Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for ETV1_ERF_FEV_ELF1
Z-value: 1.20
Motif logo
Transcription factors associated with ETV1_ERF_FEV_ELF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000006468.9 | ETS variant transcription factor 1 | |
| ENSG00000105722.5 | ETS2 repressor factor | |
| ENSG00000163497.2 | FEV transcription factor, ETS family member | |
| ENSG00000120690.9 | E74 like ETS transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV1 | hg19_v2_chr7_-_14026123_14026139 | -0.73 | 4.1e-05 | Click! |
| ERF | hg19_v2_chr19_-_42759300_42759324 | -0.36 | 8.0e-02 | Click! |
| ELF1 | hg19_v2_chr13_-_41593425_41593480 | 0.11 | 6.1e-01 | Click! |
| FEV | hg19_v2_chr2_-_219850277_219850379 | 0.11 | 6.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_71185148 Show fit | 7.07 |
ENST00000443425.2
ENST00000560755.1 |
leucine rich repeat containing 49 |
|
| chr15_+_71184931 Show fit | 6.91 |
ENST00000560369.1
ENST00000260382.5 |
leucine rich repeat containing 49 |
|
| chr9_-_123691439 Show fit | 5.80 |
ENST00000540010.1
|
TNF receptor-associated factor 1 |
|
| chr9_-_123691047 Show fit | 5.66 |
ENST00000373887.3
|
TNF receptor-associated factor 1 |
|
| chr16_+_31044812 Show fit | 5.13 |
ENST00000313843.3
|
syntaxin 4 |
|
| chr20_-_48532046 Show fit | 4.52 |
ENST00000543716.1
|
spermatogenesis associated 2 |
|
| chr7_+_108210012 Show fit | 4.18 |
ENST00000249356.3
|
DnaJ (Hsp40) homolog, subfamily B, member 9 |
|
| chr2_+_103035102 Show fit | 4.08 |
ENST00000264260.2
|
interleukin 18 receptor accessory protein |
|
| chr1_-_173174681 Show fit | 3.73 |
ENST00000367718.1
|
tumor necrosis factor (ligand) superfamily, member 4 |
|
| chr8_-_37756972 Show fit | 3.67 |
ENST00000330843.4
ENST00000522727.1 ENST00000287263.4 |
RAB11 family interacting protein 1 (class I) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV1_ERF_FEV_ELF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 14.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.2 | 8.7 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 2.8 | 8.3 | GO:1902568 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.2 | 7.5 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.3 | 6.9 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 2.1 | 6.3 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
| 0.3 | 6.2 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.3 | 6.0 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.1 | 5.9 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.3 | 9.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 8.4 | GO:0016605 | PML body(GO:0016605) |
| 0.8 | 8.3 | GO:0000322 | storage vacuole(GO:0000322) |
| 1.0 | 8.1 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.1 | 7.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 7.0 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.2 | 7.0 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.0 | 6.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 6.1 | GO:0030127 | COPII vesicle coat(GO:0030127) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.8 | 13.3 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.2 | 12.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.5 | 9.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 2.1 | 8.3 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.1 | 6.8 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 6.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.2 | 6.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 6.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 6.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 9.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 8.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 8.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 7.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 5.8 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 5.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 5.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 5.1 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 4.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.2 | 14.0 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.1 | 11.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 10.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 6.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 6.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 6.1 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 5.3 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 5.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 4.7 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |