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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for EMX2
Z-value: 1.01
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Transcription factors associated with EMX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EMX2 | hg19_v2_chr10_+_119301928_119301955 | 0.28 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_41540160 Show fit | 4.79 |
ENST00000503057.1
ENST00000511496.1 |
LIM and calponin homology domains 1 |
|
| chr4_-_101439242 Show fit | 4.20 |
ENST00000296420.4
|
endomucin |
|
| chr1_+_84609944 Show fit | 3.97 |
ENST00000370685.3
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr6_-_76072719 Show fit | 3.40 |
ENST00000370020.1
|
filamin A interacting protein 1 |
|
| chr4_-_101439148 Show fit | 3.26 |
ENST00000511970.1
ENST00000502569.1 ENST00000305864.3 |
endomucin |
|
| chr2_-_99279928 Show fit | 2.79 |
ENST00000414521.2
|
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A |
|
| chr9_-_47314222 Show fit | 2.73 |
ENST00000420228.1
ENST00000438517.1 ENST00000414020.1 |
AL953854.2 |
|
| chr5_-_111093167 Show fit | 2.73 |
ENST00000446294.2
ENST00000419114.2 |
neuronal regeneration related protein |
|
| chr11_-_63376013 Show fit | 2.63 |
ENST00000540943.1
|
phospholipase A2, group XVI |
|
| chr4_-_186877806 Show fit | 2.61 |
ENST00000355634.5
|
sorbin and SH3 domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EMX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.6 | 4.0 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 2.8 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.3 | 2.6 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.1 | 2.6 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 2.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.3 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.7 | 2.2 | GO:0014839 | myoblast migration involved in skeletal muscle regeneration(GO:0014839) |
| 0.2 | 2.2 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.3 | 2.1 | GO:0006848 | pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 4.8 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.2 | 4.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 3.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 2.2 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 2.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.7 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 1.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 1.5 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 4.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.5 | 2.6 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
| 0.0 | 2.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 2.3 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.3 | 2.2 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.5 | 2.1 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.3 | 2.0 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 1.9 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 1.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.6 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.6 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 2.4 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 2.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 2.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 2.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.1 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.1 | 2.0 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 1.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 1.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |