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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for EN2_GBX2_LBX2

Z-value: 0.36

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
EN2
ENSG00000164778.4 engrailed homeobox 2
GBX2
ENSG00000168505.6 gastrulation brain homeobox 2
LBX2
ENSG00000179528.11 ladybird homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EN2hg19_v2_chr7_+_155250824_1552508240.106.3e-01Click!
GBX2hg19_v2_chr2_-_237076992_2370770120.058.1e-01Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_71959159 1.21 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
CYB5A
cytochrome b5 type A (microsomal)
chr5_-_95297534 0.73 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr15_-_55562479 0.72 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr5_+_125758865 0.68 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr5_+_125758813 0.68 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr15_-_55563072 0.67 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55562582 0.63 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr5_-_95297678 0.58 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr18_+_59000815 0.56 ENST00000262717.4
CDH20
cadherin 20, type 2
chr18_-_33709268 0.47 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr18_+_55888767 0.44 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr20_+_18488137 0.38 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chr1_-_118472171 0.36 ENST00000369442.3
GDAP2
ganglioside induced differentiation associated protein 2
chr7_-_92777606 0.36 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr3_+_130569429 0.33 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr3_+_133292759 0.30 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr7_-_122339162 0.30 ENST00000340112.2
RNF133
ring finger protein 133
chr8_-_10512569 0.28 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr14_-_51027838 0.28 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr18_+_32173276 0.27 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr11_-_40315640 0.26 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr1_+_101003687 0.26 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr6_+_135502501 0.25 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_+_111717511 0.24 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr3_+_111717600 0.24 ENST00000273368.4
TAGLN3
transgelin 3
chr4_-_39979576 0.24 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr4_-_105416039 0.24 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr1_+_160160283 0.23 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr17_-_39203519 0.22 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr1_+_160160346 0.22 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr17_-_38911580 0.22 ENST00000312150.4
KRT25
keratin 25
chr5_+_66300446 0.22 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_+_26199737 0.21 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr18_-_33702078 0.21 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr3_+_111718036 0.21 ENST00000455401.2
TAGLN3
transgelin 3
chrM_+_12331 0.21 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr5_-_35938674 0.20 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chrX_-_21676442 0.20 ENST00000379499.2
KLHL34
kelch-like family member 34
chr6_-_31107127 0.19 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr18_-_31803435 0.19 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4
nucleolar protein 4
chr11_+_75526212 0.19 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr3_+_115342349 0.19 ENST00000393780.3
GAP43
growth associated protein 43
chr17_+_59489112 0.18 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr12_-_56694142 0.18 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
CS
citrate synthase
chr19_+_7030589 0.16 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr3_-_195538728 0.15 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr11_+_57435219 0.14 ENST00000527985.1
ENST00000287169.3
ZDHHC5
zinc finger, DHHC-type containing 5
chr6_-_26199471 0.14 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr18_-_31803169 0.14 ENST00000590712.1
NOL4
nucleolar protein 4
chr12_-_89746173 0.14 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr3_+_111718173 0.14 ENST00000494932.1
TAGLN3
transgelin 3
chr8_+_50824233 0.13 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr17_-_39211463 0.13 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr19_+_51728316 0.13 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr3_+_173116225 0.13 ENST00000457714.1
NLGN1
neuroligin 1
chr2_+_65216462 0.12 ENST00000234256.3
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_+_171227069 0.12 ENST00000354841.4
FMO1
flavin containing monooxygenase 1
chr19_-_6737576 0.12 ENST00000601716.1
ENST00000264080.7
GPR108
G protein-coupled receptor 108
chrX_-_46187069 0.11 ENST00000446884.1
RP1-30G7.2
RP1-30G7.2
chr20_-_18447667 0.11 ENST00000262547.5
ENST00000329494.5
ENST00000357236.4
DZANK1
double zinc ribbon and ankyrin repeat domains 1
chr13_-_36788718 0.11 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr3_-_157221380 0.11 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr14_+_32798462 0.11 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr4_+_169013666 0.10 ENST00000359299.3
ANXA10
annexin A10
chr14_-_82000140 0.10 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr19_-_6737241 0.10 ENST00000430424.4
ENST00000597298.1
GPR108
G protein-coupled receptor 108
chr22_+_39916558 0.10 ENST00000337304.2
ENST00000396680.1
ATF4
activating transcription factor 4
chr10_-_50970322 0.10 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr15_+_89631381 0.10 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr15_+_89631647 0.10 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr10_-_50970382 0.10 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr2_-_61697862 0.10 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr21_-_32253874 0.09 ENST00000332378.4
KRTAP11-1
keratin associated protein 11-1
chr19_+_48949030 0.09 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr7_-_73038822 0.09 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr7_-_73038867 0.09 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr4_-_89205705 0.09 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr1_-_152386732 0.09 ENST00000271835.3
CRNN
cornulin
chr8_+_22424551 0.09 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr3_+_172468472 0.09 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr17_-_39306054 0.09 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr8_+_105235572 0.09 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_172468505 0.08 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr12_+_53662073 0.08 ENST00000553219.1
ENST00000257934.4
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr12_+_53662110 0.08 ENST00000552462.1
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr6_-_26199499 0.08 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr13_-_41593425 0.08 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_16759711 0.08 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_171034646 0.08 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr1_-_23670752 0.08 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr2_-_224467093 0.08 ENST00000305409.2
SCG2
secretogranin II
chr6_-_167040731 0.07 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_+_152879985 0.07 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr3_-_119813264 0.07 ENST00000264235.8
GSK3B
glycogen synthase kinase 3 beta
chr1_-_118472216 0.07 ENST00000369443.5
GDAP2
ganglioside induced differentiation associated protein 2
chr3_-_195538760 0.07 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr20_+_18447771 0.07 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr19_-_7040190 0.07 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr1_-_23670817 0.06 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr8_-_25281747 0.06 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr8_+_92261516 0.06 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr19_-_41870026 0.06 ENST00000243578.3
B9D2
B9 protein domain 2
chr1_-_23670813 0.06 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr19_-_7698599 0.06 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr4_-_89205879 0.06 ENST00000608933.1
ENST00000315194.4
ENST00000514204.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr7_-_137028498 0.06 ENST00000393083.2
PTN
pleiotrophin
chr19_+_45394477 0.06 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr4_-_120243545 0.06 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr3_-_52090461 0.06 ENST00000296483.6
ENST00000495880.1
DUSP7
dual specificity phosphatase 7
chr9_+_1050331 0.06 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2
doublesex and mab-3 related transcription factor 2
chr12_+_7014126 0.06 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr1_+_203463245 0.05 ENST00000367222.2
OPTC
opticin
chr15_-_31393910 0.05 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr9_+_80912059 0.05 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr6_-_100912785 0.05 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr9_-_136933615 0.05 ENST00000371834.2
BRD3
bromodomain containing 3
chr6_+_131571535 0.05 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr20_-_50722183 0.05 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr12_-_28123206 0.05 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr4_-_174255400 0.05 ENST00000506267.1
HMGB2
high mobility group box 2
chr1_-_17766198 0.05 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr11_-_71823266 0.05 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr6_+_34204642 0.05 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chrX_+_95939638 0.05 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr1_-_2461684 0.05 ENST00000378453.3
HES5
hes family bHLH transcription factor 5
chr16_+_69345243 0.05 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chrX_+_135730297 0.05 ENST00000370629.2
CD40LG
CD40 ligand
chr17_-_47045949 0.04 ENST00000357424.2
GIP
gastric inhibitory polypeptide
chr5_-_10761206 0.04 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chr1_-_152131703 0.04 ENST00000316073.3
RPTN
repetin
chr1_+_62901968 0.04 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
USP1
ubiquitin specific peptidase 1
chr11_-_71823796 0.04 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr1_+_42846443 0.04 ENST00000410070.2
ENST00000431473.3
RIMKLA
ribosomal modification protein rimK-like family member A
chr2_+_158114051 0.04 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr4_+_89206076 0.04 ENST00000500009.2
RP11-10L7.1
RP11-10L7.1
chr9_+_12693336 0.04 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr4_-_116034979 0.04 ENST00000264363.2
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr4_+_144354644 0.04 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr11_-_71823715 0.04 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr2_-_163008903 0.04 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr17_-_10017864 0.03 ENST00000323816.4
GAS7
growth arrest-specific 7
chr1_+_179923873 0.03 ENST00000367607.3
ENST00000491495.2
CEP350
centrosomal protein 350kDa
chr12_+_7014064 0.03 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr19_-_51522955 0.03 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr15_-_64673630 0.03 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr1_+_118472343 0.03 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr3_+_35722487 0.03 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr10_-_56560939 0.03 ENST00000373955.1
PCDH15
protocadherin-related 15
chr15_-_64673665 0.03 ENST00000300035.4
KIAA0101
KIAA0101
chr8_+_24298597 0.03 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr6_-_26032288 0.03 ENST00000244661.2
HIST1H3B
histone cluster 1, H3b
chr6_-_31782813 0.03 ENST00000375654.4
HSPA1L
heat shock 70kDa protein 1-like
chr17_-_9929581 0.03 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr8_-_18744528 0.03 ENST00000523619.1
PSD3
pleckstrin and Sec7 domain containing 3
chr1_+_40713573 0.03 ENST00000372766.3
TMCO2
transmembrane and coiled-coil domains 2
chr19_-_7968427 0.03 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr17_+_47448102 0.03 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr12_+_7013897 0.03 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr2_+_196313239 0.03 ENST00000413290.1
AC064834.1
AC064834.1
chr12_-_52828147 0.02 ENST00000252245.5
KRT75
keratin 75
chr12_-_101604185 0.02 ENST00000536262.2
SLC5A8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr8_+_24298531 0.02 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr19_-_19302931 0.02 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr3_-_141747950 0.02 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_-_64225508 0.02 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr2_-_77749474 0.02 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr5_+_31193847 0.02 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr12_-_28122980 0.02 ENST00000395868.3
ENST00000534890.1
PTHLH
parathyroid hormone-like hormone
chr4_+_71458012 0.02 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chrX_+_100353153 0.02 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
CENPI
centromere protein I
chr5_+_145826867 0.02 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr11_-_13517565 0.02 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr15_+_40733387 0.02 ENST00000416165.1
BAHD1
bromo adjacent homology domain containing 1
chr17_-_48785216 0.02 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr6_-_161695042 0.02 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr15_+_34638066 0.02 ENST00000333756.4
NUTM1
NUT midline carcinoma, family member 1
chr1_+_160370344 0.02 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr1_+_110881945 0.02 ENST00000602849.1
ENST00000487146.2
RBM15
RNA binding motif protein 15
chr7_-_99717463 0.01 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_-_25268104 0.01 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr6_-_139613269 0.01 ENST00000358430.3
TXLNB
taxilin beta
chrX_+_154444643 0.01 ENST00000286428.5
VBP1
von Hippel-Lindau binding protein 1
chr6_-_72130472 0.01 ENST00000426635.2
LINC00472
long intergenic non-protein coding RNA 472
chr7_-_137028534 0.01 ENST00000348225.2
PTN
pleiotrophin
chr8_-_42234745 0.01 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr6_-_161695074 0.01 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr1_+_152943122 0.01 ENST00000328051.2
SPRR4
small proline-rich protein 4
chrM_+_7586 0.01 ENST00000361739.1
MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr7_+_129984630 0.01 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
CPA5
carboxypeptidase A5
chr4_-_174255536 0.01 ENST00000446922.2
HMGB2
high mobility group box 2
chr15_+_76629064 0.01 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr4_-_74486217 0.01 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr6_+_26020672 0.00 ENST00000357647.3
HIST1H3A
histone cluster 1, H3a
chr10_+_99205894 0.00 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chrX_+_95939711 0.00 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr11_-_124190184 0.00 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr5_+_179159813 0.00 ENST00000292599.3
MAML1
mastermind-like 1 (Drosophila)
chr5_+_176811431 0.00 ENST00000512593.1
ENST00000324417.5
SLC34A1
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr10_+_99205959 0.00 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr3_-_157217328 0.00 ENST00000392832.2
ENST00000543418.1
VEPH1
ventricular zone expressed PH domain-containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.3 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.3 GO:0061743 motor learning(GO:0061743)
0.1 1.2 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 0.3 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.1 GO:1904339 superior temporal gyrus development(GO:0071109) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808) L-cystine transport(GO:0015811)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.0 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.2 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 1.3 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.4 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.2 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 1.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 1.2 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0015184 L-alanine transmembrane transporter activity(GO:0015180) L-cystine transmembrane transporter activity(GO:0015184) alanine transmembrane transporter activity(GO:0022858)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated