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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ESRRB_ESRRG
Z-value: 0.71
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Transcription factors associated with ESRRB_ESRRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRG | hg19_v2_chr1_-_217250231_217250349 | -0.24 | 2.6e-01 | Click! |
| ESRRB | hg19_v2_chr14_+_76776957_76777061 | -0.01 | 9.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_123339343 Show fit | 1.85 |
ENST00000578202.1
|
myosin light chain kinase |
|
| chr3_-_123339418 Show fit | 1.81 |
ENST00000583087.1
|
myosin light chain kinase |
|
| chr4_-_76957214 Show fit | 1.03 |
ENST00000306621.3
|
chemokine (C-X-C motif) ligand 11 |
|
| chr16_+_56623433 Show fit | 0.77 |
ENST00000570176.1
|
metallothionein 3 |
|
| chr12_-_111358372 Show fit | 0.76 |
ENST00000548438.1
ENST00000228841.8 |
myosin, light chain 2, regulatory, cardiac, slow |
|
| chr6_-_9933500 Show fit | 0.68 |
ENST00000492169.1
|
orofacial cleft 1 candidate 1 |
|
| chrX_+_52927576 Show fit | 0.61 |
ENST00000416841.2
|
family with sequence similarity 156, member B |
|
| chr4_+_24797085 Show fit | 0.60 |
ENST00000382120.3
|
superoxide dismutase 3, extracellular |
|
| chr3_-_42743006 Show fit | 0.59 |
ENST00000310417.5
|
hedgehog acyltransferase-like |
|
| chr6_+_107349392 Show fit | 0.59 |
ENST00000443043.1
ENST00000405204.2 ENST00000311381.5 |
chromosome 6 open reading frame 203 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRB_ESRRG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.7 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.3 | 1.1 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.3 | 1.0 | GO:0048597 | B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) |
| 0.2 | 1.0 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.1 | 1.0 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.3 | 0.9 | GO:0006500 | N-terminal protein palmitoylation(GO:0006500) |
| 0.3 | 0.8 | GO:2000374 | cadmium ion homeostasis(GO:0055073) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374) |
| 0.1 | 0.8 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.0 | 0.8 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.2 | 0.7 | GO:0060697 | positive regulation of phospholipid catabolic process(GO:0060697) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 1.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 1.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 1.0 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.0 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 1.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.3 | 0.8 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.1 | 0.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 0.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.7 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 1.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 1.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 1.0 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.0 | 1.0 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.8 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 0.8 | GO:0001727 | lipid kinase activity(GO:0001727) |
| 0.1 | 0.8 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.0 | 0.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.7 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.0 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.5 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 0.5 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 2.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 1.4 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 1.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.0 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |