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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for EZH2
Z-value: 1.13
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Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg19_v2_chr7_-_148581251_148581347 | 0.48 | 1.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_72441315 Show fit | 8.68 |
ENST00000305425.4
ENST00000313174.7 ENST00000354591.4 |
dachshund homolog 1 (Drosophila) |
|
| chr4_-_16900242 Show fit | 6.40 |
ENST00000502640.1
ENST00000506732.1 |
LIM domain binding 2 |
|
| chr4_+_156588249 Show fit | 6.39 |
ENST00000393832.3
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_-_16900184 Show fit | 5.86 |
ENST00000515064.1
|
LIM domain binding 2 |
|
| chr4_-_16900217 Show fit | 5.67 |
ENST00000441778.2
|
LIM domain binding 2 |
|
| chr4_-_16900410 Show fit | 4.71 |
ENST00000304523.5
|
LIM domain binding 2 |
|
| chr4_+_156588115 Show fit | 4.70 |
ENST00000455639.2
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr5_+_175298573 Show fit | 3.74 |
ENST00000512824.1
|
complexin 2 |
|
| chr13_-_72440901 Show fit | 3.38 |
ENST00000359684.2
|
dachshund homolog 1 (Drosophila) |
|
| chr14_-_54423529 Show fit | 3.00 |
ENST00000245451.4
ENST00000559087.1 |
bone morphogenetic protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 23.2 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 2.6 | 15.8 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 1.5 | 12.1 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.3 | 7.7 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 1.0 | 4.1 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.2 | 4.0 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 3.5 | GO:0043586 | tongue development(GO:0043586) |
| 1.0 | 3.0 | GO:2000006 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 1.0 | 2.9 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.7 | 2.7 | GO:1903597 | negative regulation of gap junction assembly(GO:1903597) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.6 | 16.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 1.0 | 7.7 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.6 | 2.9 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 2.5 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 2.3 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 2.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 2.1 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 2.0 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.3 | 1.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 22.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.6 | 16.0 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.7 | 12.2 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.3 | 7.9 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 7.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 4.3 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.5 | 2.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 2.8 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.5 | 2.7 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.4 | 2.5 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 6.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.6 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 3.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 3.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 3.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.8 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 2.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.7 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 5.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 4.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 4.3 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 2.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 2.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 2.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 2.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 2.0 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 2.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |