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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FOSL1
Z-value: 1.00
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Transcription factors associated with FOSL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667997_65668044 | 0.80 | 1.4e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_183155373 Show fit | 7.05 |
ENST00000493293.1
ENST00000264144.4 |
laminin, gamma 2 |
|
| chr15_+_89182178 Show fit | 7.05 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89182156 Show fit | 6.92 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr11_-_102668879 Show fit | 6.59 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr2_+_152214098 Show fit | 6.35 |
ENST00000243347.3
|
tumor necrosis factor, alpha-induced protein 6 |
|
| chr21_+_26934165 Show fit | 6.23 |
ENST00000456917.1
|
MIR155 host gene (non-protein coding) |
|
| chr4_+_74606223 Show fit | 6.22 |
ENST00000307407.3
ENST00000401931.1 |
interleukin 8 |
|
| chr15_+_89181974 Show fit | 6.12 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr1_-_153521597 Show fit | 5.69 |
ENST00000368712.1
|
S100 calcium binding protein A3 |
|
| chr1_-_153521714 Show fit | 5.07 |
ENST00000368713.3
|
S100 calcium binding protein A3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 20.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 9.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 6.4 | GO:0030728 | ovulation(GO:0030728) |
| 1.2 | 5.8 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.4 | 5.3 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 5.3 | GO:0043486 | histone exchange(GO:0043486) |
| 1.6 | 4.7 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 1.2 | 4.7 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.8 | 4.7 | GO:2001180 | negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183) |
| 0.6 | 4.6 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 13.8 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 10.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 6.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 6.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 2.0 | 6.1 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.6 | 5.8 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 5.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.3 | 5.3 | GO:0000812 | Swr1 complex(GO:0000812) |
| 1.6 | 4.7 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 20.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 17.2 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.3 | 10.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 7.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 6.3 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 5.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 5.6 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.9 | 4.7 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 4.7 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 1.5 | 4.4 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 10.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 9.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 8.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 8.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 7.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 6.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 4.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.2 | 4.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 10.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 6.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 6.6 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 5.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 5.7 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 5.1 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 4.7 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 4.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 4.6 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |