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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for EN1_ESX1_GBX1

Z-value: 0.70

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Transcription factors associated with EN1_ESX1_GBX1

Gene Symbol Gene ID Gene Info
EN1
ENSG00000163064.6 engrailed homeobox 1
ESX1
ENSG00000123576.5 ESX homeobox 1
GBX1
ENSG00000164900.4 gastrulation brain homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EN1hg19_v2_chr2_-_119605253_1196052640.471.9e-02Click!
ESX1hg19_v2_chrX_-_103499602_1034996170.232.6e-01Click!
GBX1hg19_v2_chr7_-_150864635_1508647850.096.6e-01Click!

Activity profile of EN1_ESX1_GBX1 motif

Sorted Z-values of EN1_ESX1_GBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_71959159 3.29 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
CYB5A
cytochrome b5 type A (microsomal)
chr7_-_92777606 2.64 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr6_+_127898312 2.59 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr10_-_49813090 2.26 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr1_+_244515930 2.05 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr11_-_117747434 2.02 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr6_+_153552455 1.95 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr11_-_117748138 1.94 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr4_+_169013666 1.93 ENST00000359299.3
ANXA10
annexin A10
chr11_-_117747607 1.92 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr7_-_25019760 1.88 ENST00000352860.1
ENST00000353930.1
ENST00000431825.2
ENST00000313367.2
OSBPL3
oxysterol binding protein-like 3
chr3_+_130569429 1.70 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr18_+_32173276 1.51 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr3_+_173116225 1.50 ENST00000457714.1
NLGN1
neuroligin 1
chr2_+_152214098 1.44 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_-_123339343 1.44 ENST00000578202.1
MYLK
myosin light chain kinase
chr10_-_49860525 1.26 ENST00000435790.2
ARHGAP22
Rho GTPase activating protein 22
chr7_+_138145076 1.20 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr5_+_125758865 1.15 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr5_+_125758813 1.11 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr18_-_33709268 1.09 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr8_-_90996459 1.07 ENST00000517337.1
ENST00000409330.1
NBN
nibrin
chr2_+_65216462 1.07 ENST00000234256.3
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr15_-_55562479 1.06 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr22_+_18632666 1.05 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr10_+_111765562 1.04 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr6_+_26365443 1.04 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr4_-_39979576 1.03 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr3_-_123339418 1.03 ENST00000583087.1
MYLK
myosin light chain kinase
chr2_-_136678123 1.02 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr3_+_111717600 1.02 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111717511 1.00 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr17_+_79650962 0.96 ENST00000329138.4
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr3_+_111718036 0.96 ENST00000455401.2
TAGLN3
transgelin 3
chr5_+_52776228 0.96 ENST00000256759.3
FST
follistatin
chr8_-_10512569 0.96 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr1_+_68150744 0.94 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr14_-_95236551 0.94 ENST00000238558.3
GSC
goosecoid homeobox
chr5_-_150473127 0.94 ENST00000521001.1
TNIP1
TNFAIP3 interacting protein 1
chr15_-_55563072 0.92 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr19_-_6737576 0.91 ENST00000601716.1
ENST00000264080.7
GPR108
G protein-coupled receptor 108
chr5_-_13944652 0.91 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr12_-_16759711 0.91 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_105416039 0.90 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr15_-_55562582 0.90 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr8_+_50824233 0.86 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr11_+_33061543 0.85 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr11_-_118023490 0.82 ENST00000324727.4
SCN4B
sodium channel, voltage-gated, type IV, beta subunit
chr1_-_173174681 0.82 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr2_-_145277569 0.82 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr20_+_18488137 0.79 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chr1_+_160160283 0.78 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr17_-_38911580 0.78 ENST00000312150.4
KRT25
keratin 25
chr18_+_55888767 0.77 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr12_-_56694142 0.75 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
CS
citrate synthase
chr3_+_133292759 0.74 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr1_+_160160346 0.74 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr11_+_24518723 0.72 ENST00000336930.6
ENST00000529015.1
ENST00000533227.1
LUZP2
leucine zipper protein 2
chr11_+_75526212 0.71 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr5_-_160279207 0.71 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr5_+_31193847 0.70 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr17_+_42785976 0.70 ENST00000393547.2
ENST00000398338.3
DBF4B
DBF4 homolog B (S. cerevisiae)
chr5_+_52776449 0.70 ENST00000396947.3
FST
follistatin
chr12_+_26348246 0.69 ENST00000422622.2
SSPN
sarcospan
chr3_-_157221380 0.69 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr1_-_36916066 0.68 ENST00000315643.9
OSCP1
organic solute carrier partner 1
chr2_+_196313239 0.67 ENST00000413290.1
AC064834.1
AC064834.1
chr9_-_16728161 0.65 ENST00000603713.1
ENST00000603313.1
BNC2
basonuclin 2
chr1_-_36916011 0.65 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
OSCP1
organic solute carrier partner 1
chr6_-_100912785 0.65 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr1_-_2461684 0.64 ENST00000378453.3
HES5
hes family bHLH transcription factor 5
chr16_+_69345243 0.64 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr19_-_6737241 0.64 ENST00000430424.4
ENST00000597298.1
GPR108
G protein-coupled receptor 108
chr19_+_48949030 0.64 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr4_-_76928641 0.64 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr12_-_51422017 0.63 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr2_+_143635067 0.62 ENST00000264170.4
KYNU
kynureninase
chr18_+_57567180 0.61 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr2_-_208031943 0.61 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr15_-_42264702 0.60 ENST00000220325.4
EHD4
EH-domain containing 4
chr17_-_30228678 0.60 ENST00000261708.4
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr2_+_210636697 0.59 ENST00000439458.1
ENST00000272845.6
UNC80
unc-80 homolog (C. elegans)
chr7_-_27169801 0.58 ENST00000511914.1
HOXA4
homeobox A4
chr8_-_87755878 0.58 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr14_+_32798462 0.57 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr10_+_96522361 0.57 ENST00000371321.3
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr1_+_40713573 0.56 ENST00000372766.3
TMCO2
transmembrane and coiled-coil domains 2
chr20_+_31805131 0.56 ENST00000375454.3
ENST00000375452.3
BPIFA3
BPI fold containing family A, member 3
chr1_+_209878182 0.56 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_+_34204642 0.55 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr14_-_24616426 0.55 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_+_47448102 0.54 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr17_-_64225508 0.54 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr9_+_139780942 0.54 ENST00000247668.2
ENST00000359662.3
TRAF2
TNF receptor-associated factor 2
chr15_+_89164520 0.53 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr17_-_40337470 0.53 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr11_+_57435219 0.52 ENST00000527985.1
ENST00000287169.3
ZDHHC5
zinc finger, DHHC-type containing 5
chrX_-_106243451 0.51 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr4_-_119759795 0.51 ENST00000419654.2
SEC24D
SEC24 family member D
chr20_+_43538692 0.50 ENST00000217074.4
ENST00000255136.3
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr1_+_175036966 0.49 ENST00000239462.4
TNN
tenascin N
chr17_-_39306054 0.49 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr1_+_156163880 0.49 ENST00000359511.4
ENST00000423538.2
SLC25A44
solute carrier family 25, member 44
chr8_+_32579341 0.49 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr7_-_73038867 0.48 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr20_+_43538756 0.48 ENST00000537323.1
ENST00000217073.2
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr20_+_18447771 0.48 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr4_-_122085469 0.47 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr7_-_73038822 0.47 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chrX_-_77225135 0.47 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr11_-_40315640 0.46 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr2_-_208989225 0.46 ENST00000264376.4
CRYGD
crystallin, gamma D
chr11_+_67219867 0.46 ENST00000438189.2
CABP4
calcium binding protein 4
chr14_+_74034310 0.46 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr3_-_167191814 0.46 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr18_-_33702078 0.45 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr17_-_39324424 0.44 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr19_-_7968427 0.44 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr2_-_10587897 0.44 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr12_-_28123206 0.44 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr5_-_20575959 0.43 ENST00000507958.1
CDH18
cadherin 18, type 2
chr1_-_27998689 0.43 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr15_+_76629064 0.43 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr9_+_80912059 0.43 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr4_-_89205705 0.43 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr12_-_28122980 0.42 ENST00000395868.3
ENST00000534890.1
PTHLH
parathyroid hormone-like hormone
chrX_-_13835147 0.42 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr3_+_121774202 0.42 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr5_+_66300446 0.42 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_-_88974236 0.42 ENST00000228280.5
ENST00000552044.1
ENST00000357116.4
KITLG
KIT ligand
chr8_-_12612962 0.41 ENST00000398246.3
LONRF1
LON peptidase N-terminal domain and ring finger 1
chr20_-_18447667 0.41 ENST00000262547.5
ENST00000329494.5
ENST00000357236.4
DZANK1
double zinc ribbon and ankyrin repeat domains 1
chr1_-_205325850 0.41 ENST00000537168.1
KLHDC8A
kelch domain containing 8A
chr4_-_8873531 0.40 ENST00000400677.3
HMX1
H6 family homeobox 1
chr19_-_46088068 0.40 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr12_+_26348429 0.40 ENST00000242729.2
SSPN
sarcospan
chr10_+_24497704 0.39 ENST00000376456.4
ENST00000458595.1
KIAA1217
KIAA1217
chr15_+_54305101 0.39 ENST00000260323.11
ENST00000545554.1
ENST00000537900.1
UNC13C
unc-13 homolog C (C. elegans)
chr14_+_24616588 0.39 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr5_+_140529630 0.39 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr4_-_116034979 0.39 ENST00000264363.2
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr8_-_90996837 0.39 ENST00000519426.1
ENST00000265433.3
NBN
nibrin
chr1_-_152386732 0.39 ENST00000271835.3
CRNN
cornulin
chr1_+_101003687 0.38 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr7_-_25268104 0.38 ENST00000222674.2
NPVF
neuropeptide VF precursor
chrX_-_110655306 0.38 ENST00000371993.2
DCX
doublecortin
chr19_+_39421556 0.38 ENST00000407800.2
ENST00000402029.3
MRPS12
mitochondrial ribosomal protein S12
chr11_-_117747327 0.38 ENST00000584230.1
ENST00000527429.1
ENST00000584394.1
ENST00000532984.1
FXYD6
FXYD6-FXYD2
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr5_-_35938674 0.36 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chr15_+_75080883 0.36 ENST00000567571.1
CSK
c-src tyrosine kinase
chr7_+_129984630 0.36 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
CPA5
carboxypeptidase A5
chr4_+_89206076 0.36 ENST00000500009.2
RP11-10L7.1
RP11-10L7.1
chr5_+_81601166 0.36 ENST00000439350.1
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr12_+_53662110 0.35 ENST00000552462.1
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr5_-_95297678 0.35 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr19_+_45394477 0.34 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr6_-_89927151 0.34 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr15_+_94899183 0.34 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr1_+_160370344 0.34 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr6_-_87804815 0.34 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr4_-_69536346 0.34 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr8_-_20040601 0.33 ENST00000265808.7
ENST00000522513.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr12_+_107712173 0.33 ENST00000280758.5
ENST00000420571.2
BTBD11
BTB (POZ) domain containing 11
chr8_-_20040638 0.33 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr3_+_152879985 0.33 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chrX_+_38211777 0.33 ENST00000039007.4
OTC
ornithine carbamoyltransferase
chr5_-_24645078 0.33 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr6_+_135502501 0.33 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr2_-_224467093 0.33 ENST00000305409.2
SCG2
secretogranin II
chr18_+_59000815 0.32 ENST00000262717.4
CDH20
cadherin 20, type 2
chr10_+_74451883 0.32 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr4_-_57547454 0.32 ENST00000556376.2
HOPX
HOP homeobox
chr9_-_5339873 0.32 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr10_-_24770632 0.32 ENST00000596413.1
AL353583.1
AL353583.1
chr21_-_32253874 0.32 ENST00000332378.4
KRTAP11-1
keratin associated protein 11-1
chr14_-_75389975 0.32 ENST00000555647.1
ENST00000557413.1
RPS6KL1
ribosomal protein S6 kinase-like 1
chr18_+_32556892 0.32 ENST00000591734.1
ENST00000413393.1
ENST00000589180.1
ENST00000587359.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_+_42786051 0.32 ENST00000315005.3
DBF4B
DBF4 homolog B (S. cerevisiae)
chr5_-_132200477 0.31 ENST00000296875.2
GDF9
growth differentiation factor 9
chr4_-_143226979 0.31 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_-_57547870 0.31 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr3_+_130569592 0.31 ENST00000533801.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr5_-_10761206 0.31 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chrX_-_130423200 0.31 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr5_-_159827033 0.31 ENST00000523213.1
C5orf54
chromosome 5 open reading frame 54
chr2_+_158114051 0.30 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr12_+_53662073 0.30 ENST00000553219.1
ENST00000257934.4
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr10_-_92681033 0.30 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_-_39203519 0.30 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr12_-_16761007 0.30 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_29236269 0.30 ENST00000313071.4
FOXG1
forkhead box G1
chr1_-_101360331 0.30 ENST00000416479.1
ENST00000370113.3
EXTL2
exostosin-like glycosyltransferase 2
chr5_-_95297534 0.30 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr21_-_15918618 0.30 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_-_139613269 0.29 ENST00000358430.3
TXLNB
taxilin beta
chr15_+_41913690 0.29 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr6_-_62996066 0.29 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr2_-_89513402 0.29 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr7_-_2883928 0.29 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr12_+_72058130 0.29 ENST00000547843.1
THAP2
THAP domain containing, apoptosis associated protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of EN1_ESX1_GBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0099545 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.5 2.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.4 1.5 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.3 1.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.3 2.0 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.3 0.9 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.3 3.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.3 0.8 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.2 0.9 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.2 0.6 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.2 1.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 1.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.2 0.6 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2 1.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 1.1 GO:0015808 L-alanine transport(GO:0015808) L-cystine transport(GO:0015811)
0.2 1.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 1.6 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 3.3 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.2 0.8 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 0.9 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.4 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.4 GO:0045404 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.4 GO:0070666 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 0.8 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.5 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.1 0.5 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 0.6 GO:0015692 lead ion transport(GO:0015692)
0.1 0.4 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.7 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.7 GO:1902261 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.7 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.6 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.3 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.1 0.3 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.4 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 0.4 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.3 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.1 0.6 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 1.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.5 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 1.0 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 7.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 0.1 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 0.5 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 0.6 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.1 0.9 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 0.2 GO:0003162 atrioventricular node development(GO:0003162)
0.1 0.4 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 0.5 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.3 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.6 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.2 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.2 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.3 GO:0043455 regulation of secondary metabolic process(GO:0043455)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 1.0 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.5 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.4 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.2 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.1 0.9 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.4 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.5 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.2 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 1.0 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
0.0 0.9 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.2 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.9 GO:0036158 lateral ventricle development(GO:0021670) outer dynein arm assembly(GO:0036158)
0.0 0.4 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 1.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.9 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.4 GO:1904180 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.0 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.2 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.0 0.2 GO:0048241 epinephrine transport(GO:0048241)
0.0 0.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:1900222 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.3 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 1.5 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.3 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.8 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.2 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:1990523 bone regeneration(GO:1990523)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.7 GO:0030728 ovulation(GO:0030728)
0.0 0.9 GO:0002076 osteoblast development(GO:0002076)
0.0 1.0 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.0 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.4 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 1.4 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.7 GO:0043586 tongue development(GO:0043586)
0.0 0.1 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.3 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.6 GO:0006907 pinocytosis(GO:0006907)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241) detection of muscle stretch(GO:0035995)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.1 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.3 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.4 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.2 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.4 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 1.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.0 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0042693 muscle cell fate commitment(GO:0042693) positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.0 GO:0071839 apoptotic process in bone marrow(GO:0071839) regulation of cell proliferation in bone marrow(GO:0071863) positive regulation of cell proliferation in bone marrow(GO:0071864) regulation of apoptotic process in bone marrow(GO:0071865) negative regulation of apoptotic process in bone marrow(GO:0071866) positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 1.3 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 0.0 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.0 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.0 0.0 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.0 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.0 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.0 0.3 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0033565 ESCRT-0 complex(GO:0033565)
0.3 1.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 1.5 GO:0014802 terminal cisterna(GO:0014802)
0.2 0.5 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.2 1.5 GO:0030870 Mre11 complex(GO:0030870)
0.2 3.4 GO:0032433 filopodium tip(GO:0032433)
0.2 3.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.6 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.5 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.4 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.8 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.3 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.7 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.1 0.3 GO:1990246 uniplex complex(GO:1990246)
0.1 0.7 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.3 GO:0044305 calyx of Held(GO:0044305)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 1.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 2.3 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.8 GO:0005771 multivesicular body(GO:0005771)
0.0 1.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 2.0 GO:0042383 sarcolemma(GO:0042383)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 3.4 GO:0043209 myelin sheath(GO:0043209)
0.0 2.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0097433 dense body(GO:0097433)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.7 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 0.7 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.2 1.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.2 0.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 1.1 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) L-cystine transmembrane transporter activity(GO:0015184) alanine transmembrane transporter activity(GO:0022858)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.6 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 1.4 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 7.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 2.9 GO:0031489 myosin V binding(GO:0031489)
0.1 0.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 1.7 GO:0048185 activin binding(GO:0048185)
0.1 0.2 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 0.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.7 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.2 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.3 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.1 0.2 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.1 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.2 GO:0000994 RNA polymerase III core binding(GO:0000994)
0.1 0.3 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.3 GO:0015288 porin activity(GO:0015288)
0.0 0.3 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.5 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 1.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 2.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 1.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.3 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.6 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 1.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0001034 RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.7 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.2 GO:0098505 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.0 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.0 0.0 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.0 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.6 GO:0000149 SNARE binding(GO:0000149)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0015563 thiamine uptake transmembrane transporter activity(GO:0015403) uptake transmembrane transporter activity(GO:0015563)
0.0 0.3 GO:0070402 NADPH binding(GO:0070402)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 1.1 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.4 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.1 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.6 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 3.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.5 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 3.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors