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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for FUBP1
Z-value: 1.09
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Transcription factors associated with FUBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FUBP1 | hg19_v2_chr1_-_78444776_78444800 | -0.14 | 5.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_33891362 Show fit | 6.02 |
ENST00000395833.3
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr4_-_16900242 Show fit | 5.14 |
ENST00000502640.1
ENST00000506732.1 |
LIM domain binding 2 |
|
| chr4_-_16900184 Show fit | 4.36 |
ENST00000515064.1
|
LIM domain binding 2 |
|
| chr4_-_101439242 Show fit | 4.35 |
ENST00000296420.4
|
endomucin |
|
| chr4_-_16900217 Show fit | 4.27 |
ENST00000441778.2
|
LIM domain binding 2 |
|
| chr4_-_16900410 Show fit | 4.23 |
ENST00000304523.5
|
LIM domain binding 2 |
|
| chr1_+_84609944 Show fit | 4.19 |
ENST00000370685.3
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr4_-_101439148 Show fit | 3.49 |
ENST00000511970.1
ENST00000502569.1 ENST00000305864.3 |
endomucin |
|
| chr3_-_112127981 Show fit | 3.02 |
ENST00000486726.2
|
RP11-231E6.1 |
|
| chr21_+_17791648 Show fit | 2.75 |
ENST00000602892.1
ENST00000418813.2 ENST00000435697.1 |
long intergenic non-protein coding RNA 478 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FUBP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 18.3 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.2 | 6.0 | GO:0042789 | mRNA transcription from RNA polymerase II promoter(GO:0042789) |
| 0.6 | 4.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.9 | 3.6 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.3 | 3.1 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.0 | 2.5 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.2 | 2.3 | GO:0034350 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.2 | 2.3 | GO:0042908 | xenobiotic transport(GO:0042908) |
| 0.1 | 2.2 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.7 | 2.0 | GO:0014839 | myoblast migration involved in skeletal muscle regeneration(GO:0014839) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 4.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 3.1 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 2.0 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 1.8 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 1.7 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.0 | 1.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 1.6 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.1 | 1.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 1.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 18.0 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 6.0 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.2 | 4.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 3.6 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 3.2 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.6 | 3.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.5 | 2.3 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.3 | 2.3 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.3 | 2.2 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.3 | 2.0 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 4.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 4.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.3 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 1.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 1.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 3.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 2.3 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 2.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 2.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 1.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 1.4 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 1.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.3 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |