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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for EPAS1_BCL3
Z-value: 1.24
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Transcription factors associated with EPAS1_BCL3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EPAS1 | hg19_v2_chr2_+_46524537_46524553 | 0.52 | 7.4e-03 | Click! |
| BCL3 | hg19_v2_chr19_+_45254529_45254578 | 0.45 | 2.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_43964055 Show fit | 3.14 |
ENST00000528572.1
|
chromosome 11 open reading frame 96 |
|
| chr20_-_36793663 Show fit | 2.74 |
ENST00000536701.1
ENST00000536724.1 |
transglutaminase 2 |
|
| chr3_-_18466026 Show fit | 2.54 |
ENST00000417717.2
|
SATB homeobox 1 |
|
| chr7_-_132261253 Show fit | 2.07 |
ENST00000321063.4
|
plexin A4 |
|
| chr15_-_69113218 Show fit | 1.96 |
ENST00000560303.1
ENST00000465139.2 |
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
|
| chr4_-_186732048 Show fit | 1.95 |
ENST00000448662.2
ENST00000439049.1 ENST00000420158.1 ENST00000431808.1 ENST00000319471.9 |
sorbin and SH3 domain containing 2 |
|
| chr8_-_81083890 Show fit | 1.94 |
ENST00000518937.1
|
tumor protein D52 |
|
| chr1_+_110453109 Show fit | 1.92 |
ENST00000525659.1
|
colony stimulating factor 1 (macrophage) |
|
| chr1_+_61547894 Show fit | 1.90 |
ENST00000403491.3
|
nuclear factor I/A |
|
| chr2_-_188312971 Show fit | 1.82 |
ENST00000410068.1
ENST00000447403.1 ENST00000410102.1 |
calcitonin receptor-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of EPAS1_BCL3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.0 | GO:1902228 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.2 | 4.7 | GO:0072189 | ureter development(GO:0072189) |
| 1.3 | 4.0 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 0.1 | 3.7 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.2 | 3.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 2.9 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.4 | 2.6 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.8 | 2.4 | GO:0014740 | negative regulation of muscle hyperplasia(GO:0014740) |
| 0.8 | 2.3 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.0 | 2.1 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 1.0 | 6.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 4.3 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.2 | 3.4 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 3.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.3 | 2.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 2.6 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 2.4 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 2.3 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 1.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.0 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.4 | 4.0 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.3 | 3.8 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 3.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 3.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 2.9 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 2.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 2.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.6 | 2.3 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.5 | 2.3 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 5.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 3.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 3.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 2.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 2.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.9 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 2.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 2.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 2.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.1 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 2.0 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.1 | 1.8 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 1.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |