ISMARA results: GATA3

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GATA3

Z-value: 2.08

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Transcription factors associated with GATA3

Gene Symbol	Gene ID	Gene Info
GATA3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000107485.11	GATA binding protein 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA3	hg19_v2_chr10_+_8096769_8096787	-0.81	1.1e-06	Click!

Activity profile of GATA3 motif

Sorted Z-values of GATA3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_29527702 Show fit	13.55	ENST00000377050.4	UBD Ensembl NCBI GeneCards UniProt NextProt Show fit	ubiquitin D
chr10_-_49860525 Show fit	7.51	ENST00000435790.2	ARHGAP22 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 22
chr3_-_127541194 Show fit	7.10	ENST00000453507.2	MGLL Ensembl NCBI GeneCards UniProt NextProt Show fit	monoglyceride lipase
chr2_+_228678550 Show fit	7.04	ENST00000409189.3 ENST00000358813.4	CCL20 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 20
chr19_+_4229495 Show fit	6.71	ENST00000221847.5	EBI3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Epstein-Barr virus induced 3
chr3_-_79068594 Show fit	5.80	ENST00000436010.2	ROBO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr15_+_67430339 Show fit	5.57	ENST00000439724.3	SMAD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SMAD family member 3
chr9_-_123691047 Show fit	5.53	ENST00000373887.3	TRAF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TNF receptor-associated factor 1
chr2_-_89513402 Show fit	5.48	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-27
chr9_-_123676827 Show fit	5.32	ENST00000546084.1	TRAF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TNF receptor-associated factor 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2	15.2	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
2.7	13.5	GO:0070842	aggresome assembly(GO:0070842)
2.4	12.0	GO:0061767	negative regulation of lung blood pressure(GO:0061767)
0.1	11.8	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.2	9.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2	7.9	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.8	7.7	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1	7.4	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.9	7.3	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)

Showing 1 to 10 of 933 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	22.1	GO:0005615	extracellular space(GO:0005615)
0.1	21.5	GO:0001650	fibrillar center(GO:0001650)
0.2	13.4	GO:0045095	keratin filament(GO:0045095)
1.5	12.0	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.1	11.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	10.0	GO:0043296	apical junction complex(GO:0043296)
1.0	8.7	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	8.7	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.9	7.4	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
0.4	7.4	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)

Showing 1 to 10 of 329 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.3	GO:0004984	olfactory receptor activity(GO:0004984)
1.0	16.4	GO:0031996	thioesterase binding(GO:0031996)
0.7	13.7	GO:0070628	proteasome binding(GO:0070628)
2.4	12.0	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
0.0	11.7	GO:0030695	GTPase regulator activity(GO:0030695)
0.9	9.7	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3	9.2	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3	9.2	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3	8.8	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	8.1	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Showing 1 to 10 of 580 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	30.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1	22.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	12.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	11.8	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	9.5	PID AURORA B PATHWAY	Aurora B signaling
0.3	9.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3	9.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	8.7	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.2	8.7	PID IL1 PATHWAY	IL1-mediated signaling events
0.2	8.6	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 10 of 93 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	16.3	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	14.5	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.4	13.4	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.2	13.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	11.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	10.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.3	9.0	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	8.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	8.5	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels

Showing 1 to 10 of 155 entries

Results for GATA3

Z-value: 2.08

Motif logo

Transcription factors associated with GATA3

Activity-expression correlation:

Activity profile of GATA3 motif

Sorted Z-values of GATA3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: