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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FIGLA
Z-value: 0.76
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Transcription factors associated with FIGLA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FIGLA | hg19_v2_chr2_-_71017775_71017775 | -0.28 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_39382900 Show fit | 20.18 |
ENST00000377721.3
ENST00000455970.2 |
keratin associated protein 9-2 |
|
| chr17_+_39394250 Show fit | 5.56 |
ENST00000254072.6
|
keratin associated protein 9-8 |
|
| chr1_+_61542922 Show fit | 2.25 |
ENST00000407417.3
|
nuclear factor I/A |
|
| chr7_-_120497178 Show fit | 2.02 |
ENST00000441017.1
ENST00000424710.1 ENST00000433758.1 |
tetraspanin 12 |
|
| chr7_-_11871815 Show fit | 1.92 |
ENST00000423059.4
|
thrombospondin, type I, domain containing 7A |
|
| chr8_-_80993010 Show fit | 1.86 |
ENST00000537855.1
ENST00000520527.1 ENST00000517427.1 ENST00000448733.2 ENST00000379097.3 |
tumor protein D52 |
|
| chr11_-_33913708 Show fit | 1.75 |
ENST00000257818.2
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr5_+_68788594 Show fit | 1.74 |
ENST00000396442.2
ENST00000380766.2 |
occludin |
|
| chr7_+_12727250 Show fit | 1.65 |
ENST00000404894.1
|
ADP-ribosylation factor-like 4A |
|
| chr9_+_90112767 Show fit | 1.33 |
ENST00000408954.3
|
death-associated protein kinase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FIGLA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.1 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 2.8 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.8 | 2.3 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 2.2 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 2.2 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 2.0 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 1.8 | GO:0042789 | mRNA transcription from RNA polymerase II promoter(GO:0042789) |
| 0.1 | 1.7 | GO:0070673 | response to interleukin-18(GO:0070673) |
| 0.0 | 1.7 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.3 | 1.3 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 2.8 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.5 | 2.3 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 1.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 1.1 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 1.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.0 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 1.0 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.9 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.4 | 2.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 2.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 2.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.5 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 1.4 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.0 | 1.2 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.3 | 1.1 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 1.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 2.0 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 1.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.1 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 2.0 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 1.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.0 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |