Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for FOXD3_FOXI1_FOXF1
Z-value: 0.99
Motif logo
Transcription factors associated with FOXD3_FOXI1_FOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXF1 | hg19_v2_chr16_+_86544113_86544145 | 0.54 | 5.6e-03 | Click! |
| FOXD3 | hg19_v2_chr1_+_63788730_63788730 | 0.29 | 1.6e-01 | Click! |
| FOXI1 | hg19_v2_chr5_+_169532896_169532917 | 0.09 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_89182156 Show fit | 3.98 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89182178 Show fit | 3.88 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89181974 Show fit | 3.24 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr11_-_108464465 Show fit | 3.12 |
ENST00000525344.1
|
exophilin 5 |
|
| chr3_-_127455200 Show fit | 2.51 |
ENST00000398101.3
|
monoglyceride lipase |
|
| chr17_+_74372662 Show fit | 2.49 |
ENST00000591651.1
ENST00000545180.1 |
sphingosine kinase 1 |
|
| chr8_+_120079478 Show fit | 2.22 |
ENST00000332843.2
|
collectin sub-family member 10 (C-type lectin) |
|
| chr2_+_152214098 Show fit | 2.22 |
ENST00000243347.3
|
tumor necrosis factor, alpha-induced protein 6 |
|
| chr4_+_89299994 Show fit | 2.07 |
ENST00000264346.7
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr4_+_89299885 Show fit | 2.04 |
ENST00000380265.5
ENST00000273960.3 |
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD3_FOXI1_FOXF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 11.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.0 | 5.0 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.2 | 4.2 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.6 | 4.1 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.0 | 3.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.3 | 3.3 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.4 | 2.6 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.8 | 2.5 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.0 | 2.5 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.4 | 2.4 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 7.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 4.7 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 3.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.7 | 2.7 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 2.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 2.4 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 1.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 1.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 1.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 11.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 4.8 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.2 | 4.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 3.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 3.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 3.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.7 | 3.3 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.0 | 3.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 3.0 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 2.8 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.8 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 2.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 2.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 1.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.3 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 3.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 3.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 2.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 2.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 2.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |