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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for EVX2
Z-value: 0.32
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Transcription factors associated with EVX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
EVX2
|
ENSG00000174279.4 | even-skipped homeobox 2 |
Activity profile of EVX2 motif
Sorted Z-values of EVX2 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_55562479 | 0.64 |
ENST00000564609.1
|
RAB27A
|
RAB27A, member RAS oncogene family |
| chr15_-_55563072 | 0.60 |
ENST00000567380.1
ENST00000565972.1 ENST00000569493.1 |
RAB27A
|
RAB27A, member RAS oncogene family |
| chr15_-_55562582 | 0.59 |
ENST00000396307.2
|
RAB27A
|
RAB27A, member RAS oncogene family |
| chr3_+_111717511 | 0.44 |
ENST00000478951.1
ENST00000393917.2 |
TAGLN3
|
transgelin 3 |
| chr3_+_111717600 | 0.43 |
ENST00000273368.4
|
TAGLN3
|
transgelin 3 |
| chr18_-_33709268 | 0.41 |
ENST00000269187.5
ENST00000590986.1 ENST00000440549.2 |
SLC39A6
|
solute carrier family 39 (zinc transporter), member 6 |
| chr3_+_111718036 | 0.39 |
ENST00000455401.2
|
TAGLN3
|
transgelin 3 |
| chr4_+_144354644 | 0.36 |
ENST00000512843.1
|
GAB1
|
GRB2-associated binding protein 1 |
| chr6_-_62996066 | 0.31 |
ENST00000281156.4
|
KHDRBS2
|
KH domain containing, RNA binding, signal transduction associated 2 |
| chr20_-_50419055 | 0.26 |
ENST00000217086.4
|
SALL4
|
spalt-like transcription factor 4 |
| chr1_+_160160283 | 0.24 |
ENST00000368079.3
|
CASQ1
|
calsequestrin 1 (fast-twitch, skeletal muscle) |
| chr1_+_160160346 | 0.24 |
ENST00000368078.3
|
CASQ1
|
calsequestrin 1 (fast-twitch, skeletal muscle) |
| chr20_-_50418972 | 0.23 |
ENST00000395997.3
|
SALL4
|
spalt-like transcription factor 4 |
| chr3_+_111718173 | 0.22 |
ENST00000494932.1
|
TAGLN3
|
transgelin 3 |
| chr20_-_50418947 | 0.22 |
ENST00000371539.3
|
SALL4
|
spalt-like transcription factor 4 |
| chr1_+_28261533 | 0.13 |
ENST00000411604.1
ENST00000373888.4 |
SMPDL3B
|
sphingomyelin phosphodiesterase, acid-like 3B |
| chr1_+_28261621 | 0.13 |
ENST00000549094.1
|
SMPDL3B
|
sphingomyelin phosphodiesterase, acid-like 3B |
| chr1_+_28261492 | 0.13 |
ENST00000373894.3
|
SMPDL3B
|
sphingomyelin phosphodiesterase, acid-like 3B |
| chr20_+_43990576 | 0.10 |
ENST00000372727.1
ENST00000414310.1 |
SYS1
|
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) |
| chr4_-_41884620 | 0.10 |
ENST00000504870.1
|
LINC00682
|
long intergenic non-protein coding RNA 682 |
| chr12_+_15699286 | 0.08 |
ENST00000442921.2
ENST00000542557.1 ENST00000445537.2 ENST00000544244.1 |
PTPRO
|
protein tyrosine phosphatase, receptor type, O |
| chr11_+_65554493 | 0.07 |
ENST00000335987.3
|
OVOL1
|
ovo-like zinc finger 1 |
| chr20_+_30467600 | 0.05 |
ENST00000375934.4
ENST00000375922.4 |
TTLL9
|
tubulin tyrosine ligase-like family, member 9 |
| chr8_+_92261516 | 0.05 |
ENST00000276609.3
ENST00000309536.2 |
SLC26A7
|
solute carrier family 26 (anion exchanger), member 7 |
| chr17_-_27418537 | 0.04 |
ENST00000408971.2
|
TIAF1
|
TGFB1-induced anti-apoptotic factor 1 |
| chr3_+_115342349 | 0.03 |
ENST00000393780.3
|
GAP43
|
growth associated protein 43 |
| chr11_-_115375107 | 0.01 |
ENST00000545380.1
ENST00000452722.3 ENST00000537058.1 ENST00000536727.1 ENST00000542447.2 ENST00000331581.6 |
CADM1
|
cell adhesion molecule 1 |
| chr17_-_9929581 | 0.01 |
ENST00000437099.2
ENST00000396115.2 |
GAS7
|
growth arrest-specific 7 |
| chr4_-_41884582 | 0.00 |
ENST00000499082.2
|
LINC00682
|
long intergenic non-protein coding RNA 682 |
| chr5_-_96478466 | 0.00 |
ENST00000274382.4
|
LIX1
|
Lix1 homolog (chicken) |
Network of associatons between targets according to the STRING database.
First level regulatory network of EVX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.8 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.0 | 0.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.5 | GO:0014894 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.0 | 0.4 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.1 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 0.0 | 0.1 | GO:0044771 | meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) |
| 0.0 | 0.4 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.5 | GO:0014802 | terminal cisterna(GO:0014802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.4 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.3 | GO:0008143 | poly(A) binding(GO:0008143) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.4 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |