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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for EPAS1_BCL3

Z-value: 1.24

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Transcription factors associated with EPAS1_BCL3

Gene Symbol Gene ID Gene Info
ENSG00000116016.9 endothelial PAS domain protein 1
ENSG00000069399.8 BCL3 transcription coactivator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EPAS1hg19_v2_chr2_+_46524537_465245530.527.4e-03Click!
BCL3hg19_v2_chr19_+_45254529_452545780.452.5e-02Click!

Activity profile of EPAS1_BCL3 motif

Sorted Z-values of EPAS1_BCL3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_43964055 3.14 ENST00000528572.1
chromosome 11 open reading frame 96
chr20_-_36793663 2.74 ENST00000536701.1
ENST00000536724.1
transglutaminase 2
chr3_-_18466026 2.54 ENST00000417717.2
SATB homeobox 1
chr7_-_132261253 2.07 ENST00000321063.4
plexin A4
chr15_-_69113218 1.96 ENST00000560303.1
ENST00000465139.2
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_-_186732048 1.95 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
sorbin and SH3 domain containing 2
chr8_-_81083890 1.94 ENST00000518937.1
tumor protein D52
chr1_+_110453109 1.92 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr1_+_61547894 1.90 ENST00000403491.3
nuclear factor I/A
chr2_-_188312971 1.82 ENST00000410068.1
ENST00000447403.1
ENST00000410102.1
calcitonin receptor-like
chr20_+_34680620 1.76 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
erythrocyte membrane protein band 4.1-like 1
chr14_-_92413353 1.73 ENST00000556154.1
fibulin 5
chr3_-_52479043 1.71 ENST00000231721.2
ENST00000475739.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr1_+_110453608 1.66 ENST00000369801.1
colony stimulating factor 1 (macrophage)
chr3_-_32022733 1.61 ENST00000438237.2
ENST00000396556.2
oxysterol binding protein-like 10
chr4_+_41361616 1.54 ENST00000513024.1
LIM and calponin homology domains 1
chr1_+_61548225 1.52 ENST00000371187.3
nuclear factor I/A
chr4_-_70626314 1.49 ENST00000510821.1
sulfotransferase family, cytosolic, 1B, member 1
chr4_+_140586922 1.47 ENST00000265498.1
ENST00000506797.1
microsomal glutathione S-transferase 2
chr1_+_110453462 1.46 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr14_-_54420133 1.44 ENST00000559501.1
ENST00000558984.1
bone morphogenetic protein 4
chr6_-_40555176 1.43 ENST00000338305.6
leucine rich repeat and fibronectin type III domain containing 2
chr2_-_238499303 1.42 ENST00000409576.1
RAB17, member RAS oncogene family
chr22_-_37880543 1.35 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_+_102686820 1.31 ENST00000409929.1
ENST00000424272.1
interleukin 1 receptor, type I
chr3_-_168865522 1.31 ENST00000464456.1
MDS1 and EVI1 complex locus
chr7_-_150329421 1.29 ENST00000493969.1
ENST00000328902.5
GTPase, IMAP family member 6
chr3_-_142607740 1.29 ENST00000485766.1
procollagen C-endopeptidase enhancer 2
chr20_-_36793774 1.28 ENST00000361475.2
transglutaminase 2
chr7_+_150688083 1.21 ENST00000297494.3
nitric oxide synthase 3 (endothelial cell)
chr19_-_42806723 1.21 ENST00000262890.3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr19_+_30863271 1.21 ENST00000355537.3
zinc finger protein 536
chr8_-_89339705 1.19 ENST00000286614.6
matrix metallopeptidase 16 (membrane-inserted)
chr7_+_150688166 1.18 ENST00000461406.1
nitric oxide synthase 3 (endothelial cell)
chr9_+_34652164 1.16 ENST00000441545.2
ENST00000553620.1
interleukin 11 receptor, alpha
chr8_+_21915368 1.15 ENST00000265800.5
ENST00000517418.1
dematin actin binding protein
chr4_-_70626430 1.14 ENST00000310613.3
sulfotransferase family, cytosolic, 1B, member 1
chr4_-_102268484 1.14 ENST00000394853.4
protein phosphatase 3, catalytic subunit, alpha isozyme
chr13_+_114238997 1.13 ENST00000538138.1
ENST00000375370.5
transcription factor Dp-1
chr2_+_20646824 1.12 ENST00000272233.4
ras homolog family member B
chr4_-_102268628 1.12 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_+_61548374 1.07 ENST00000485903.2
ENST00000371185.2
ENST00000371184.2
nuclear factor I/A
chr6_-_36807762 1.02 ENST00000244751.2
copine V
chr17_-_7080227 1.02 ENST00000574330.1
asialoglycoprotein receptor 1
chr6_-_16761678 0.98 ENST00000244769.4
ENST00000436367.1
ataxin 1
chr4_+_41362796 0.97 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIM and calponin homology domains 1
chr7_+_136553370 0.96 ENST00000445907.2
cholinergic receptor, muscarinic 2
chr14_-_71107921 0.96 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
chr4_+_156588806 0.95 ENST00000513574.1
guanylate cyclase 1, soluble, alpha 3
chr21_+_46117087 0.92 ENST00000400365.3
keratin associated protein 10-12
chr19_+_45973120 0.91 ENST00000592811.1
ENST00000586615.1
FBJ murine osteosarcoma viral oncogene homolog B
chr18_+_77155856 0.91 ENST00000253506.5
ENST00000591814.1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr8_-_81083341 0.91 ENST00000519303.2
tumor protein D52
chr14_+_105047478 0.91 ENST00000410013.1
chromosome 14 open reading frame 180
chr19_+_1407733 0.91 ENST00000592453.1
DAZ associated protein 1
chr6_+_130686856 0.89 ENST00000296978.3
transmembrane protein 200A
chr1_+_203595903 0.89 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
ATPase, Ca++ transporting, plasma membrane 4
chr12_+_20522179 0.88 ENST00000359062.3
phosphodiesterase 3A, cGMP-inhibited
chr11_-_414948 0.88 ENST00000530494.1
ENST00000528209.1
ENST00000431843.2
ENST00000528058.1
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr8_+_68864330 0.87 ENST00000288368.4
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_92495528 0.86 ENST00000370383.4
epoxide hydrolase 4
chr7_-_50518022 0.85 ENST00000356889.4
ENST00000420829.1
ENST00000448788.1
ENST00000395556.2
ENST00000422854.1
ENST00000435566.1
ENST00000433017.1
fidgetin-like 1
chr3_-_171177852 0.84 ENST00000284483.8
ENST00000475336.1
ENST00000357327.5
ENST00000460047.1
ENST00000488470.1
ENST00000470834.1
TRAF2 and NCK interacting kinase
chr3_+_134514093 0.84 ENST00000398015.3
EPH receptor B1
chr1_+_203595689 0.83 ENST00000357681.5
ATPase, Ca++ transporting, plasma membrane 4
chr17_+_2699697 0.83 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1 GTPase activating protein 2
chr22_-_39637135 0.82 ENST00000440375.1
platelet-derived growth factor beta polypeptide
chr5_-_61031495 0.81 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
chr17_+_61571746 0.80 ENST00000579409.1
angiotensin I converting enzyme
chr3_-_18466787 0.79 ENST00000338745.6
ENST00000450898.1
SATB homeobox 1
chr11_-_89224488 0.78 ENST00000534731.1
ENST00000527626.1
NADPH oxidase 4
chr11_-_89224508 0.76 ENST00000525196.1
NADPH oxidase 4
chr1_+_110453203 0.76 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
colony stimulating factor 1 (macrophage)
chr8_+_21916710 0.76 ENST00000523266.1
ENST00000519907.1
dematin actin binding protein
chr6_+_38690622 0.76 ENST00000327475.6
dynein, axonemal, heavy chain 8
chr17_+_39382900 0.76 ENST00000377721.3
ENST00000455970.2
keratin associated protein 9-2
chr12_+_26348582 0.75 ENST00000535504.1
sarcospan
chr8_+_21916680 0.74 ENST00000358242.3
ENST00000415253.1
dematin actin binding protein
chr17_+_4618734 0.72 ENST00000571206.1
arrestin, beta 2
chr2_+_85360499 0.72 ENST00000282111.3
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr12_-_49259643 0.72 ENST00000309739.5
Rho family GTPase 1
chr4_+_86748898 0.72 ENST00000509300.1
Rho GTPase activating protein 24
chr9_-_39288092 0.71 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
contactin associated protein-like 3
chr9_-_14314518 0.68 ENST00000397581.2
nuclear factor I/B
chr22_-_29075853 0.68 ENST00000397906.2
tetratricopeptide repeat domain 28
chr11_-_89224299 0.68 ENST00000343727.5
ENST00000531342.1
ENST00000375979.3
NADPH oxidase 4
chr15_+_66994561 0.68 ENST00000288840.5
SMAD family member 6
chr2_+_11273179 0.67 ENST00000381585.3
ENST00000405022.3
chromosome 2 open reading frame 50
chr6_+_12012536 0.67 ENST00000379388.2
human immunodeficiency virus type I enhancer binding protein 1
chr7_+_136553824 0.66 ENST00000320658.5
ENST00000453373.1
ENST00000397608.3
ENST00000402486.3
ENST00000401861.1
cholinergic receptor, muscarinic 2
chr11_+_10472223 0.65 ENST00000396554.3
ENST00000524866.1
adenosine monophosphate deaminase 3
chr20_+_10199468 0.65 ENST00000254976.2
ENST00000304886.2
synaptosomal-associated protein, 25kDa
chr2_-_220436248 0.64 ENST00000265318.4
obscurin-like 1
chr3_-_15540055 0.64 ENST00000605797.1
ENST00000435459.2
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr18_+_77155942 0.64 ENST00000397790.2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr21_+_37507210 0.64 ENST00000290354.5
carbonyl reductase 3
chr22_+_19705928 0.63 ENST00000383045.3
ENST00000438754.2
septin 5
chr9_-_72287191 0.63 ENST00000265381.4
amyloid beta (A4) precursor protein-binding, family A, member 1
chr3_-_142608001 0.63 ENST00000295992.3
procollagen C-endopeptidase enhancer 2
chr11_-_74022658 0.62 ENST00000427714.2
ENST00000331597.4
prolyl 4-hydroxylase, alpha polypeptide III
chr11_-_89224638 0.61 ENST00000535633.1
ENST00000263317.4
NADPH oxidase 4
chr4_-_89152474 0.61 ENST00000515655.1
ATP-binding cassette, sub-family G (WHITE), member 2
chr8_-_145691031 0.61 ENST00000424149.2
ENST00000530637.1
ENST00000306145.5
cysteine/histidine-rich 1
chr5_-_39425068 0.60 ENST00000515700.1
ENST00000339788.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr12_+_79258547 0.60 ENST00000457153.2
synaptotagmin I
chr21_-_31312230 0.60 ENST00000399907.1
ENST00000399909.1
glutamate receptor, ionotropic, kainate 1
chr1_-_85930246 0.60 ENST00000426972.3
dimethylarginine dimethylaminohydrolase 1
chr1_+_153651078 0.59 ENST00000368680.3
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr19_-_42806842 0.59 ENST00000596265.1
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr6_+_74405501 0.58 ENST00000437994.2
ENST00000422508.2
CD109 molecule
chr10_-_30348439 0.57 ENST00000375377.1
KIAA1462
chr12_+_79258444 0.57 ENST00000261205.4
synaptotagmin I
chr22_-_39636914 0.57 ENST00000381551.4
platelet-derived growth factor beta polypeptide
chr6_-_42690312 0.57 ENST00000230381.5
peripherin 2 (retinal degeneration, slow)
chr14_+_96505659 0.56 ENST00000555004.1
chromosome 14 open reading frame 132
chr9_-_20622478 0.55 ENST00000355930.6
ENST00000380338.4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_159080806 0.54 ENST00000590648.1
family with sequence similarity 198, member B
chr14_+_61995722 0.54 ENST00000556347.1
RP11-47I22.4
chr2_-_85645545 0.54 ENST00000409275.1
capping protein (actin filament), gelsolin-like
chr3_+_37903432 0.54 ENST00000443503.2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr11_-_73471655 0.53 ENST00000400470.2
RAB6A, member RAS oncogene family
chr19_-_42806919 0.53 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr4_+_144258021 0.53 ENST00000262994.4
GRB2-associated binding protein 1
chr7_-_38398721 0.52 ENST00000390346.2
T cell receptor gamma variable 3
chr19_+_36705504 0.52 ENST00000456324.1
zinc finger protein 146
chr8_+_10530155 0.52 ENST00000521818.1
chromosome 8 open reading frame 74
chr4_-_141075330 0.52 ENST00000509479.2
mastermind-like 3 (Drosophila)
chr6_+_31620191 0.51 ENST00000375918.2
ENST00000375920.4
apolipoprotein M
chr4_+_86749045 0.51 ENST00000514229.1
Rho GTPase activating protein 24
chr1_-_44497024 0.50 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_44497118 0.50 ENST00000537678.1
ENST00000466926.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr6_+_74405804 0.50 ENST00000287097.5
CD109 molecule
chr2_+_85646054 0.50 ENST00000389938.2
SH2 domain containing 6
chr3_+_52009066 0.49 ENST00000458031.2
ENST00000463937.1
ENST00000273596.3
aminoacylase 1
ABHD14A-ACY1 readthrough (NMD candidate)
abhydrolase domain containing 14A
chr3_-_9291063 0.49 ENST00000383836.3
SLIT-ROBO Rho GTPase activating protein 3
chr19_+_18530146 0.49 ENST00000348495.6
ENST00000270061.7
single stranded DNA binding protein 4
chr1_+_82266053 0.49 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
latrophilin 2
chr19_+_13106383 0.49 ENST00000397661.2
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_86046433 0.48 ENST00000451137.2
cysteine-rich, angiogenic inducer, 61
chr3_+_186435137 0.48 ENST00000447445.1
kininogen 1
chr7_+_114562172 0.48 ENST00000393486.1
ENST00000257724.3
MyoD family inhibitor domain containing
chr18_-_53089723 0.48 ENST00000561992.1
ENST00000562512.2
transcription factor 4
chr6_+_36646435 0.48 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr21_-_31311818 0.48 ENST00000535441.1
ENST00000309434.7
ENST00000327783.4
ENST00000389124.2
ENST00000389125.3
ENST00000399913.1
glutamate receptor, ionotropic, kainate 1
chr14_-_105420241 0.48 ENST00000557457.1
AHNAK nucleoprotein 2
chr17_-_56406117 0.47 ENST00000268893.6
ENST00000355701.3
benzodiazepine receptor (peripheral) associated protein 1
chr20_-_2781222 0.47 ENST00000380605.2
carboxypeptidase X (M14 family), member 1
chr18_+_6729698 0.47 ENST00000383472.4
Rho GTPase activating protein 28
chrX_+_135229600 0.46 ENST00000370690.3
four and a half LIM domains 1
chr18_+_61254534 0.46 ENST00000269489.5
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr7_+_29519486 0.46 ENST00000409041.4
chimerin 2
chr2_+_219247021 0.45 ENST00000539932.1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr6_-_84419101 0.45 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
synaptosomal-associated protein, 91kDa
chr9_+_43684902 0.45 ENST00000377564.3
ENST00000276974.6
contactin associated protein-like 3B
chr1_+_77747656 0.45 ENST00000354567.2
adenylate kinase 5
chr9_-_13165457 0.45 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
multiple PDZ domain protein
chr9_-_14314566 0.45 ENST00000397579.2
nuclear factor I/B
chrX_+_135229731 0.44 ENST00000420362.1
four and a half LIM domains 1
chr10_+_104154229 0.44 ENST00000428099.1
ENST00000369966.3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_+_74881398 0.44 ENST00000339773.5
ENST00000434486.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
chr11_+_64879317 0.44 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
transmembrane 7 superfamily member 2
chr19_-_37407172 0.44 ENST00000391711.3
zinc finger protein 829
chr19_+_40195101 0.43 ENST00000360675.3
ENST00000601802.1
lectin, galactoside-binding, soluble, 14
chr19_+_10765699 0.43 ENST00000590009.1
interleukin enhancer binding factor 3, 90kDa
chrX_+_135229559 0.43 ENST00000394155.2
four and a half LIM domains 1
chr19_+_41117770 0.43 ENST00000601032.1
latent transforming growth factor beta binding protein 4
chr17_+_73089382 0.43 ENST00000538213.2
ENST00000584118.1
solute carrier family 16 (monocarboxylate transporter), member 5
chr5_+_52285144 0.43 ENST00000296585.5
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr4_-_78740511 0.43 ENST00000504123.1
ENST00000264903.4
ENST00000515441.1
CCR4-NOT transcription complex, subunit 6-like
chr5_+_175299743 0.42 ENST00000502265.1
complexin 2
chr3_-_183735731 0.42 ENST00000334444.6
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr3_+_154958715 0.41 ENST00000462531.1
ENST00000490497.1
RP11-451G4.1
chr13_+_36050881 0.41 ENST00000537702.1
neurobeachin
chr4_+_103423055 0.41 ENST00000505458.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_-_38743878 0.40 ENST00000587515.1
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr16_+_82068830 0.40 ENST00000199936.4
hydroxysteroid (17-beta) dehydrogenase 2
chr19_+_34287751 0.40 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
potassium channel tetramerization domain containing 15
chr4_+_144257915 0.39 ENST00000262995.4
GRB2-associated binding protein 1
chr7_-_38389573 0.39 ENST00000390344.2
T cell receptor gamma variable 5
chr12_+_98909351 0.39 ENST00000343315.5
ENST00000266732.4
ENST00000393053.2
thymopoietin
chr5_-_81046904 0.39 ENST00000515395.1
single-stranded DNA binding protein 2
chr4_-_46996424 0.39 ENST00000264318.3
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr19_+_49404041 0.38 ENST00000263273.5
ENST00000424608.1
nucleobindin 1
chr7_-_142247606 0.38 ENST00000390361.3
T cell receptor beta variable 7-3
chr5_-_81046841 0.38 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
single-stranded DNA binding protein 2
chr1_+_210406121 0.38 ENST00000367012.3
SERTA domain containing 4
chr8_+_27348626 0.38 ENST00000517536.1
epoxide hydrolase 2, cytoplasmic
chr3_-_169381183 0.38 ENST00000494292.1
MDS1 and EVI1 complex locus
chr14_-_54955721 0.38 ENST00000554908.1
glia maturation factor, beta
chrX_+_107069063 0.38 ENST00000262843.6
midline 2
chr19_-_43586820 0.38 ENST00000406487.1
pregnancy specific beta-1-glycoprotein 2
chr12_-_23737534 0.37 ENST00000396007.2
SRY (sex determining region Y)-box 5
chr2_+_56411131 0.37 ENST00000407595.2
coiled-coil domain containing 85A
chr19_+_45844032 0.37 ENST00000589837.1
kinesin light chain 3
chr15_-_70390213 0.37 ENST00000557997.1
ENST00000317509.8
ENST00000442299.2
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr6_+_108881012 0.36 ENST00000343882.6
forkhead box O3
chr12_-_96794143 0.36 ENST00000543119.2
cyclin-dependent kinase 17
chr7_+_127233689 0.36 ENST00000265825.5
ENST00000420086.2
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr12_-_6716569 0.36 ENST00000544040.1
ENST00000545942.1
chromodomain helicase DNA binding protein 4
chr12_-_10007448 0.36 ENST00000538152.1
C-type lectin domain family 2, member B

Network of associatons between targets according to the STRING database.

First level regulatory network of EPAS1_BCL3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
1.2 6.0 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.8 2.4 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.8 2.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.6 1.7 GO:1903248 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.5 1.6 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)
0.5 1.4 GO:0061216 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.4 2.6 GO:0070560 protein secretion by platelet(GO:0070560)
0.4 1.3 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.4 1.2 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.4 1.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.4 GO:0072255 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.3 1.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.3 0.8 GO:0099545 trans-synaptic signaling by trans-synaptic complex(GO:0099545) negative regulation of satellite cell differentiation(GO:1902725)
0.2 0.7 GO:0055073 cadmium ion homeostasis(GO:0055073) divalent metal ion export(GO:0070839)
0.2 1.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.2 0.6 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.2 0.8 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.2 3.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 4.7 GO:0072189 ureter development(GO:0072189)
0.2 0.9 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.2 1.1 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 0.5 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.2 1.9 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.2 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 0.5 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.2 1.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 1.0 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.2 0.6 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.2 0.5 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.2 0.6 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.9 GO:0071321 cellular response to cGMP(GO:0071321)
0.1 0.7 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1 0.4 GO:0033341 regulation of collagen binding(GO:0033341)
0.1 0.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 1.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.5 GO:0070813 hydrogen sulfide metabolic process(GO:0070813)
0.1 0.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.8 GO:0006196 AMP catabolic process(GO:0006196)
0.1 0.6 GO:0042374 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.1 0.9 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 1.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.3 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.5 GO:0009183 ADP biosynthetic process(GO:0006172) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183)
0.1 1.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.3 GO:0045799 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.4 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.4 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.1 2.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 3.7 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.2 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 0.6 GO:0072553 terminal button organization(GO:0072553)
0.1 0.5 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.1 0.9 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.5 GO:0015692 lead ion transport(GO:0015692)
0.1 0.6 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.1 0.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.3 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 1.1 GO:0015886 heme transport(GO:0015886)
0.1 0.2 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.1 0.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.4 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.3 GO:0050968 detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1 0.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.3 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 0.3 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.1 0.2 GO:2000854 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) cellular response to cocaine(GO:0071314) positive regulation of corticosterone secretion(GO:2000854)
0.1 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.1 0.9 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.1 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.1 0.3 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.3 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.4 GO:0097327 response to antineoplastic agent(GO:0097327)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.2 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.2 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.4 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
0.1 0.2 GO:0071344 diphosphate metabolic process(GO:0071344)
0.1 0.2 GO:0060849 radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.9 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.2 GO:0061743 motor learning(GO:0061743)
0.1 0.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 0.2 GO:0061056 sclerotome development(GO:0061056)
0.1 0.8 GO:0016322 neuron remodeling(GO:0016322)
0.1 1.7 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.1 0.2 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.5 GO:0060591 chondroblast differentiation(GO:0060591)
0.1 0.3 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.1 0.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:0031133 regulation of axon diameter(GO:0031133)
0.0 0.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
0.0 1.3 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 0.4 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.6 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.2 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.1 GO:1905064 negative regulation of vascular smooth muscle cell differentiation(GO:1905064)
0.0 0.3 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.2 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 0.2 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.5 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.2 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.1 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.0 2.1 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 1.7 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 0.2 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 1.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.4 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.8 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
0.0 0.3 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.0 0.1 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.4 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.2 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.0 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.0 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.0 0.7 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.2 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
0.0 1.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.2 GO:0001575 globoside metabolic process(GO:0001575)
0.0 0.6 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 0.1 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.2 GO:0032960 regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.6 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.3 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.1 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.2 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.9 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.1 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.2 GO:0097503 sialylation(GO:0097503)
0.0 0.1 GO:0019075 virus maturation(GO:0019075)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.5 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.2 GO:0071233 cellular response to leucine(GO:0071233)
0.0 0.9 GO:1903859 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.1 GO:0007442 hindgut morphogenesis(GO:0007442) embryonic hindgut morphogenesis(GO:0048619)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.8 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.4 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.1 GO:1903570 coronary vein morphogenesis(GO:0003169) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) cardiac vascular smooth muscle cell development(GO:0060948) positive regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061419) positive regulation of retinal ganglion cell axon guidance(GO:1902336) regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.3 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.0 0.4 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.5 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:1902219 erythropoietin-mediated signaling pathway(GO:0038162) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.5 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.1 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.2 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727) regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.3 GO:0045008 depyrimidination(GO:0045008)
0.0 0.1 GO:0071105 response to interleukin-11(GO:0071105)
0.0 0.2 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.4 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.1 GO:1901016 regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.3 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.2 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.1 GO:0060025 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) regulation of synaptic activity(GO:0060025)
0.0 0.5 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 0.0 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.3 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.2 GO:0099638 endosome to plasma membrane protein transport(GO:0099638)
0.0 0.4 GO:0060292 long term synaptic depression(GO:0060292)
0.0 1.9 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.0 GO:0097032 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.1 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.5 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.2 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.4 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.2 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.1 GO:0002329 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.2 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0030167 proteoglycan catabolic process(GO:0030167) heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.0 GO:0050779 RNA destabilization(GO:0050779)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.6 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.1 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.3 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.1 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 1.6 GO:0032279 asymmetric synapse(GO:0032279)
0.3 2.7 GO:0071953 elastic fiber(GO:0071953)
0.3 2.3 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.2 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2 3.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 0.5 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.2 0.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.4 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 0.7 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 1.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 0.9 GO:1990393 3M complex(GO:1990393)
0.1 2.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.3 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 1.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.4 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.5 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.3 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.1 0.4 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 0.2 GO:0001534 radial spoke(GO:0001534)
0.1 0.8 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 3.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.2 GO:0005879 axonemal microtubule(GO:0005879)
0.1 0.2 GO:0005607 laminin-2 complex(GO:0005607)
0.1 0.2 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 1.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.5 GO:0060091 kinocilium(GO:0060091)
0.0 0.4 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0005940 septin ring(GO:0005940) septin collar(GO:0032173)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.6 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 2.4 GO:0045095 keratin filament(GO:0045095)
0.0 1.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0031523 Myb complex(GO:0031523)
0.0 0.6 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405) nuclear pore nuclear basket(GO:0044615)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.6 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.0 9.1 GO:0005925 focal adhesion(GO:0005925)
0.0 4.3 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.1 GO:0031906 late endosome lumen(GO:0031906)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.0 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.6 1.7 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.6 2.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.5 1.5 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.5 2.3 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.5 1.8 GO:0004948 calcitonin receptor activity(GO:0004948)
0.4 4.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 1.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.3 0.9 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.3 1.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.3 3.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.7 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.2 0.7 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.2 0.7 GO:0070698 type I activin receptor binding(GO:0070698)
0.2 2.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 0.6 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.2 1.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 1.2 GO:0034046 poly(G) binding(GO:0034046)
0.2 1.5 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.2 0.5 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 0.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 1.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 1.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.8 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 0.4 GO:0032440 2-alkenal reductase [NAD(P)] activity(GO:0032440)
0.1 0.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.1 GO:0032089 NACHT domain binding(GO:0032089)
0.1 2.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 3.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.4 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.6 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 1.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 2.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.4 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.1 0.5 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.6 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.6 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.3 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 1.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.6 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.3 GO:0043398 HLH domain binding(GO:0043398)
0.1 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 1.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.2 GO:0004915 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.1 0.3 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.3 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.2 GO:0052856 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.1 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.2 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.8 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.0 0.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.1 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 1.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0005119 smoothened binding(GO:0005119)
0.0 0.3 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.6 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0097604 temperature-gated cation channel activity(GO:0097604)
0.0 0.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 1.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.7 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.1 GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.0 0.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.3 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.2 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.4 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 1.6 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.2 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0033677 DNA/RNA helicase activity(GO:0033677)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 1.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 3.4 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.6 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.1 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.0 0.1 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.3 GO:0043295 glutathione binding(GO:0043295)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.0 0.0 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.0 0.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.0 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.0 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 1.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0071837 HMG box domain binding(GO:0071837)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 5.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 3.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.5 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.4 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 2.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.8 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 1.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.7 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 2.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 3.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.3 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.3 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 5.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.3 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 2.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.8 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 2.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.1 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 1.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 1.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 3.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.6 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 1.6 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 2.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.4 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 1.1 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 2.0 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis