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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FOSL2_SMARCC1
Z-value: 0.79
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Transcription factors associated with FOSL2_SMARCC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000075426.7 | FOS like 2, AP-1 transcription factor subunit | |
| ENSG00000173473.6 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL2 | hg19_v2_chr2_+_28615669_28615733 | 0.34 | 9.3e-02 | Click! |
| SMARCC1 | hg19_v2_chr3_-_47823298_47823423 | 0.27 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_74606223 Show fit | 3.58 |
ENST00000307407.3
ENST00000401931.1 |
interleukin 8 |
|
| chr7_+_30960915 Show fit | 2.87 |
ENST00000441328.2
ENST00000409899.1 ENST00000409611.1 |
aquaporin 1 (Colton blood group) |
|
| chr12_-_49259643 Show fit | 2.37 |
ENST00000309739.5
|
Rho family GTPase 1 |
|
| chr13_+_32838801 Show fit | 2.13 |
ENST00000542859.1
|
furry homolog (Drosophila) |
|
| chr15_+_67420441 Show fit | 2.05 |
ENST00000558894.1
|
SMAD family member 3 |
|
| chr15_+_67458357 Show fit | 1.83 |
ENST00000537194.2
|
SMAD family member 3 |
|
| chr10_+_104155450 Show fit | 1.81 |
ENST00000471698.1
ENST00000189444.6 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
|
| chr21_+_26934165 Show fit | 1.73 |
ENST00000456917.1
|
MIR155 host gene (non-protein coding) |
|
| chr3_+_11178779 Show fit | 1.71 |
ENST00000438284.2
|
histamine receptor H1 |
|
| chr15_+_67418047 Show fit | 1.43 |
ENST00000540846.2
|
SMAD family member 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL2_SMARCC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.3 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 1.0 | 2.9 | GO:0072019 | carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 0.2 | 2.7 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.2 | 2.6 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.2 | 2.3 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.3 | 2.1 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.2 | 1.9 | GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.0 | 1.9 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.5 | 1.8 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.4 | 1.8 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.3 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 4.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.0 | 2.9 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 2.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 2.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 1.9 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.5 | 1.8 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 1.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.2 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 1.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.3 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 4.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.0 | 2.9 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.2 | 2.7 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.6 | 1.8 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.2 | 1.7 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 1.7 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 1.7 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.3 | 1.5 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.0 | 1.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 4.9 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 3.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 3.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 3.6 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.2 | 2.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.5 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 2.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 1.7 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 1.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 1.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |