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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ETV7
Z-value: 0.93
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Transcription factors associated with ETV7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV7 | hg19_v2_chr6_-_36355513_36355578 | 0.39 | 5.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_79816965 Show fit | 1.46 |
ENST00000464233.1
|
roundabout, axon guidance receptor, homolog 1 (Drosophila) |
|
| chr5_-_150466692 Show fit | 1.10 |
ENST00000315050.7
ENST00000523338.1 ENST00000522100.1 |
TNFAIP3 interacting protein 1 |
|
| chr12_+_52626898 Show fit | 1.01 |
ENST00000331817.5
|
keratin 7 |
|
| chr10_-_90712520 Show fit | 0.93 |
ENST00000224784.6
|
actin, alpha 2, smooth muscle, aorta |
|
| chr19_-_50370799 Show fit | 0.86 |
ENST00000600910.1
ENST00000322344.3 ENST00000600573.1 |
polynucleotide kinase 3'-phosphatase |
|
| chr15_-_80263506 Show fit | 0.76 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr18_+_72167096 Show fit | 0.75 |
ENST00000324301.8
|
CNDP dipeptidase 2 (metallopeptidase M20 family) |
|
| chr12_+_20968608 Show fit | 0.74 |
ENST00000381541.3
ENST00000540229.1 ENST00000553473.1 ENST00000554957.1 |
Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein solute carrier organic anion transporter family, member 1B3 solute carrier organic anion transporter family, member 1B7 (non-functional) |
|
| chr17_+_39388700 Show fit | 0.71 |
ENST00000411528.2
|
keratin associated protein 9-3 |
|
| chr16_-_4401284 Show fit | 0.71 |
ENST00000318059.3
|
presequence translocase-associated motor 16 homolog (S. cerevisiae) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0021823 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) |
| 0.0 | 1.5 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.4 | 1.4 | GO:0052027 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.2 | 1.3 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.0 | 1.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.4 | 1.2 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 0.2 | 1.2 | GO:0098502 | DNA dephosphorylation(GO:0098502) |
| 0.1 | 1.1 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.1 | 1.1 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 1.0 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.6 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 1.4 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 1.0 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.2 | 1.0 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.2 | 0.9 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.9 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.9 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.2 | 0.8 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.1 | 0.8 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.5 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 1.3 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.3 | 1.2 | GO:0051733 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518) |
| 0.2 | 1.2 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.4 | 1.1 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.0 | 1.1 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.1 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.2 | 0.9 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.2 | 0.9 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.0 | 0.9 | GO:0097602 | cullin family protein binding(GO:0097602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.5 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.5 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 1.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.8 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |