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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FLI1
Z-value: 0.92
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Transcription factors associated with FLI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FLI1 | hg19_v2_chr11_+_128563652_128563689, hg19_v2_chr11_+_128563948_128564003, hg19_v2_chr11_+_128634589_128634685 | 0.59 | 2.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FLI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.6 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.8 | 5.3 | GO:0032888 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.6 | 3.9 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.6 | 3.9 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.1 | 3.9 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.2 | 3.2 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 0.2 | 2.7 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.2 | 2.7 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 2.7 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.1 | 2.5 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 5.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 1.8 | 5.3 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.7 | 4.3 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.2 | 4.2 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 1.0 | 4.0 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.0 | 3.1 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 2.6 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 2.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 2.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 11.1 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 6.1 | GO:0005525 | GTP binding(GO:0005525) |
| 0.4 | 5.5 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.7 | 4.3 | GO:0003920 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.4 | 4.0 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.2 | 3.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 2.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 2.3 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 2.2 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 2.1 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 3.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 2.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 2.2 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 5.2 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.3 | 5.1 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.2 | 3.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 2.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 2.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.0 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 1.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.5 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.4 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |