Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for EOMES
Z-value: 0.65
Motif logo
Transcription factors associated with EOMES
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EOMES | hg19_v2_chr3_-_27764190_27764208 | -0.33 | 1.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_184943610 Show fit | 2.44 |
ENST00000367511.3
|
family with sequence similarity 129, member A |
|
| chr17_+_77020325 Show fit | 1.98 |
ENST00000311661.4
|
C1q and tumor necrosis factor related protein 1 |
|
| chr15_+_89182156 Show fit | 1.97 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr2_-_225907150 Show fit | 1.95 |
ENST00000258390.7
|
dedicator of cytokinesis 10 |
|
| chr15_+_89182178 Show fit | 1.92 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89181974 Show fit | 1.53 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr3_-_64673668 Show fit | 1.47 |
ENST00000498707.1
|
ADAM metallopeptidase with thrombospondin type 1 motif, 9 |
|
| chr17_+_77020224 Show fit | 1.38 |
ENST00000339142.2
|
C1q and tumor necrosis factor related protein 1 |
|
| chr16_+_86544113 Show fit | 1.10 |
ENST00000262426.4
|
forkhead box F1 |
|
| chr7_+_55177416 Show fit | 1.03 |
ENST00000450046.1
ENST00000454757.2 |
epidermal growth factor receptor |
Network of associatons between targets according to the STRING database.
First level regulatory network of EOMES
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.4 | 3.4 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.2 | 2.3 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.0 | 2.2 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 0.0 | 2.0 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 1.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 1.5 | GO:0045636 | positive regulation of melanocyte differentiation(GO:0045636) |
| 0.3 | 1.3 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.3 | 1.2 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.1 | 1.2 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 3.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 1.3 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 1.2 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 1.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.3 | 1.0 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.0 | 0.8 | GO:0044453 | nuclear membrane part(GO:0044453) |
| 0.1 | 0.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 0.7 | GO:0070187 | telosome(GO:0070187) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 4.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 2.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 1.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 1.3 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 1.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 1.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.2 | 1.0 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.0 | 0.9 | GO:0022840 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.9 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 0.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.3 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 1.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 1.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 1.1 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 0.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.0 | 0.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |