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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GATA6

Z-value: 0.32

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_19749404-0.174.2e-01Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_44065889 0.45 ENST00000543989.1
ENST00000405322.1
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_44065946 0.43 ENST00000260645.1
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_69098566 0.26 ENST00000295379.1
bone morphogenetic protein 10
chr11_+_10326612 0.25 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
adrenomedullin
chr3_+_88188254 0.25 ENST00000309495.5
zinc finger protein 654
chr5_-_135290705 0.21 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr1_-_158656488 0.21 ENST00000368147.4
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr2_-_219850277 0.21 ENST00000295727.1
FEV (ETS oncogene family)
chr7_-_107880508 0.19 ENST00000425651.2
neuronal cell adhesion molecule
chr12_-_10151773 0.18 ENST00000298527.6
ENST00000348658.4
C-type lectin domain family 1, member B
chr19_-_13213662 0.17 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr16_+_333152 0.17 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
protein disulfide isomerase family A, member 2
chr1_+_174846570 0.15 ENST00000392064.2
RAB GTPase activating protein 1-like
chr12_+_4430371 0.15 ENST00000179259.4
chromosome 12 open reading frame 5
chr7_-_100239132 0.14 ENST00000223051.3
ENST00000431692.1
transferrin receptor 2
chr2_+_169757750 0.14 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
glucose-6-phosphatase, catalytic, 2
chr11_-_116708302 0.14 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
apolipoprotein A-I
chr12_+_109785708 0.12 ENST00000310903.5
myosin IH
chr14_+_75988768 0.12 ENST00000286639.6
basic leucine zipper transcription factor, ATF-like
chr10_+_118350522 0.12 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
pancreatic lipase-related protein 1
chr5_+_131892603 0.11 ENST00000378823.3
ENST00000265335.6
RAD50 homolog (S. cerevisiae)
chr10_+_71075552 0.11 ENST00000298649.3
hexokinase 1
chr10_+_118350468 0.11 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
pancreatic lipase-related protein 1
chr12_-_52995291 0.11 ENST00000293745.2
ENST00000354310.4
keratin 72
chr1_-_42630389 0.11 ENST00000357001.2
guanylate cyclase activator 2A (guanylin)
chr1_-_205912577 0.10 ENST00000367135.3
ENST00000367134.2
solute carrier family 26 (anion exchanger), member 9
chr16_+_616995 0.10 ENST00000293874.2
ENST00000409527.2
ENST00000424439.2
ENST00000540585.1
phosphatidylinositol glycan anchor biosynthesis, class Q
NHL repeat containing 4
chr16_+_202686 0.10 ENST00000252951.2
hemoglobin, zeta
chr11_-_47374246 0.10 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
myosin binding protein C, cardiac
chr1_+_25598872 0.10 ENST00000328664.4
Rh blood group, D antigen
chr6_+_50061315 0.10 ENST00000415106.1
RP11-397G17.1
chr20_+_43935474 0.09 ENST00000372743.1
ENST00000372741.3
ENST00000343694.3
recombination signal binding protein for immunoglobulin kappa J region-like
chr12_-_54689532 0.09 ENST00000540264.2
ENST00000312156.4
nuclear factor, erythroid 2
chr1_+_161136180 0.09 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
protoporphyrinogen oxidase
chr20_+_54967409 0.09 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr4_+_100495864 0.08 ENST00000265517.5
ENST00000422897.2
microsomal triglyceride transfer protein
chr8_-_20040601 0.08 ENST00000265808.7
ENST00000522513.1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr2_-_152830479 0.08 ENST00000360283.6
calcium channel, voltage-dependent, beta 4 subunit
chr6_-_30128657 0.07 ENST00000449742.2
ENST00000376704.3
tripartite motif containing 10
chr10_+_24755416 0.07 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
chr9_+_118950325 0.07 ENST00000534838.1
pregnancy-associated plasma protein A, pappalysin 1
chr19_+_10397648 0.07 ENST00000340992.4
ENST00000393717.2
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397621 0.07 ENST00000380770.3
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr8_-_20040638 0.07 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr8_-_93107696 0.07 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_59612969 0.07 ENST00000541311.1
ENST00000257248.2
gastric intrinsic factor (vitamin B synthesis)
chr9_+_125796806 0.06 ENST00000373642.1
G protein-coupled receptor 21
chr1_+_25599018 0.06 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
Rh blood group, D antigen
chr1_-_226187013 0.06 ENST00000272091.7
SDE2 telomere maintenance homolog (S. pombe)
chr3_-_47950745 0.06 ENST00000429422.1
microtubule-associated protein 4
chr20_-_54967187 0.06 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr19_+_36132631 0.06 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ets variant 2
chr1_-_167487758 0.06 ENST00000362089.5
CD247 molecule
chr1_-_167487808 0.05 ENST00000392122.3
CD247 molecule
chr14_+_75988851 0.05 ENST00000555504.1
basic leucine zipper transcription factor, ATF-like
chr15_+_59279851 0.05 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
ring finger protein 111
chr1_+_25598989 0.05 ENST00000454452.2
Rh blood group, D antigen
chr17_+_4835580 0.05 ENST00000329125.5
glycoprotein Ib (platelet), alpha polypeptide
chr6_-_46048116 0.05 ENST00000185206.6
chloride intracellular channel 5
chr9_-_114937676 0.05 ENST00000374270.3
sushi domain containing 1
chr13_-_46716969 0.05 ENST00000435666.2
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_55549624 0.05 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
glycoprotein VI (platelet)
chr12_+_72332618 0.05 ENST00000333850.3
tryptophan hydroxylase 2
chr6_+_12290586 0.05 ENST00000379375.5
endothelin 1
chr15_-_43513187 0.05 ENST00000540029.1
ENST00000441366.2
erythrocyte membrane protein band 4.2
chr10_+_118305435 0.04 ENST00000369221.2
pancreatic lipase
chr9_-_114937543 0.04 ENST00000374264.2
ENST00000374263.3
sushi domain containing 1
chr2_+_44066101 0.04 ENST00000272286.2
ATP-binding cassette, sub-family G (WHITE), member 8
chr5_+_159848807 0.04 ENST00000352433.5
pituitary tumor-transforming 1
chr13_+_24144509 0.04 ENST00000248484.4
tumor necrosis factor receptor superfamily, member 19
chr2_+_102927962 0.04 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
interleukin 1 receptor-like 1
interleukin 18 receptor 1
chr8_-_95449155 0.04 ENST00000481490.2
fibrinogen silencer binding protein
chr10_-_129691195 0.04 ENST00000368671.3
clarin 3
chr3_+_137717571 0.04 ENST00000343735.4
claudin 18
chr4_-_103266219 0.04 ENST00000394833.2
solute carrier family 39 (zinc transporter), member 8
chr14_+_53173890 0.04 ENST00000445930.2
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr3_+_137490748 0.04 ENST00000478772.1
RP11-2A4.3
chr9_-_114937465 0.04 ENST00000355396.3
sushi domain containing 1
chr14_+_53173910 0.03 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr12_+_122880045 0.03 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
chr19_-_51522955 0.03 ENST00000358789.3
kallikrein-related peptidase 10
chrX_+_37865804 0.03 ENST00000297875.2
ENST00000357972.5
synaptotagmin-like 5
chr16_+_71560154 0.03 ENST00000539698.3
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr3_+_69812877 0.03 ENST00000457080.1
ENST00000328528.6
microphthalmia-associated transcription factor
chr16_+_4475806 0.03 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
DnaJ (Hsp40) homolog, subfamily A, member 3
chr1_+_12524965 0.03 ENST00000471923.1
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr16_+_71560023 0.03 ENST00000572450.1
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr5_-_33984786 0.03 ENST00000296589.4
solute carrier family 45, member 2
chr5_-_33984741 0.03 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
solute carrier family 45, member 2
chr15_+_49715293 0.02 ENST00000267843.4
ENST00000560270.1
fibroblast growth factor 7
chr4_+_15376165 0.02 ENST00000382383.3
ENST00000429690.1
C1q and tumor necrosis factor related protein 7
chr6_+_130339710 0.02 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr17_+_74381343 0.02 ENST00000392496.3
sphingosine kinase 1
chr11_+_118958689 0.02 ENST00000535253.1
ENST00000392841.1
hydroxymethylbilane synthase
chr8_-_93107443 0.02 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_33795533 0.02 ENST00000379405.3
protease, serine, 3
chr2_+_220436917 0.02 ENST00000243786.2
inhibin, alpha
chr12_+_53818855 0.02 ENST00000550839.1
anti-Mullerian hormone receptor, type II
chr13_+_24144796 0.02 ENST00000403372.2
tumor necrosis factor receptor superfamily, member 19
chr2_+_87565634 0.02 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr12_+_70219052 0.02 ENST00000552032.2
ENST00000547771.2
myelin regulatory factor-like
chr12_+_111843749 0.02 ENST00000341259.2
SH2B adaptor protein 3
chr2_-_90538397 0.01 ENST00000443397.3
Uncharacterized protein
chr22_+_35462129 0.01 ENST00000404699.2
ENST00000308700.6
intestine-specific homeobox
chr1_+_50574585 0.01 ENST00000371824.1
ENST00000371823.4
ELAV like neuron-specific RNA binding protein 4
chr17_+_4675175 0.01 ENST00000270560.3
transmembrane 4 L six family member 5
chr7_+_142457315 0.01 ENST00000486171.1
ENST00000311737.7
protease, serine, 1 (trypsin 1)
chr12_-_120765565 0.01 ENST00000423423.3
ENST00000308366.4
phospholipase A2, group IB (pancreas)
chr18_-_45663666 0.01 ENST00000535628.2
zinc finger and BTB domain containing 7C
chr22_-_20231207 0.01 ENST00000425986.1
reticulon 4 receptor
chr4_-_103266355 0.01 ENST00000424970.2
solute carrier family 39 (zinc transporter), member 8
chr18_-_28742813 0.01 ENST00000257197.3
ENST00000257198.5
desmocollin 1
chr8_+_21823726 0.00 ENST00000433566.4
exportin 7
chr11_-_66206260 0.00 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
mitochondrial ribosomal protein L11
chr5_+_1201703 0.00 ENST00000304460.10
solute carrier family 6 (neutral amino acid transporter), member 19
chrX_+_107288239 0.00 ENST00000217957.5
V-set and immunoglobulin domain containing 1
chr16_+_67022476 0.00 ENST00000540947.2
carboxylesterase 4A
chr16_+_67022582 0.00 ENST00000541479.1
ENST00000338718.4
carboxylesterase 4A
chr20_+_31669333 0.00 ENST00000375483.3
BPI fold containing family B, member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0045796 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.0 0.3 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.3 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.0 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.1 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.0 0.1 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.2 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.2 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 1.0 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0008506 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins