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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FOXM1_TBL1XR1
Z-value: 1.08
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Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXM1 | hg19_v2_chr12_-_2986107_2986258 | 0.33 | 1.1e-01 | Click! |
| TBL1XR1 | hg19_v2_chr3_-_176914238_176914277 | 0.23 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76957214 Show fit | 1.62 |
ENST00000306621.3
|
chemokine (C-X-C motif) ligand 11 |
|
| chr3_+_29322437 Show fit | 1.62 |
ENST00000434693.2
|
RNA binding motif, single stranded interacting protein 3 |
|
| chr1_+_79086088 Show fit | 1.60 |
ENST00000370751.5
ENST00000342282.3 |
interferon-induced protein 44-like |
|
| chr10_+_91152303 Show fit | 1.47 |
ENST00000371804.3
|
interferon-induced protein with tetratricopeptide repeats 1 |
|
| chr3_-_127455200 Show fit | 1.45 |
ENST00000398101.3
|
monoglyceride lipase |
|
| chr4_-_76944621 Show fit | 1.45 |
ENST00000306602.1
|
chemokine (C-X-C motif) ligand 10 |
|
| chr6_-_29527702 Show fit | 1.41 |
ENST00000377050.4
|
ubiquitin D |
|
| chr10_+_91092241 Show fit | 1.38 |
ENST00000371811.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr19_-_6690723 Show fit | 1.31 |
ENST00000601008.1
|
complement component 3 |
|
| chr14_+_22748980 Show fit | 1.27 |
ENST00000390465.2
|
T cell receptor alpha variable 38-2/delta variable 8 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 3.7 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.0 | 3.1 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 0.0 | 2.8 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.3 | 2.4 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.3 | 2.3 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) |
| 0.6 | 2.2 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 0.2 | 2.0 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.1 | 2.0 | GO:0060088 | auditory receptor cell stereocilium organization(GO:0060088) |
| 0.2 | 1.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 3.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 3.0 | GO:0070160 | occluding junction(GO:0070160) |
| 0.3 | 2.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 1.6 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 1.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 1.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 1.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 1.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.3 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 4.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 3.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 3.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.7 | 3.4 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 3.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 2.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 2.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 2.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 2.5 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 1.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 6.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 3.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.8 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 2.6 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 2.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 2.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 2.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 2.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 1.9 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |