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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ESRRA_ESR2
Z-value: 2.40
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR2 | hg19_v2_chr14_-_64804814_64804842 | 0.86 | 4.7e-08 | Click! |
| ESRRA | hg19_v2_chr11_+_64073022_64073056 | 0.25 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_10197463 Show fit | 9.16 |
ENST00000590378.1
ENST00000397881.3 |
chromosome 19 open reading frame 66 |
|
| chr10_-_49812997 Show fit | 8.18 |
ENST00000417912.2
|
Rho GTPase activating protein 22 |
|
| chr4_-_681114 Show fit | 7.97 |
ENST00000503156.1
|
major facilitator superfamily domain containing 7 |
|
| chr14_+_24630465 Show fit | 7.87 |
ENST00000557894.1
ENST00000559284.1 ENST00000560275.1 |
interferon regulatory factor 9 |
|
| chr10_-_49860525 Show fit | 7.38 |
ENST00000435790.2
|
Rho GTPase activating protein 22 |
|
| chr11_-_102668879 Show fit | 7.36 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr12_+_113416191 Show fit | 6.79 |
ENST00000342315.4
ENST00000392583.2 |
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr12_+_113344755 Show fit | 6.77 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr19_+_18284477 Show fit | 6.63 |
ENST00000407280.3
|
interferon, gamma-inducible protein 30 |
|
| chr17_-_34207295 Show fit | 6.13 |
ENST00000463941.1
ENST00000293272.3 |
chemokine (C-C motif) ligand 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 36.3 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.3 | 31.6 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.5 | 15.7 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 2.8 | 14.0 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.2 | 13.3 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 1.3 | 12.9 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 2.5 | 12.4 | GO:0003070 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 2.8 | 11.1 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.2 | 11.0 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.2 | 10.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 2.5 | 22.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 21.0 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.8 | 18.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 16.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 15.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.7 | 14.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 10.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.9 | 9.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.3 | 8.6 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.2 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.8 | 23.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 23.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 2.1 | 23.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.5 | 20.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 16.7 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.1 | 16.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.3 | 15.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 1.6 | 14.2 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 2.8 | 14.0 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.6 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 20.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 20.6 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.2 | 18.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 15.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 15.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 12.1 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 9.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 9.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 9.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 58.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 32.6 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 21.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 18.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 17.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.3 | 17.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 13.8 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 11.9 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.2 | 11.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 11.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |