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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FOXL1
Z-value: 1.71
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Transcription factors associated with FOXL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXL1 | hg19_v2_chr16_+_86612112_86612123 | -0.10 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_8543393 Show fit | 32.36 |
ENST00000157600.3
ENST00000415597.1 ENST00000535732.1 |
LIM and cysteine-rich domains 1 |
|
| chr3_+_8543533 Show fit | 21.96 |
ENST00000454244.1
|
LIM and cysteine-rich domains 1 |
|
| chr3_+_8543561 Show fit | 20.35 |
ENST00000397386.3
|
LIM and cysteine-rich domains 1 |
|
| chr4_+_41540160 Show fit | 10.72 |
ENST00000503057.1
ENST00000511496.1 |
LIM and calponin homology domains 1 |
|
| chr5_-_43043272 Show fit | 7.45 |
ENST00000314890.3
|
annexin A2 receptor |
|
| chr9_-_47314222 Show fit | 7.32 |
ENST00000420228.1
ENST00000438517.1 ENST00000414020.1 |
AL953854.2 |
|
| chr1_+_84630645 Show fit | 6.95 |
ENST00000394839.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr4_-_186877806 Show fit | 6.77 |
ENST00000355634.5
|
sorbin and SH3 domain containing 2 |
|
| chr6_+_116832789 Show fit | 5.30 |
ENST00000368599.3
|
family with sequence similarity 26, member E |
|
| chr11_+_71238313 Show fit | 4.91 |
ENST00000398536.4
|
keratin associated protein 5-7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 74.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 2.0 | 13.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 11.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 10.8 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.3 | 9.8 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 9.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 8.2 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 6.5 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.3 | 5.3 | GO:0015871 | choline transport(GO:0015871) |
| 0.7 | 4.9 | GO:0072564 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 57.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.7 | 15.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 11.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 7.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 7.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 6.5 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.2 | 5.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 5.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 4.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 4.2 | GO:0042641 | actomyosin(GO:0042641) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 74.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.8 | 13.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.7 | 10.8 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.4 | 10.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.4 | 8.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 6.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 5.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 5.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 5.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.6 | 5.3 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 9.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 7.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 7.3 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 7.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 5.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.3 | 4.6 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 3.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.4 | 14.6 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 8.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 6.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.2 | 5.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 4.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 4.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 4.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.3 | 4.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 4.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |