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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 1.23
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000164916.9 | forkhead box K1 | |
| ENSG00000128573.18 | forkhead box P2 | |
| ENSG00000171956.5 | forkhead box B1 | |
| ENSG00000049768.10 | forkhead box P3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP2 | hg19_v2_chr7_+_114055052_114055378 | 0.42 | 3.6e-02 | Click! |
| FOXK1 | hg19_v2_chr7_+_4721885_4721945 | -0.37 | 6.6e-02 | Click! |
| FOXB1 | hg19_v2_chr15_+_60296421_60296464 | -0.25 | 2.3e-01 | Click! |
| FOXP3 | hg19_v2_chrX_-_49121165_49121288 | 0.18 | 4.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 19.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 18.5 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.2 | 8.0 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.4 | 7.1 | GO:0045074 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.1 | 6.9 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.1 | 6.5 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.6 | 6.3 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.2 | 6.0 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 6.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 5.8 | GO:1901222 | regulation of NIK/NF-kappaB signaling(GO:1901222) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 20.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 15.6 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.3 | 9.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 9.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 7.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 6.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 6.1 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.2 | 5.3 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 4.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.5 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 19.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 1.1 | 14.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.4 | 10.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 8.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 6.9 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 6.1 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 1.9 | 5.8 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.0 | 5.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 5.2 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.2 | 5.1 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 19.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 14.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 6.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 6.6 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 6.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 5.4 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.2 | 5.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 5.0 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 19.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 17.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 9.3 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 8.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.4 | 7.8 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.2 | 6.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.3 | 6.7 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 5.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.3 | 5.4 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 5.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |