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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ETV3
Z-value: 1.22
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Transcription factors associated with ETV3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV3 | hg19_v2_chr1_-_157108130_157108173 | -0.29 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.2 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.2 | 8.1 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.2 | 6.8 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 2.1 | 6.2 | GO:0032888 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.8 | 4.2 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.2 | 3.6 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.1 | 3.5 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.1 | 3.5 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 3.5 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.1 | 3.4 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 17.2 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 6.8 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 6.6 | GO:0002102 | podosome(GO:0002102) |
| 2.1 | 6.2 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.0 | 5.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 3.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.0 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 2.6 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 2.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 2.4 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 17.2 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.3 | 8.1 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 7.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.5 | 6.9 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.2 | 3.5 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 3.5 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 3.5 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 1.1 | 3.3 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
| 0.3 | 3.1 | GO:0071253 | connexin binding(GO:0071253) |
| 0.6 | 2.9 | GO:0032810 | sterol response element binding(GO:0032810) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 1.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.4 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.3 | PID INSULIN PATHWAY | Insulin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.2 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.2 | 7.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 6.2 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 4.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 4.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 4.3 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.0 | 4.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 3.6 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 3.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 2.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |