19_v2_chr21_+_27107672_27107698 | -0.36 | 8.0e-02 | Click! |
| ELF5 | hg19_v2_chr11_-_34535297_34535317 | 0.29 | 1.7e-01 | Click! |
| ELF2 | hg19_v2_chr4_-_140098339_140098392, hg19_v2_chr4_-_140005341_140005411 | -0.21 | 3.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 29.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 26.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.3 | 11.8 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.3 | 11.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 10.8 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.2 | 10.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.3 | 10.0 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 1.2 | 9.7 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.3 | 8.1 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.3 | 7.9 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 17.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 16.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.8 | 16.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 14.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 14.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 12.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 12.3 | GO:0044452 | nucleolar part(GO:0044452) |
| 0.1 | 11.5 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 8.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 63.2 | GO:0003676 | nucleic acid binding(GO:0003676) |
| 2.0 | 21.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.7 | 21.5 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 13.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 13.0 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.2 | 9.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 7.7 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.3 | 7.2 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.4 | 7.1 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 7.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 9.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 8.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 7.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 6.5 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 6.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 6.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 6.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 5.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 27.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 25.0 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.3 | 11.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.3 | 9.4 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 8.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 7.9 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.3 | 7.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 6.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 6.2 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |