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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for FOXO4

Z-value: 0.90

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Transcription factors associated with FOXO4

Gene Symbol Gene ID Gene Info
FOXO4
ENSG00000184481.12 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXO4hg19_v2_chrX_+_70316005_703160470.519.6e-03Click!

Activity profile of FOXO4 motif

Sorted Z-values of FOXO4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_186696425 5.80 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr3_-_112127981 3.60 ENST00000486726.2
RP11-231E6.1
RP11-231E6.1
chr4_-_186697044 3.47 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr9_+_27109392 3.30 ENST00000406359.4
TEK
TEK tyrosine kinase, endothelial
chr2_+_12857015 3.00 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr2_+_12857043 3.00 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr4_-_70626314 2.88 ENST00000510821.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr13_+_32838801 2.87 ENST00000542859.1
FRY
furry homolog (Drosophila)
chr4_-_159080806 2.72 ENST00000590648.1
FAM198B
family with sequence similarity 198, member B
chr3_-_18466026 2.61 ENST00000417717.2
SATB1
SATB homeobox 1
chr18_+_72922710 2.23 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr18_+_77160282 2.01 ENST00000318065.5
ENST00000545796.1
ENST00000592223.1
ENST00000329101.4
ENST00000586434.1
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr17_-_67138015 2.01 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr9_-_39288092 1.99 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3
contactin associated protein-like 3
chr4_-_70626430 1.86 ENST00000310613.3
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr15_-_52970820 1.84 ENST00000261844.7
ENST00000399202.4
ENST00000562135.1
FAM214A
family with sequence similarity 214, member A
chr2_-_165424973 1.78 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr4_-_102268628 1.62 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr12_+_96588279 1.61 ENST00000552142.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr7_+_12250886 1.53 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr18_-_53303123 1.44 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr7_+_134832808 1.40 ENST00000275767.3
TMEM140
transmembrane protein 140
chr6_+_123110465 1.39 ENST00000539041.1
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr1_+_87797351 1.38 ENST00000370542.1
LMO4
LIM domain only 4
chr3_+_132316081 1.35 ENST00000249887.2
ACKR4
atypical chemokine receptor 4
chr2_+_109204743 1.35 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr4_-_90757364 1.31 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_90756769 1.31 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr9_-_86432547 1.23 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr18_+_6834472 1.19 ENST00000581099.1
ENST00000419673.2
ENST00000531294.1
ARHGAP28
Rho GTPase activating protein 28
chr11_-_89223883 1.13 ENST00000528341.1
NOX4
NADPH oxidase 4
chr7_-_27702455 1.13 ENST00000265395.2
HIBADH
3-hydroxyisobutyrate dehydrogenase
chr10_-_25241499 1.13 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
PRTFDC1
phosphoribosyl transferase domain containing 1
chr2_+_65283506 1.10 ENST00000377990.2
CEP68
centrosomal protein 68kDa
chr8_+_74903580 1.09 ENST00000284818.2
ENST00000518893.1
LY96
lymphocyte antigen 96
chr11_-_89224139 1.06 ENST00000413594.2
NOX4
NADPH oxidase 4
chr2_+_109204909 1.06 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr15_-_31283798 1.05 ENST00000435680.1
ENST00000425768.1
MTMR10
myotubularin related protein 10
chr3_-_28390581 1.05 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr3_+_124223586 1.05 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr9_+_27109133 1.04 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr16_-_15736881 1.04 ENST00000540441.2
KIAA0430
KIAA0430
chr3_-_141868293 1.03 ENST00000317104.7
ENST00000494358.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_-_67057047 1.02 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr9_-_13175823 1.02 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr3_-_101232019 0.99 ENST00000394095.2
ENST00000394091.1
ENST00000394094.2
ENST00000358203.3
ENST00000348610.3
ENST00000314261.7
SENP7
SUMO1/sentrin specific peptidase 7
chr8_-_6420565 0.99 ENST00000338312.6
ANGPT2
angiopoietin 2
chr17_-_67057114 0.98 ENST00000370732.2
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr1_+_63989004 0.98 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr11_-_89224299 0.98 ENST00000343727.5
ENST00000531342.1
ENST00000375979.3
NOX4
NADPH oxidase 4
chr4_-_152149033 0.97 ENST00000514152.1
SH3D19
SH3 domain containing 19
chr1_+_145524891 0.95 ENST00000369304.3
ITGA10
integrin, alpha 10
chr9_+_108006880 0.94 ENST00000374723.1
ENST00000374720.3
ENST00000374724.1
SLC44A1
solute carrier family 44 (choline transporter), member 1
chr2_+_65283529 0.93 ENST00000546106.1
ENST00000537589.1
ENST00000260569.4
CEP68
centrosomal protein 68kDa
chr6_-_42016385 0.93 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
CCND3
cyclin D3
chr19_+_18111927 0.92 ENST00000379656.3
ARRDC2
arrestin domain containing 2
chrX_-_20236970 0.90 ENST00000379548.4
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr12_+_96588143 0.87 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr1_+_97188188 0.87 ENST00000541987.1
PTBP2
polypyrimidine tract binding protein 2
chr3_-_28390298 0.87 ENST00000457172.1
AZI2
5-azacytidine induced 2
chr14_+_102276132 0.86 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr8_-_6420759 0.86 ENST00000523120.1
ANGPT2
angiopoietin 2
chr2_-_101767715 0.85 ENST00000376840.4
ENST00000409318.1
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr12_-_71031185 0.84 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr14_-_103987679 0.84 ENST00000553610.1
CKB
creatine kinase, brain
chr3_+_122513642 0.84 ENST00000261038.5
DIRC2
disrupted in renal carcinoma 2
chr13_+_103459704 0.80 ENST00000602836.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr12_-_68696652 0.79 ENST00000539972.1
MDM1
Mdm1 nuclear protein homolog (mouse)
chr10_-_49482907 0.79 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr12_-_12491608 0.79 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr3_-_28390415 0.78 ENST00000414162.1
ENST00000420543.2
AZI2
5-azacytidine induced 2
chr1_-_16763685 0.76 ENST00000540400.1
SPATA21
spermatogenesis associated 21
chr13_-_41240717 0.76 ENST00000379561.5
FOXO1
forkhead box O1
chr2_+_66662510 0.75 ENST00000272369.9
ENST00000407092.2
MEIS1
Meis homeobox 1
chr18_+_47088401 0.75 ENST00000261292.4
ENST00000427224.2
ENST00000580036.1
LIPG
lipase, endothelial
chr14_+_102276209 0.74 ENST00000445439.3
ENST00000334743.5
ENST00000557095.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr1_+_6845497 0.73 ENST00000473578.1
ENST00000557126.1
CAMTA1
calmodulin binding transcription activator 1
chr7_+_7811992 0.72 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr12_-_71031220 0.72 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr8_-_6420777 0.71 ENST00000415216.1
ANGPT2
angiopoietin 2
chr11_+_844067 0.71 ENST00000397406.1
ENST00000409543.2
ENST00000525201.1
TSPAN4
tetraspanin 4
chr5_-_42812143 0.71 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr13_-_99630233 0.70 ENST00000376460.1
ENST00000442173.1
DOCK9
dedicator of cytokinesis 9
chr3_-_141868357 0.70 ENST00000489671.1
ENST00000475734.1
ENST00000467072.1
ENST00000499676.2
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_-_42811986 0.70 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr8_-_6420930 0.69 ENST00000325203.5
ANGPT2
angiopoietin 2
chr1_-_234667504 0.69 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr5_-_10308125 0.66 ENST00000296658.3
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr2_+_191513959 0.66 ENST00000337386.5
ENST00000357215.5
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr18_-_53069419 0.65 ENST00000570177.2
TCF4
transcription factor 4
chr11_-_94227029 0.62 ENST00000323977.3
ENST00000536754.1
ENST00000323929.3
MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
chr7_+_77469439 0.62 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr4_+_40198527 0.61 ENST00000381799.5
RHOH
ras homolog family member H
chr11_+_844406 0.60 ENST00000397404.1
TSPAN4
tetraspanin 4
chr15_-_55657428 0.60 ENST00000568543.1
CCPG1
cell cycle progression 1
chr3_-_28390120 0.59 ENST00000334100.6
AZI2
5-azacytidine induced 2
chrX_-_101112549 0.59 ENST00000537026.1
ENST00000361708.2
NXF5
nuclear RNA export factor 5
chr7_-_95064264 0.58 ENST00000536183.1
ENST00000433091.2
ENST00000222572.3
PON2
paraoxonase 2
chr14_+_50234827 0.58 ENST00000554589.1
ENST00000557247.1
KLHDC2
kelch domain containing 2
chr16_+_28858004 0.58 ENST00000322610.8
SH2B1
SH2B adaptor protein 1
chr12_-_102591604 0.58 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr18_-_30716038 0.57 ENST00000581852.1
CCDC178
coiled-coil domain containing 178
chr6_-_167571817 0.55 ENST00000366834.1
GPR31
G protein-coupled receptor 31
chr19_+_30863271 0.55 ENST00000355537.3
ZNF536
zinc finger protein 536
chr12_-_772901 0.53 ENST00000305108.4
NINJ2
ninjurin 2
chr6_-_13621126 0.52 ENST00000600057.1
AL441883.1
Uncharacterized protein
chr8_+_93895865 0.52 ENST00000391681.1
AC117834.1
AC117834.1
chr18_-_21852143 0.52 ENST00000399443.3
OSBPL1A
oxysterol binding protein-like 1A
chr9_-_88896977 0.51 ENST00000311534.6
ISCA1
iron-sulfur cluster assembly 1
chr6_-_31830655 0.51 ENST00000375631.4
NEU1
sialidase 1 (lysosomal sialidase)
chr17_+_67410832 0.51 ENST00000590474.1
MAP2K6
mitogen-activated protein kinase kinase 6
chrX_-_148676974 0.50 ENST00000524178.1
HSFX2
heat shock transcription factor family, X linked 2
chr6_+_32121789 0.49 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr2_+_170683979 0.49 ENST00000418381.1
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr10_+_111985713 0.48 ENST00000239007.7
MXI1
MAX interactor 1, dimerization protein
chrX_+_148855726 0.48 ENST00000370416.4
HSFX1
heat shock transcription factor family, X linked 1
chr6_+_32121908 0.47 ENST00000375143.2
ENST00000424499.1
PPT2
palmitoyl-protein thioesterase 2
chr1_-_24469602 0.47 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr15_+_49462434 0.46 ENST00000558145.1
ENST00000543495.1
ENST00000544523.1
ENST00000560138.1
GALK2
galactokinase 2
chr1_+_153940713 0.46 ENST00000368601.1
ENST00000368603.1
ENST00000368600.3
CREB3L4
cAMP responsive element binding protein 3-like 4
chr1_-_54405773 0.46 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr6_-_105627735 0.46 ENST00000254765.3
POPDC3
popeye domain containing 3
chr1_-_227505289 0.46 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr14_+_23067146 0.46 ENST00000428304.2
ABHD4
abhydrolase domain containing 4
chr7_+_101460882 0.46 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr14_+_22985251 0.44 ENST00000390510.1
TRAJ27
T cell receptor alpha joining 27
chr1_+_153940346 0.44 ENST00000405694.3
ENST00000449724.1
ENST00000368607.3
ENST00000271889.4
CREB3L4
cAMP responsive element binding protein 3-like 4
chr3_+_159570722 0.44 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr7_-_6098770 0.43 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
EIF2AK1
eukaryotic translation initiation factor 2-alpha kinase 1
chr2_+_170683942 0.43 ENST00000272793.5
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr11_-_82745238 0.43 ENST00000531021.1
RAB30
RAB30, member RAS oncogene family
chr19_-_40732594 0.42 ENST00000430325.2
ENST00000433940.1
CNTD2
cyclin N-terminal domain containing 2
chr7_-_105332084 0.42 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr1_+_95616933 0.41 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr6_-_46889694 0.41 ENST00000283296.7
ENST00000362015.4
ENST00000456426.2
GPR116
G protein-coupled receptor 116
chr12_+_118454500 0.40 ENST00000537315.1
ENST00000229043.3
ENST00000484086.2
ENST00000420967.1
ENST00000454402.2
ENST00000392542.2
ENST00000535092.1
RFC5
replication factor C (activator 1) 5, 36.5kDa
chr2_+_175260451 0.40 ENST00000458563.1
ENST00000409673.3
ENST00000272732.6
ENST00000435964.1
SCRN3
secernin 3
chr11_-_62476965 0.39 ENST00000405837.1
ENST00000531524.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_62477041 0.39 ENST00000433053.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr3_+_107096188 0.39 ENST00000261058.1
CCDC54
coiled-coil domain containing 54
chr3_-_157221128 0.39 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1
chr4_-_140223670 0.38 ENST00000394228.1
ENST00000539387.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr5_-_107703556 0.38 ENST00000496714.1
FBXL17
F-box and leucine-rich repeat protein 17
chr11_-_114466477 0.38 ENST00000375478.3
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr7_-_38394118 0.38 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr9_+_70856397 0.37 ENST00000360171.6
CBWD3
COBW domain containing 3
chr1_+_117297007 0.36 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chr5_+_79703823 0.36 ENST00000338008.5
ENST00000510158.1
ENST00000505560.1
ZFYVE16
zinc finger, FYVE domain containing 16
chr19_-_37019136 0.36 ENST00000592282.1
ZNF260
zinc finger protein 260
chr5_-_122758994 0.36 ENST00000306467.5
ENST00000515110.1
CEP120
centrosomal protein 120kDa
chr12_-_109219937 0.36 ENST00000546697.1
SSH1
slingshot protein phosphatase 1
chr3_+_28390637 0.35 ENST00000420223.1
ENST00000383768.2
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr11_-_107328527 0.35 ENST00000282251.5
ENST00000433523.1
CWF19L2
CWF19-like 2, cell cycle control (S. pombe)
chr13_-_41837620 0.35 ENST00000379477.1
ENST00000452359.1
ENST00000379480.4
ENST00000430347.2
MTRF1
mitochondrial translational release factor 1
chr1_-_241803649 0.35 ENST00000366554.2
OPN3
opsin 3
chr19_+_57640011 0.34 ENST00000598197.1
USP29
ubiquitin specific peptidase 29
chr5_-_125930929 0.34 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr2_-_192711968 0.34 ENST00000304141.4
SDPR
serum deprivation response
chr8_+_70404996 0.33 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr2_+_86947296 0.33 ENST00000283632.4
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr12_+_100041527 0.33 ENST00000324341.1
FAM71C
family with sequence similarity 71, member C
chr20_+_45338126 0.33 ENST00000359271.2
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr1_-_182360918 0.33 ENST00000339526.4
GLUL
glutamate-ammonia ligase
chr1_+_214163033 0.33 ENST00000607425.1
PROX1
prospero homeobox 1
chr9_+_42671887 0.32 ENST00000456520.1
ENST00000377391.3
CBWD7
COBW domain containing 7
chr20_+_18125727 0.32 ENST00000489634.2
CSRP2BP
CSRP2 binding protein
chr4_-_140223614 0.32 ENST00000394223.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr5_-_122759032 0.32 ENST00000510582.3
ENST00000328236.5
ENST00000306481.6
ENST00000508442.2
ENST00000395431.2
CEP120
centrosomal protein 120kDa
chr19_-_36523709 0.31 ENST00000592017.1
ENST00000360535.4
CLIP3
CAP-GLY domain containing linker protein 3
chr6_+_97010424 0.31 ENST00000541107.1
ENST00000450218.1
ENST00000326771.2
FHL5
four and a half LIM domains 5
chr10_-_11574274 0.31 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr17_-_39150385 0.31 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr1_+_28844778 0.31 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chr1_-_241803679 0.31 ENST00000331838.5
OPN3
opsin 3
chr9_+_706842 0.31 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr8_-_62602327 0.30 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr1_+_151739131 0.30 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chr1_-_47655686 0.30 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr11_+_128634589 0.30 ENST00000281428.8
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chrX_-_19689106 0.29 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr14_+_70918874 0.29 ENST00000603540.1
ADAM21
ADAM metallopeptidase domain 21
chr3_+_101292939 0.29 ENST00000265260.3
ENST00000469941.1
ENST00000296024.5
PCNP
PEST proteolytic signal containing nuclear protein
chr11_+_12115543 0.29 ENST00000537344.1
ENST00000532179.1
ENST00000526065.1
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr4_+_118955500 0.29 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr8_-_133772794 0.28 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71
transmembrane protein 71
chr14_-_92572894 0.28 ENST00000532032.1
ENST00000506466.1
ENST00000555381.1
ENST00000557311.1
ENST00000554592.1
ENST00000554672.1
ENST00000553491.1
ENST00000556220.1
ENST00000502250.1
ENST00000503767.1
ENST00000393287.5
ENST00000340660.6
ENST00000545170.1
ENST00000429774.2
ATXN3
ataxin 3
chr1_-_168106536 0.28 ENST00000537209.1
ENST00000361697.2
ENST00000546300.1
ENST00000367835.1
GPR161
G protein-coupled receptor 161
chr11_-_118095718 0.28 ENST00000526620.1
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_-_182360498 0.28 ENST00000417584.2
GLUL
glutamate-ammonia ligase
chr12_-_102872317 0.28 ENST00000424202.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_+_3379284 0.28 ENST00000263080.2
ASPA
aspartoacylase
chr8_-_54755789 0.28 ENST00000359530.2
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr1_-_16400086 0.28 ENST00000375662.4
FAM131C
family with sequence similarity 131, member C
chr19_-_7293942 0.27 ENST00000341500.5
ENST00000302850.5
INSR
insulin receptor
chr3_+_48956249 0.27 ENST00000452882.1
ENST00000430423.1
ENST00000356401.4
ENST00000449376.1
ENST00000420814.1
ENST00000449729.1
ENST00000433170.1
ARIH2
ariadne RBR E3 ubiquitin protein ligase 2
chr12_-_24103954 0.27 ENST00000441133.2
ENST00000545921.1
SOX5
SRY (sex determining region Y)-box 5
chr16_+_14980632 0.27 ENST00000565655.1
NOMO1
NODAL modulator 1
chr19_+_17378278 0.27 ENST00000596335.1
ENST00000601436.1
ENST00000595632.1
BABAM1
BRISC and BRCA1 A complex member 1
chr8_+_21777159 0.26 ENST00000434536.1
ENST00000252512.9
XPO7
exportin 7
chr4_-_14889791 0.26 ENST00000509654.1
ENST00000515031.1
ENST00000505089.2
LINC00504
long intergenic non-protein coding RNA 504

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.1 7.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.7 3.3 GO:0044565 dendritic cell proliferation(GO:0044565)
0.5 1.6 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.5 2.6 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.4 2.2 GO:0060023 soft palate development(GO:0060023)
0.4 1.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 1.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.4 2.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 9.5 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 0.5 GO:0072709 cellular response to sorbitol(GO:0072709)
0.2 0.8 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 1.1 GO:0006574 valine catabolic process(GO:0006574)
0.2 0.7 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.2 0.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 4.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 1.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.2 0.6 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.2 0.8 GO:1902617 response to fluoride(GO:1902617)
0.1 1.0 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.1 1.3 GO:0042426 choline catabolic process(GO:0042426)
0.1 2.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.6 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.4 GO:0098976 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.1 2.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.3 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.4 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.1 1.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.3 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 1.0 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 0.3 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.3 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 1.4 GO:0042659 spinal cord association neuron differentiation(GO:0021527) regulation of cell fate specification(GO:0042659)
0.1 3.2 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.3 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.3 GO:1990535 transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535)
0.1 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.1 0.2 GO:0002840 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.1 0.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.2 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.1 2.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.4 GO:1902715 regulation of myeloid dendritic cell activation(GO:0030885) positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.1 GO:0035565 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.0 1.1 GO:0035855 megakaryocyte development(GO:0035855)
0.0 1.8 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 1.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.2 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.0 0.2 GO:0009597 detection of virus(GO:0009597)
0.0 0.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.0 0.8 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.0 0.1 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.9 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.2 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.2 GO:0046606 negative regulation of centrosome cycle(GO:0046606)
0.0 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.2 GO:0044211 CTP salvage(GO:0044211)
0.0 0.5 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.6 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.8 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.3 GO:0006449 regulation of translational termination(GO:0006449)
0.0 1.3 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.9 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.0 0.2 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 1.6 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.5 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.0 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.5 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.5 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.7 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 1.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.2 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.3 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.0 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.5 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.2 1.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 1.6 GO:0005955 calcineurin complex(GO:0005955)
0.2 3.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 2.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 3.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.5 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.1 2.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 1.0 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.3 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 1.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 8.5 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.6 GO:0097386 glial cell projection(GO:0097386)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 1.7 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 2.8 GO:0000922 spindle pole(GO:0000922)
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 2.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.7 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.5 2.6 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.3 9.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 1.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.3 5.4 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 3.2 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 2.0 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.2 0.6 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.2 4.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 1.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 2.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.0 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 0.5 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.2 0.6 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 1.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 1.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.3 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 1.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.7 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.5 GO:0097001 ceramide binding(GO:0097001)
0.1 0.5 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.2 GO:0004917 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.1 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0043199 sulfate binding(GO:0043199)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 1.6 GO:0019956 chemokine binding(GO:0019956)
0.0 0.4 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.3 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.3 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 0.3 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.8 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 1.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 1.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.6 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.1 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 4.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.8 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 2.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.7 PID E2F PATHWAY E2F transcription factor network
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 4.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 4.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.7 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.7 REACTOME OPSINS Genes involved in Opsins
0.0 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.8 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK