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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ESR1
Z-value: 1.06
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Transcription factors associated with ESR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR1 | hg19_v2_chr6_+_152128810_152128827 | 0.38 | 5.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_23046750 Show fit | 4.57 |
ENST00000390307.2
|
immunoglobulin lambda variable 3-22 (gene/pseudogene) |
|
| chr12_-_42877726 Show fit | 3.65 |
ENST00000548696.1
|
prickle homolog 1 (Drosophila) |
|
| chr1_+_212458834 Show fit | 2.89 |
ENST00000261461.2
|
protein phosphatase 2, regulatory subunit B', alpha |
|
| chr12_-_42877764 Show fit | 2.61 |
ENST00000455697.1
|
prickle homolog 1 (Drosophila) |
|
| chr3_-_148804275 Show fit | 2.30 |
ENST00000392912.2
ENST00000465259.1 ENST00000310053.5 ENST00000494055.1 |
helicase-like transcription factor |
|
| chr22_+_22936998 Show fit | 2.18 |
ENST00000390303.2
|
immunoglobulin lambda variable 3-32 (non-functional) |
|
| chr12_-_95044309 Show fit | 1.91 |
ENST00000261226.4
|
transmembrane and coiled-coil domain family 3 |
|
| chr19_-_1513188 Show fit | 1.91 |
ENST00000330475.4
|
ADAMTS-like 5 |
|
| chr3_+_38017264 Show fit | 1.85 |
ENST00000436654.1
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
|
| chr3_-_122512619 Show fit | 1.84 |
ENST00000383659.1
ENST00000306103.2 |
HSPB (heat shock 27kDa) associated protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.3 | GO:2000691 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.0 | 3.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 3.8 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.0 | 3.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.0 | 2.9 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.5 | 2.9 | GO:0090219 | negative regulation of lipid kinase activity(GO:0090219) |
| 0.0 | 2.8 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.0 | 2.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.3 | 2.6 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 2.4 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 2.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 2.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 2.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 2.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 2.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.4 | 1.9 | GO:0097123 | cyclin A1-CDK2 complex(GO:0097123) |
| 0.0 | 1.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 1.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.5 | GO:0043198 | dendritic shaft(GO:0043198) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 3.7 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.1 | 3.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 3.1 | GO:0008201 | heparin binding(GO:0008201) |
| 0.6 | 2.9 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.3 | 2.6 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 2.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 2.2 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.3 | 2.0 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 3.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.6 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 2.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 1.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.9 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 1.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 1.8 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 1.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 1.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 1.4 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 1.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.2 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 1.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |