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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ELK4_ETV5_ELK1_ELK3_ELF4
Z-value: 1.65
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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000158711.9 | ETS transcription factor ELK4 | |
| ENSG00000244405.3 | ETS variant transcription factor 5 | |
| ENSG00000126767.13 | ETS transcription factor ELK1 | |
| ENSG00000111145.3 | ETS transcription factor ELK3 | |
| ENSG00000102034.12 | E74 like ETS transcription factor 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELK3 | hg19_v2_chr12_+_96588279_96588323 | -0.36 | 7.8e-02 | Click! |
| ETV5 | hg19_v2_chr3_-_185826286_185826464 | 0.31 | 1.3e-01 | Click! |
| ELK1 | hg19_v2_chrX_-_47509887_47509990 | -0.27 | 1.8e-01 | Click! |
| ELF4 | hg19_v2_chrX_-_129244655_129244697, hg19_v2_chrX_-_129244454_129244488 | -0.10 | 6.5e-01 | Click! |
| ELK4 | hg19_v2_chr1_-_205601064_205601090 | -0.06 | 7.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 14.9 | GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition(GO:0051437) |
| 0.3 | 13.5 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.5 | 10.2 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 9.0 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.2 | 7.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 6.6 | GO:0033108 | mitochondrial respiratory chain complex assembly(GO:0033108) |
| 0.2 | 6.4 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 5.7 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 5.5 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 65.2 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 35.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 13.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.4 | 13.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 10.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 8.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 8.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 8.0 | GO:0005814 | centriole(GO:0005814) |
| 0.9 | 7.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 6.6 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 109.4 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 40.7 | GO:0003676 | nucleic acid binding(GO:0003676) |
| 0.1 | 12.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 11.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 7.5 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.1 | 6.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 6.0 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.5 | 5.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 4.9 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896) |
| 0.1 | 4.9 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 7.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 5.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 5.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.1 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 2.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.9 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 59.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 18.3 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.3 | 11.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.2 | 8.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.3 | 7.7 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.1 | 7.3 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 6.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 5.8 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.1 | 5.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 5.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |