ISMARA results: GATA6

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GATA6

Z-value: 0.32

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Transcription factors associated with GATA6

Gene Symbol	Gene ID	Gene Info
GATA6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000141448.4	GATA binding protein 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA6	hg19_v2_chr18_+_19749386_19749404	-0.17	4.2e-01	Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_44065889 Show fit	0.45	ENST00000543989.1 ENST00000405322.1	ABCG5 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_44065946 Show fit	0.43	ENST00000260645.1	ABCG5 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_69098566 Show fit	0.26	ENST00000295379.1	BMP10 Ensembl NCBI GeneCards UniProt NextProt Show fit	bone morphogenetic protein 10
chr11_+_10326612 Show fit	0.25	ENST00000534464.1 ENST00000530439.1 ENST00000524948.1 ENST00000528655.1 ENST00000526492.1 ENST00000525063.1	ADM Ensembl NCBI GeneCards UniProt NextProt Show fit	adrenomedullin
chr3_+_88188254 Show fit	0.25	ENST00000309495.5	ZNF654 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 654
chr5_-_135290705 Show fit	0.21	ENST00000274507.1	LECT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	leukocyte cell-derived chemotaxin 2
chr1_-_158656488 Show fit	0.21	ENST00000368147.4	SPTA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr2_-_219850277 Show fit	0.21	ENST00000295727.1	FEV Ensembl NCBI GeneCards UniProt NextProt Show fit	FEV (ETS oncogene family)
chr7_-_107880508 Show fit	0.19	ENST00000425651.2	NRCAM Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal cell adhesion molecule
chr12_-_10151773 Show fit	0.18	ENST00000298527.6 ENST00000348658.4	CLEC1B Ensembl NCBI GeneCards UniProt NextProt Show fit	C-type lectin domain family 1, member B

Showing 1 to 10 of 119 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0045796	negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.0	0.3	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.3	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.2	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0	0.2	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.2	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.2	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.2	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.1	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0	0.1	GO:0031860	telomeric 3' overhang formation(GO:0031860)

Showing 1 to 10 of 17 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.2	GO:0032437	cuticular plate(GO:0032437)
0.0	0.2	GO:0070081	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.1	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.0	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)

Showing 1 to 9 of 9 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.3	GO:0031433	telethonin binding(GO:0031433)
0.1	0.2	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.1	GO:0004998	transferrin receptor activity(GO:0004998)
0.0	0.1	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0008506	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.1	GO:0030250	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 2 of 2 entries

Results for GATA6

Z-value: 0.32

Motif logo

Transcription factors associated with GATA6

Activity-expression correlation:

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: