Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for GATA2
Z-value: 0.87
Motif logo
Transcription factors associated with GATA2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA2 | hg19_v2_chr3_-_128206759_128206781 | -0.17 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.0 | 3.4 | GO:0007286 | spermatid development(GO:0007286) |
| 0.1 | 2.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 2.0 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.4 | 1.8 | GO:0051945 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 1.8 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 1.8 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.6 | 1.7 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 1.6 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.1 | 1.6 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.2 | 3.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 3.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 2.0 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 1.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 1.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 1.7 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 1.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 3.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 3.5 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 2.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 2.3 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.4 | 1.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.3 | 1.7 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 1.6 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 1.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 1.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 3.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.4 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.3 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 2.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.2 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 1.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 1.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.6 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 1.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |