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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GATA6

Z-value: 0.32

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_19749404-0.174.2e-01Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_44065889 0.45 ENST00000543989.1
ENST00000405322.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_44065946 0.43 ENST00000260645.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_69098566 0.26 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr11_+_10326612 0.25 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr3_+_88188254 0.25 ENST00000309495.5
ZNF654
zinc finger protein 654
chr5_-_135290705 0.21 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr1_-_158656488 0.21 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr2_-_219850277 0.21 ENST00000295727.1
FEV
FEV (ETS oncogene family)
chr7_-_107880508 0.19 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr12_-_10151773 0.18 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr19_-_13213662 0.17 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr16_+_333152 0.17 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2
chr1_+_174846570 0.15 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_4430371 0.15 ENST00000179259.4
C12orf5
chromosome 12 open reading frame 5
chr7_-_100239132 0.14 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr2_+_169757750 0.14 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr11_-_116708302 0.14 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
APOA1
apolipoprotein A-I
chr12_+_109785708 0.12 ENST00000310903.5
MYO1H
myosin IH
chr14_+_75988768 0.12 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr10_+_118350522 0.12 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr5_+_131892603 0.11 ENST00000378823.3
ENST00000265335.6
RAD50
RAD50 homolog (S. cerevisiae)
chr10_+_71075552 0.11 ENST00000298649.3
HK1
hexokinase 1
chr10_+_118350468 0.11 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr12_-_52995291 0.11 ENST00000293745.2
ENST00000354310.4
KRT72
keratin 72
chr1_-_42630389 0.11 ENST00000357001.2
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr1_-_205912577 0.10 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr16_+_616995 0.10 ENST00000293874.2
ENST00000409527.2
ENST00000424439.2
ENST00000540585.1
PIGQ
NHLRC4
phosphatidylinositol glycan anchor biosynthesis, class Q
NHL repeat containing 4
chr16_+_202686 0.10 ENST00000252951.2
HBZ
hemoglobin, zeta
chr11_-_47374246 0.10 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr1_+_25598872 0.10 ENST00000328664.4
RHD
Rh blood group, D antigen
chr6_+_50061315 0.10 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr20_+_43935474 0.09 ENST00000372743.1
ENST00000372741.3
ENST00000343694.3
RBPJL
recombination signal binding protein for immunoglobulin kappa J region-like
chr12_-_54689532 0.09 ENST00000540264.2
ENST00000312156.4
NFE2
nuclear factor, erythroid 2
chr1_+_161136180 0.09 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
PPOX
protoporphyrinogen oxidase
chr20_+_54967409 0.09 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr4_+_100495864 0.08 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr8_-_20040601 0.08 ENST00000265808.7
ENST00000522513.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr2_-_152830479 0.08 ENST00000360283.6
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr6_-_30128657 0.07 ENST00000449742.2
ENST00000376704.3
TRIM10
tripartite motif containing 10
chr10_+_24755416 0.07 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr9_+_118950325 0.07 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr19_+_10397648 0.07 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397621 0.07 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr8_-_20040638 0.07 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr8_-_93107696 0.07 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_59612969 0.07 ENST00000541311.1
ENST00000257248.2
GIF
gastric intrinsic factor (vitamin B synthesis)
chr9_+_125796806 0.06 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr1_+_25599018 0.06 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr1_-_226187013 0.06 ENST00000272091.7
SDE2
SDE2 telomere maintenance homolog (S. pombe)
chr3_-_47950745 0.06 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr20_-_54967187 0.06 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr19_+_36132631 0.06 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ETV2
ets variant 2
chr1_-_167487758 0.06 ENST00000362089.5
CD247
CD247 molecule
chr1_-_167487808 0.05 ENST00000392122.3
CD247
CD247 molecule
chr14_+_75988851 0.05 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr15_+_59279851 0.05 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr1_+_25598989 0.05 ENST00000454452.2
RHD
Rh blood group, D antigen
chr17_+_4835580 0.05 ENST00000329125.5
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr6_-_46048116 0.05 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr9_-_114937676 0.05 ENST00000374270.3
SUSD1
sushi domain containing 1
chr13_-_46716969 0.05 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_55549624 0.05 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)
chr12_+_72332618 0.05 ENST00000333850.3
TPH2
tryptophan hydroxylase 2
chr6_+_12290586 0.05 ENST00000379375.5
EDN1
endothelin 1
chr15_-_43513187 0.05 ENST00000540029.1
ENST00000441366.2
EPB42
erythrocyte membrane protein band 4.2
chr10_+_118305435 0.04 ENST00000369221.2
PNLIP
pancreatic lipase
chr9_-_114937543 0.04 ENST00000374264.2
ENST00000374263.3
SUSD1
sushi domain containing 1
chr2_+_44066101 0.04 ENST00000272286.2
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr5_+_159848807 0.04 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr13_+_24144509 0.04 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr2_+_102927962 0.04 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
IL1RL1
IL18R1
interleukin 1 receptor-like 1
interleukin 18 receptor 1
chr8_-_95449155 0.04 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr10_-_129691195 0.04 ENST00000368671.3
CLRN3
clarin 3
chr3_+_137717571 0.04 ENST00000343735.4
CLDN18
claudin 18
chr4_-_103266219 0.04 ENST00000394833.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr14_+_53173890 0.04 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr3_+_137490748 0.04 ENST00000478772.1
RP11-2A4.3
RP11-2A4.3
chr9_-_114937465 0.04 ENST00000355396.3
SUSD1
sushi domain containing 1
chr14_+_53173910 0.03 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr12_+_122880045 0.03 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
RP11-450K4.1
chr19_-_51522955 0.03 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chrX_+_37865804 0.03 ENST00000297875.2
ENST00000357972.5
SYTL5
synaptotagmin-like 5
chr16_+_71560154 0.03 ENST00000539698.3
CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr3_+_69812877 0.03 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr16_+_4475806 0.03 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
DNAJA3
DnaJ (Hsp40) homolog, subfamily A, member 3
chr1_+_12524965 0.03 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr16_+_71560023 0.03 ENST00000572450.1
CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr5_-_33984786 0.03 ENST00000296589.4
SLC45A2
solute carrier family 45, member 2
chr5_-_33984741 0.03 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr15_+_49715293 0.02 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr4_+_15376165 0.02 ENST00000382383.3
ENST00000429690.1
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr6_+_130339710 0.02 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr17_+_74381343 0.02 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr11_+_118958689 0.02 ENST00000535253.1
ENST00000392841.1
HMBS
hydroxymethylbilane synthase
chr8_-_93107443 0.02 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_33795533 0.02 ENST00000379405.3
PRSS3
protease, serine, 3
chr2_+_220436917 0.02 ENST00000243786.2
INHA
inhibin, alpha
chr12_+_53818855 0.02 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor, type II
chr13_+_24144796 0.02 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr2_+_87565634 0.02 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr12_+_70219052 0.02 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr12_+_111843749 0.02 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr2_-_90538397 0.01 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr22_+_35462129 0.01 ENST00000404699.2
ENST00000308700.6
ISX
intestine-specific homeobox
chr1_+_50574585 0.01 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr17_+_4675175 0.01 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr7_+_142457315 0.01 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr12_-_120765565 0.01 ENST00000423423.3
ENST00000308366.4
PLA2G1B
phospholipase A2, group IB (pancreas)
chr18_-_45663666 0.01 ENST00000535628.2
ZBTB7C
zinc finger and BTB domain containing 7C
chr22_-_20231207 0.01 ENST00000425986.1
RTN4R
reticulon 4 receptor
chr4_-_103266355 0.01 ENST00000424970.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr18_-_28742813 0.01 ENST00000257197.3
ENST00000257198.5
DSC1
desmocollin 1
chr8_+_21823726 0.00 ENST00000433566.4
XPO7
exportin 7
chr11_-_66206260 0.00 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
MRPL11
mitochondrial ribosomal protein L11
chr5_+_1201703 0.00 ENST00000304460.10
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chrX_+_107288239 0.00 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr16_+_67022476 0.00 ENST00000540947.2
CES4A
carboxylesterase 4A
chr16_+_67022582 0.00 ENST00000541479.1
ENST00000338718.4
CES4A
carboxylesterase 4A
chr20_+_31669333 0.00 ENST00000375483.3
BPIFB4
BPI fold containing family B, member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0045796 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.0 0.3 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.3 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.0 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.1 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.0 0.1 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.2 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.2 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 1.0 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0008506 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins