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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for FOXO3_FOXD2

Z-value: 0.59

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Transcription factors associated with FOXO3_FOXD2

Gene Symbol Gene ID Gene Info
FOXO3
ENSG00000118689.10 forkhead box O3
FOXD2
ENSG00000186564.5 forkhead box D2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXO3hg19_v2_chr6_+_108882069_108882087,
hg19_v2_chr6_+_108881012_108881038		0.663.2e-04Click!
FOXD2hg19_v2_chr1_+_47901689_479016890.471.7e-02Click!

Activity profile of FOXO3_FOXD2 motif

Sorted Z-values of FOXO3_FOXD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_57408994 1.65 ENST00000312655.4
YPEL2
yippee-like 2 (Drosophila)
chr6_-_31550192 1.49 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr3_-_71179988 1.40 ENST00000491238.1
FOXP1
forkhead box P1
chr4_+_74606223 1.34 ENST00000307407.3
ENST00000401931.1
IL8
interleukin 8
chr8_+_31497271 1.32 ENST00000520407.1
NRG1
neuregulin 1
chr10_-_45474237 1.27 ENST00000448778.1
ENST00000298295.3
C10orf10
chromosome 10 open reading frame 10
chr3_-_71179699 1.17 ENST00000497355.1
FOXP1
forkhead box P1
chr17_+_26662597 1.16 ENST00000544907.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr17_-_61777090 1.12 ENST00000578061.1
LIMD2
LIM domain containing 2
chr1_-_12677714 1.05 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr5_-_38557561 1.04 ENST00000511561.1
LIFR
leukemia inhibitory factor receptor alpha
chr8_+_120079478 0.96 ENST00000332843.2
COLEC10
collectin sub-family member 10 (C-type lectin)
chr3_-_71294304 0.95 ENST00000498215.1
FOXP1
forkhead box P1
chr17_+_26662730 0.94 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr7_+_134551583 0.94 ENST00000435928.1
CALD1
caldesmon 1
chr7_+_134832808 0.91 ENST00000275767.3
TMEM140
transmembrane protein 140
chr8_-_119124045 0.90 ENST00000378204.2
EXT1
exostosin glycosyltransferase 1
chr5_-_150460914 0.89 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr3_+_46449049 0.89 ENST00000357392.4
ENST00000400880.3
ENST00000433848.1
CCRL2
chemokine (C-C motif) receptor-like 2
chr5_-_150460539 0.86 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNIP1
TNFAIP3 interacting protein 1
chr1_-_201096312 0.86 ENST00000449188.2
ASCL5
achaete-scute family bHLH transcription factor 5
chr18_+_3449330 0.83 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr16_-_57831914 0.82 ENST00000421376.2
KIFC3
kinesin family member C3
chr2_+_161993465 0.78 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr2_+_111878483 0.78 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2L11
BCL2-like 11 (apoptosis facilitator)
chr5_-_142783175 0.75 ENST00000231509.3
ENST00000394464.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_13906250 0.72 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr12_-_71551652 0.71 ENST00000546561.1
TSPAN8
tetraspanin 8
chr11_-_72070206 0.69 ENST00000544382.1
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr11_+_117049910 0.69 ENST00000431081.2
ENST00000524842.1
SIDT2
SID1 transmembrane family, member 2
chrX_+_9431324 0.68 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr7_-_99698338 0.61 ENST00000354230.3
ENST00000425308.1
MCM7
minichromosome maintenance complex component 7
chr1_-_161102367 0.60 ENST00000464113.1
DEDD
death effector domain containing
chr11_-_108464465 0.59 ENST00000525344.1
EXPH5
exophilin 5
chr11_+_34643600 0.59 ENST00000530286.1
ENST00000533754.1
EHF
ets homologous factor
chr5_-_16742330 0.58 ENST00000505695.1
ENST00000427430.2
MYO10
myosin X
chr2_+_162087577 0.58 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr6_+_135502408 0.58 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr6_+_135502466 0.58 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr6_-_87804815 0.57 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr8_+_86121448 0.57 ENST00000520225.1
E2F5
E2F transcription factor 5, p130-binding
chr6_+_108977520 0.56 ENST00000540898.1
FOXO3
forkhead box O3
chr1_-_161102421 0.56 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr1_-_161102213 0.56 ENST00000458050.2
DEDD
death effector domain containing
chr5_-_142782862 0.52 ENST00000415690.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr10_-_101841588 0.52 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr18_+_60382672 0.49 ENST00000400316.4
ENST00000262719.5
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr10_+_123923105 0.49 ENST00000368999.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr15_+_28624878 0.48 ENST00000450328.2
GOLGA8F
golgin A8 family, member F
chr11_-_102651343 0.48 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr9_+_118916082 0.48 ENST00000328252.3
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr21_-_35899113 0.47 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr1_+_86934526 0.47 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr2_-_136875712 0.47 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr2_+_201981527 0.46 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr8_+_104384616 0.45 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr18_+_57567180 0.45 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_-_47734448 0.45 ENST00000439096.2
BBC3
BCL2 binding component 3
chr13_+_97874574 0.44 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
MBNL2
muscleblind-like splicing regulator 2
chr1_-_27816556 0.44 ENST00000536657.1
WASF2
WAS protein family, member 2
chr10_+_123922941 0.44 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr3_-_107777208 0.42 ENST00000398258.3
CD47
CD47 molecule
chr11_-_34535332 0.42 ENST00000257832.2
ENST00000429939.2
ELF5
E74-like factor 5 (ets domain transcription factor)
chr2_+_161993412 0.41 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr5_+_149980622 0.41 ENST00000394243.1
SYNPO
synaptopodin
chr17_-_39150385 0.40 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr2_+_150187020 0.40 ENST00000334166.4
LYPD6
LY6/PLAUR domain containing 6
chr6_-_89927151 0.40 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr4_-_139163491 0.39 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr18_+_61575200 0.39 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr6_+_135502501 0.39 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr10_+_123923205 0.39 ENST00000369004.3
ENST00000260733.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr15_-_55541227 0.38 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr18_+_66465302 0.38 ENST00000360242.5
ENST00000358653.5
CCDC102B
coiled-coil domain containing 102B
chr10_+_114710425 0.38 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr10_-_13570533 0.37 ENST00000396900.2
ENST00000396898.2
BEND7
BEN domain containing 7
chr2_+_152266604 0.37 ENST00000430328.2
RIF1
RAP1 interacting factor homolog (yeast)
chr8_-_101321584 0.37 ENST00000523167.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr6_+_108882069 0.37 ENST00000406360.1
FOXO3
forkhead box O3
chrX_-_108725301 0.37 ENST00000218006.2
GUCY2F
guanylate cyclase 2F, retinal
chr1_+_209878182 0.37 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_-_71551868 0.37 ENST00000247829.3
TSPAN8
tetraspanin 8
chr2_+_152266392 0.37 ENST00000444746.2
ENST00000453091.2
ENST00000428287.2
ENST00000433166.2
ENST00000420714.3
ENST00000243326.5
ENST00000414861.2
RIF1
RAP1 interacting factor homolog (yeast)
chr1_-_26394114 0.37 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr13_-_39564993 0.36 ENST00000423210.1
STOML3
stomatin (EPB72)-like 3
chr2_+_175260514 0.36 ENST00000424069.1
ENST00000427038.1
SCRN3
secernin 3
chr14_-_73493784 0.36 ENST00000553891.1
ZFYVE1
zinc finger, FYVE domain containing 1
chr14_-_76447494 0.36 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr17_+_57642886 0.35 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr7_+_28725585 0.35 ENST00000396298.2
CREB5
cAMP responsive element binding protein 5
chr12_-_772901 0.35 ENST00000305108.4
NINJ2
ninjurin 2
chr18_+_77160282 0.35 ENST00000318065.5
ENST00000545796.1
ENST00000592223.1
ENST00000329101.4
ENST00000586434.1
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr18_+_55816546 0.35 ENST00000435432.2
ENST00000357895.5
ENST00000586263.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr17_+_56232494 0.34 ENST00000268912.5
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr1_-_160231451 0.34 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr12_-_53074182 0.34 ENST00000252244.3
KRT1
keratin 1
chr8_+_99956759 0.34 ENST00000522510.1
ENST00000457907.2
OSR2
odd-skipped related transciption factor 2
chr14_+_102276192 0.33 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr11_+_33061543 0.33 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr11_-_107582775 0.33 ENST00000305991.2
SLN
sarcolipin
chr11_-_72504681 0.33 ENST00000538536.1
ENST00000543304.1
ENST00000540587.1
ENST00000334805.6
STARD10
StAR-related lipid transfer (START) domain containing 10
chr17_+_74372662 0.32 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr14_-_73493825 0.32 ENST00000318876.5
ENST00000556143.1
ZFYVE1
zinc finger, FYVE domain containing 1
chr11_+_34654011 0.32 ENST00000531794.1
EHF
ets homologous factor
chr17_+_41561317 0.31 ENST00000540306.1
ENST00000262415.3
ENST00000605777.1
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr17_+_65374075 0.31 ENST00000581322.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr17_-_30185946 0.31 ENST00000579741.1
COPRS
coordinator of PRMT5, differentiation stimulator
chr3_+_9691117 0.31 ENST00000353332.5
ENST00000420925.1
ENST00000296003.4
ENST00000351233.5
MTMR14
myotubularin related protein 14
chr5_-_64920115 0.31 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr13_+_28712614 0.31 ENST00000380958.3
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr2_-_74007193 0.31 ENST00000377706.4
ENST00000443070.1
ENST00000272444.3
DUSP11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr3_+_172468505 0.30 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr2_-_208030647 0.30 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_+_100041527 0.30 ENST00000324341.1
FAM71C
family with sequence similarity 71, member C
chr17_+_74261413 0.30 ENST00000587913.1
UBALD2
UBA-like domain containing 2
chr12_-_31479107 0.30 ENST00000542983.1
FAM60A
family with sequence similarity 60, member A
chr4_-_168155169 0.30 ENST00000534949.1
ENST00000535728.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr16_-_57831676 0.30 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3
kinesin family member C3
chr5_+_133451254 0.29 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr6_-_55739542 0.29 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr9_+_140125385 0.29 ENST00000361134.2
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr10_-_24770632 0.29 ENST00000596413.1
AL353583.1
AL353583.1
chr7_+_134430212 0.29 ENST00000436461.2
CALD1
caldesmon 1
chr3_+_172468472 0.29 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr3_+_148447887 0.29 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr17_-_38721711 0.28 ENST00000578085.1
ENST00000246657.2
CCR7
chemokine (C-C motif) receptor 7
chr3_-_127541194 0.28 ENST00000453507.2
MGLL
monoglyceride lipase
chr1_-_207095324 0.28 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr2_+_197577841 0.28 ENST00000409270.1
CCDC150
coiled-coil domain containing 150
chr9_+_140125209 0.28 ENST00000538474.1
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr8_+_126442563 0.28 ENST00000311922.3
TRIB1
tribbles pseudokinase 1
chr6_+_42847649 0.28 ENST00000424341.2
ENST00000602561.1
RPL7L1
ribosomal protein L7-like 1
chr11_-_85397167 0.27 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr3_+_38347427 0.27 ENST00000273173.4
SLC22A14
solute carrier family 22, member 14
chrX_-_54824673 0.27 ENST00000218436.6
ITIH6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr3_-_141868293 0.27 ENST00000317104.7
ENST00000494358.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_-_146435501 0.27 ENST00000336640.6
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr5_-_146435572 0.27 ENST00000394414.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr2_+_162272605 0.27 ENST00000389554.3
TBR1
T-box, brain, 1
chr8_+_31496809 0.26 ENST00000518104.1
ENST00000519301.1
NRG1
neuregulin 1
chr20_+_55841819 0.26 ENST00000412321.1
ENST00000426580.1
RP4-813D12.3
RP4-813D12.3
chr11_-_107590383 0.26 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr5_-_146435694 0.25 ENST00000356826.3
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr1_-_65432171 0.25 ENST00000342505.4
JAK1
Janus kinase 1
chr6_+_12007897 0.25 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr1_+_74701062 0.25 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr6_+_134758827 0.25 ENST00000431422.1
LINC01010
long intergenic non-protein coding RNA 1010
chr2_-_69098566 0.25 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr22_-_45404819 0.25 ENST00000447824.3
ENST00000404079.2
ENST00000420689.1
ENST00000403565.1
PHF21B
PHD finger protein 21B
chr5_-_36301984 0.24 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L
RAN binding protein 3-like
chr2_-_152146385 0.24 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr12_-_52779433 0.24 ENST00000257951.3
KRT84
keratin 84
chr11_+_20044096 0.24 ENST00000533917.1
NAV2
neuron navigator 2
chr6_+_106546808 0.24 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr1_+_116654376 0.24 ENST00000369500.3
MAB21L3
mab-21-like 3 (C. elegans)
chr10_+_96522361 0.24 ENST00000371321.3
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr2_+_58655461 0.24 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr19_+_41725140 0.23 ENST00000359092.3
AXL
AXL receptor tyrosine kinase
chr6_-_136847099 0.23 ENST00000438100.2
MAP7
microtubule-associated protein 7
chr6_-_88875654 0.23 ENST00000535130.1
CNR1
cannabinoid receptor 1 (brain)
chr10_-_43904608 0.23 ENST00000337970.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr1_-_27240455 0.23 ENST00000254227.3
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr14_-_53331239 0.23 ENST00000553663.1
FERMT2
fermitin family member 2
chr8_-_6420759 0.23 ENST00000523120.1
ANGPT2
angiopoietin 2
chr3_+_46448648 0.23 ENST00000399036.3
CCRL2
chemokine (C-C motif) receptor-like 2
chr19_+_41768561 0.23 ENST00000599719.1
ENST00000601309.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr19_-_7293942 0.23 ENST00000341500.5
ENST00000302850.5
INSR
insulin receptor
chr6_-_159466136 0.22 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr21_-_42219065 0.22 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr6_+_155537771 0.22 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_-_159466042 0.22 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr6_-_136847610 0.22 ENST00000454590.1
ENST00000432797.2
MAP7
microtubule-associated protein 7
chr6_+_72922590 0.22 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_72922505 0.22 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr17_-_46035187 0.22 ENST00000300557.2
PRR15L
proline rich 15-like
chr3_-_27764190 0.22 ENST00000537516.1
EOMES
eomesodermin
chr11_-_114466477 0.22 ENST00000375478.3
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr5_-_13944652 0.22 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr3_-_71632894 0.22 ENST00000493089.1
FOXP1
forkhead box P1
chr3_+_181429704 0.22 ENST00000431565.2
ENST00000325404.1
SOX2
SRY (sex determining region Y)-box 2
chr17_+_65373531 0.22 ENST00000580974.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr22_-_37505588 0.22 ENST00000406856.1
TMPRSS6
transmembrane protease, serine 6
chr20_+_10199468 0.21 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr10_-_3827371 0.21 ENST00000469435.1
KLF6
Kruppel-like factor 6
chr7_+_35756092 0.21 ENST00000458087.3
AC018647.3
AC018647.3
chr6_-_136788001 0.21 ENST00000544465.1
MAP7
microtubule-associated protein 7
chr10_-_103578182 0.21 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr9_+_44867571 0.21 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chr17_-_39140549 0.21 ENST00000377755.4
KRT40
keratin 40
chr7_+_35756186 0.21 ENST00000430518.1
AC018647.3
AC018647.3
chr17_-_49021974 0.21 ENST00000501718.2
RP11-700H6.1
RP11-700H6.1
chr5_+_176853669 0.21 ENST00000355472.5
GRK6
G protein-coupled receptor kinase 6
chr8_-_40755333 0.21 ENST00000297737.6
ENST00000315769.7
ZMAT4
zinc finger, matrin-type 4
chr2_-_121223697 0.20 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr7_-_87342564 0.20 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr14_+_22985251 0.20 ENST00000390510.1
TRAJ27
T cell receptor alpha joining 27
chr17_-_26662440 0.20 ENST00000578122.1
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr11_-_102826434 0.20 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr10_-_99094458 0.20 ENST00000371019.2
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr20_-_50179368 0.19 ENST00000609943.1
ENST00000609507.1
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO3_FOXD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.5 1.5 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.4 1.8 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.3 0.9 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.3 1.8 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 0.8 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.2 1.6 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.2 1.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.2 0.6 GO:1901877 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.2 1.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.2 1.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 0.6 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.7 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 0.4 GO:0003032 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.1 0.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.3 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.1 0.5 GO:0030070 insulin processing(GO:0030070)
0.1 0.4 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 0.6 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 1.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.3 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 0.3 GO:2000547 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.1 0.9 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.3 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 0.5 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.1 0.4 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.2 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.1 0.1 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.1 0.2 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.2 GO:0019087 transformation of host cell by virus(GO:0019087)
0.1 0.3 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.1 0.4 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.1 0.7 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.3 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 1.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 2.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 0.5 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 0.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.2 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 0.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.5 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.1 0.3 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 0.3 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.1 0.2 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.2 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 0.2 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.0 0.3 GO:0021764 amygdala development(GO:0021764)
0.0 0.5 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.3 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.0 0.1 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.0 0.1 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.5 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.0 0.1 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.0 0.7 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.6 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237)
0.0 0.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.2 GO:0060701 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.2 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:1990785 response to water-immersion restraint stress(GO:1990785)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.1 GO:1901529 positive regulation of anion channel activity(GO:1901529) positive regulation of anion transmembrane transport(GO:1903961)
0.0 0.1 GO:0070352 positive regulation of white fat cell proliferation(GO:0070352)
0.0 0.1 GO:1904172 NAD transport(GO:0043132) regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.0 0.2 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.2 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.2 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0021564 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0021893 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.5 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.4 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.2 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.2 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.0 0.1 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 0.6 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.1 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.1 GO:0070572 positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.1 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.8 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.1 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.0 0.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.1 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.2 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 0.4 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.1 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 0.3 GO:0008228 opsonization(GO:0008228)
0.0 0.0 GO:1905069 allantois development(GO:1905069)
0.0 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.2 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.4 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.3 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0015811 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.0 GO:0034241 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.0 0.1 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.1 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.2 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.1 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.4 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.0 GO:0043049 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.4 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.0 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.0 GO:1900081 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.0 0.6 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.1 0.4 GO:0097444 spine apparatus(GO:0097444)
0.1 0.6 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.3 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.4 GO:0030478 actin cap(GO:0030478)
0.1 0.7 GO:0001940 male pronucleus(GO:0001940)
0.1 1.1 GO:0005915 zonula adherens(GO:0005915)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.1 0.3 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 1.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.2 GO:1990923 PET complex(GO:1990923)
0.0 1.7 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.7 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.1 GO:0035838 growing cell tip(GO:0035838)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0033643 host cell part(GO:0033643)
0.0 0.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.3 1.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 1.4 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.2 0.9 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.2 1.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.4 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 0.4 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 1.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.3 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.5 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.2 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.1 1.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.4 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.3 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.7 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.1 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.3 GO:0002046 opsin binding(GO:0002046)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.2 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 0.3 GO:0031013 troponin I binding(GO:0031013)
0.1 0.6 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 0.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.5 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.3 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 1.0 GO:0005537 mannose binding(GO:0005537)
0.0 1.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 1.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 3.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.1 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.3 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 1.1 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.2 GO:0034584 piRNA binding(GO:0034584)
0.0 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 1.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.9 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.2 GO:0042835 BRE binding(GO:0042835)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.3 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0016160 amylase activity(GO:0016160)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.1 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.5 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.3 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.0 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.0 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.0 0.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.5 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 2.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 2.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.3 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.5 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 1.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.6 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 0.6 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.2 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.9 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.2 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.0 0.2 REACTOME SHC RELATED EVENTS Genes involved in SHC-related events
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 2.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane