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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GCM1

Z-value: 0.81

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Transcription factors associated with GCM1

Gene Symbol Gene ID Gene Info
ENSG00000137270.10 glial cells missing transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCM1hg19_v2_chr6_-_53013620_530136440.252.2e-01Click!

Activity profile of GCM1 motif

Sorted Z-values of GCM1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_10206545 4.16 ENST00000256458.4
interleukin-1 receptor-associated kinase 2
chr21_-_45660723 2.05 ENST00000344330.4
ENST00000407780.3
ENST00000400379.3
inducible T-cell co-stimulator ligand
chr11_+_13690249 1.73 ENST00000532701.1
fatty acyl CoA reductase 1
chr16_+_67063262 1.70 ENST00000565389.1
core-binding factor, beta subunit
chr8_+_104383728 1.47 ENST00000330295.5
collagen triple helix repeat containing 1
chr16_+_3115378 1.43 ENST00000529550.1
ENST00000551122.1
ENST00000525643.2
ENST00000548807.1
ENST00000528163.2
interleukin 32
chr16_+_3115611 1.41 ENST00000530890.1
ENST00000444393.3
ENST00000533097.2
ENST00000008180.9
ENST00000396890.2
ENST00000525228.1
ENST00000548652.1
ENST00000525377.2
ENST00000530538.2
ENST00000549213.1
ENST00000552936.1
ENST00000548476.1
ENST00000552664.1
ENST00000552356.1
ENST00000551513.1
ENST00000382213.3
ENST00000548246.1
interleukin 32
chr16_+_67062996 1.38 ENST00000561924.2
core-binding factor, beta subunit
chr1_-_85930246 1.27 ENST00000426972.3
dimethylarginine dimethylaminohydrolase 1
chr20_-_45061695 1.15 ENST00000445496.2
engulfment and cell motility 2
chr2_+_111878483 1.12 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2-like 11 (apoptosis facilitator)
chr13_-_30169807 1.01 ENST00000380752.5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr1_+_25071848 0.99 ENST00000374379.4
chloride intracellular channel 4
chr17_-_7493390 0.98 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SRY (sex determining region Y)-box 15
chr3_+_46448648 0.92 ENST00000399036.3
chemokine (C-C motif) receptor-like 2
chr2_+_102953608 0.89 ENST00000311734.2
ENST00000409584.1
interleukin 1 receptor-like 1
chr16_+_56598961 0.83 ENST00000219162.3
metallothionein 4
chr22_-_50964849 0.77 ENST00000543927.1
ENST00000423348.1
SCO2 cytochrome c oxidase assembly protein
chr2_+_171571827 0.76 ENST00000375281.3
Sp5 transcription factor
chr20_-_3996036 0.75 ENST00000336095.6
ring finger protein 24
chr8_+_141521386 0.75 ENST00000220913.5
ENST00000519533.1
chromatin accessibility complex 1
chr21_+_33784957 0.73 ENST00000401402.3
ENST00000382699.3
eva-1 homolog C (C. elegans)
chr19_-_1650666 0.72 ENST00000588136.1
transcription factor 3
chr18_-_5419797 0.69 ENST00000542146.1
ENST00000427684.2
erythrocyte membrane protein band 4.1-like 3
chr1_+_46805832 0.68 ENST00000474844.1
NOP2/Sun domain family, member 4
chr2_-_24583168 0.68 ENST00000361999.3
intersectin 2
chr5_+_69321361 0.67 ENST00000515588.1
small EDRK-rich factor 1B (centromeric)
chr5_+_140753444 0.66 ENST00000517434.1
protocadherin gamma subfamily A, 6
chr22_+_46476192 0.65 ENST00000443490.1
hsa-mir-4763
chr16_+_67063036 0.65 ENST00000290858.6
ENST00000564034.1
core-binding factor, beta subunit
chr2_+_90108504 0.64 ENST00000390271.2
immunoglobulin kappa variable 6D-41 (non-functional)
chr16_-_425205 0.64 ENST00000448854.1
transmembrane protein 8A
chr6_+_158402860 0.63 ENST00000367122.2
ENST00000367121.3
ENST00000355585.4
ENST00000367113.4
synaptojanin 2
chr1_+_24069952 0.63 ENST00000609199.1
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
chr11_+_35198118 0.61 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44 molecule (Indian blood group)
chr16_+_88872176 0.60 ENST00000569140.1
chromatin licensing and DNA replication factor 1
chr4_+_15704679 0.59 ENST00000382346.3
bone marrow stromal cell antigen 1
chr20_+_44441304 0.58 ENST00000352551.5
ubiquitin-conjugating enzyme E2C
chr17_+_80517216 0.55 ENST00000531030.1
ENST00000526383.2
forkhead box K2
chr10_-_73975657 0.55 ENST00000394919.1
ENST00000526751.1
activating signal cointegrator 1 complex subunit 1
chr2_-_106810742 0.54 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UDP-glucuronate decarboxylase 1
chr20_+_2854066 0.54 ENST00000455631.1
ENST00000216877.6
ENST00000399903.2
ENST00000358719.4
ENST00000431048.1
ENST00000425918.2
ENST00000430705.1
ENST00000318266.5
protein tyrosine phosphatase, receptor type, A
chr16_+_67063142 0.54 ENST00000412916.2
core-binding factor, beta subunit
chr10_+_51371390 0.53 ENST00000478381.1
ENST00000451577.2
ENST00000374098.2
ENST00000374097.2
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr2_-_106810783 0.51 ENST00000283148.7
UDP-glucuronate decarboxylase 1
chr8_+_142138799 0.51 ENST00000518668.1
DENN/MADD domain containing 3
chr2_+_47168630 0.49 ENST00000263737.6
tetratricopeptide repeat domain 7A
chr10_-_73976025 0.49 ENST00000342444.4
ENST00000533958.1
ENST00000527593.1
ENST00000394915.3
ENST00000530461.1
ENST00000317168.6
ENST00000524829.1
activating signal cointegrator 1 complex subunit 1
chr1_+_24069642 0.49 ENST00000418390.2
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
chr19_-_1021113 0.48 ENST00000333175.5
ENST00000356663.3
transmembrane protein 259
chr12_-_122238464 0.48 ENST00000546227.1
ras homolog family member F (in filopodia)
chr1_-_148347506 0.48 ENST00000369189.3
neuroblastoma breakpoint family, member 20
chr2_-_89459813 0.47 ENST00000390256.2
immunoglobulin kappa variable 6-21 (non-functional)
chr2_+_90060377 0.47 ENST00000436451.2
immunoglobulin kappa variable 6D-21 (non-functional)
chr9_-_138591341 0.47 ENST00000298466.5
ENST00000425225.1
spermatogenesis and oogenesis specific basic helix-loop-helix 1
chr17_-_7218403 0.46 ENST00000570780.1
G protein pathway suppressor 2
chr2_-_230096756 0.46 ENST00000354069.6
phosphotyrosine interaction domain containing 1
chr5_-_142780280 0.46 ENST00000424646.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_11658655 0.45 ENST00000588935.1
calponin 1, basic, smooth muscle
chr11_-_100999775 0.45 ENST00000263463.5
progesterone receptor
chr17_-_19619917 0.45 ENST00000325411.5
ENST00000350657.5
ENST00000433844.2
solute carrier family 47 (multidrug and toxin extrusion), member 2
chr5_+_69321074 0.45 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
small EDRK-rich factor 1B (centromeric)
chr12_+_69864129 0.44 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
fibroblast growth factor receptor substrate 2
chrX_-_21676442 0.44 ENST00000379499.2
kelch-like family member 34
chr2_-_131850951 0.42 ENST00000409185.1
ENST00000389915.3
family with sequence similarity 168, member B
chr1_-_11118896 0.42 ENST00000465788.1
spermidine synthase
chr1_-_1690014 0.41 ENST00000400922.2
ENST00000342348.5
NAD kinase
chr1_+_233765353 0.40 ENST00000366620.1
potassium channel, subfamily K, member 1
chr22_+_22786288 0.40 ENST00000390301.2
immunoglobulin lambda variable 1-36
chr19_-_48059113 0.40 ENST00000391901.3
ENST00000314121.4
ENST00000448976.1
zinc finger protein 541
chr15_-_78933567 0.39 ENST00000261751.3
ENST00000412074.2
cholinergic receptor, nicotinic, beta 4 (neuronal)
chr5_+_135385202 0.38 ENST00000514554.1
transforming growth factor, beta-induced, 68kDa
chr4_+_76649797 0.37 ENST00000538159.1
ENST00000514213.2
USO1 vesicle transport factor
chr5_-_172036436 0.36 ENST00000601856.1
AC027309.1
chr10_+_15074190 0.36 ENST00000428897.1
ENST00000413672.1
oleoyl-ACP hydrolase
chr11_+_64058820 0.36 ENST00000422670.2
potassium channel, subfamily K, member 4
chr22_+_21987005 0.36 ENST00000607942.1
ENST00000425975.1
ENST00000292779.3
coiled-coil domain containing 116
chr1_-_202897724 0.35 ENST00000435533.3
ENST00000367258.1
kelch-like family member 12
chr16_-_21170762 0.35 ENST00000261383.3
ENST00000415178.1
dynein, axonemal, heavy chain 3
chr2_+_946543 0.35 ENST00000308624.5
ENST00000407292.1
syntrophin, gamma 2
chr18_+_10526008 0.34 ENST00000542979.1
ENST00000322897.6
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr5_+_140767452 0.34 ENST00000519479.1
protocadherin gamma subfamily B, 4
chr22_+_22676808 0.33 ENST00000390290.2
immunoglobulin lambda variable 1-51
chr11_+_64058758 0.33 ENST00000538767.1
potassium channel, subfamily K, member 4
chr16_+_2079637 0.33 ENST00000561844.1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr9_-_35650900 0.33 ENST00000259608.3
signaling threshold regulating transmembrane adaptor 1
chr4_-_135248604 0.33 ENST00000515491.1
ENST00000504728.1
ENST00000506638.1
RP11-400D2.2
chr17_-_7218631 0.32 ENST00000577040.2
ENST00000389167.5
ENST00000391950.3
G protein pathway suppressor 2
chr1_+_1115056 0.32 ENST00000379288.3
tubulin tyrosine ligase-like family, member 10
chr1_-_8938736 0.31 ENST00000234590.4
enolase 1, (alpha)
chr17_-_3599327 0.31 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
purinergic receptor P2X, ligand-gated ion channel, 5
chr4_-_52904425 0.31 ENST00000535450.1
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr1_+_11796177 0.31 ENST00000400895.2
ENST00000376629.4
ENST00000376627.2
ENST00000314340.5
ENST00000452018.2
ENST00000510878.1
angiotensin II receptor-associated protein
chr17_-_3599492 0.30 ENST00000435558.1
ENST00000345901.3
purinergic receptor P2X, ligand-gated ion channel, 5
chr7_-_50132801 0.30 ENST00000419417.1
zona pellucida binding protein
chr11_-_34533257 0.30 ENST00000312319.2
E74-like factor 5 (ets domain transcription factor)
chr7_-_50132860 0.30 ENST00000046087.2
zona pellucida binding protein
chr6_-_97285336 0.29 ENST00000229955.3
ENST00000417980.1
G protein-coupled receptor 63
chr17_+_34058639 0.29 ENST00000268864.3
RAS-like, family 10, member B
chr20_+_361261 0.29 ENST00000217233.3
tribbles pseudokinase 3
chr17_-_73905899 0.29 ENST00000409963.3
mitochondrial ribosomal protein L38
chr12_+_54519842 0.28 ENST00000508564.1
RP11-834C11.4
chr12_-_53473136 0.26 ENST00000547837.1
ENST00000301463.4
SPRY domain containing 3
chr19_+_48867652 0.25 ENST00000344846.2
synaptogyrin 4
chr16_+_4364762 0.25 ENST00000262366.3
GLIS family zinc finger 2
chr9_+_17579084 0.25 ENST00000380607.4
SH3-domain GRB2-like 2
chr11_+_20691195 0.25 ENST00000532434.1
NEL-like 1 (chicken)
chr20_-_1306351 0.25 ENST00000381812.1
syndecan binding protein (syntenin) 2
chr9_+_100263912 0.25 ENST00000259365.4
tropomodulin 1
chr16_+_19729586 0.25 ENST00000564186.1
ENST00000541926.1
ENST00000433597.2
IQ motif containing K
chr10_+_96162242 0.24 ENST00000225235.4
TBC1 domain family, member 12
chr3_+_40547483 0.24 ENST00000420891.1
ENST00000314529.6
ENST00000418905.1
zinc finger protein 620
chr1_+_161185032 0.24 ENST00000367992.3
ENST00000289902.1
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr8_-_57232656 0.24 ENST00000396721.2
short chain dehydrogenase/reductase family 16C, member 5
chr10_-_51623203 0.24 ENST00000444743.1
ENST00000374065.3
ENST00000374064.3
ENST00000260867.4
translocase of inner mitochondrial membrane 23 homolog (yeast)
chr3_+_38080691 0.24 ENST00000308059.6
ENST00000346219.3
ENST00000452631.2
deleted in lung and esophageal cancer 1
chr20_-_1306391 0.23 ENST00000339987.3
syndecan binding protein (syntenin) 2
chr1_+_45805342 0.23 ENST00000372090.5
target of EGR1, member 1 (nuclear)
chr5_-_2751762 0.23 ENST00000302057.5
ENST00000382611.6
iroquois homeobox 2
chr16_-_74455290 0.23 ENST00000339953.5
C-type lectin domain family 18, member B
chr1_-_11907829 0.23 ENST00000376480.3
natriuretic peptide A
chr10_+_104678032 0.23 ENST00000369878.4
ENST00000369875.3
cyclin M2
chr12_+_108523133 0.22 ENST00000547525.1
WSC domain containing 2
chr1_+_11796126 0.22 ENST00000376637.3
angiotensin II receptor-associated protein
chr7_+_129074266 0.22 ENST00000249344.2
ENST00000435494.2
striatin interacting protein 2
chr4_-_40859132 0.21 ENST00000543538.1
ENST00000502841.1
ENST00000504305.1
ENST00000513516.1
ENST00000510670.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr19_+_11546440 0.21 ENST00000589126.1
ENST00000588269.1
ENST00000587509.1
ENST00000592741.1
ENST00000593101.1
ENST00000587327.1
protein kinase C substrate 80K-H
chr9_-_111619239 0.21 ENST00000374667.3
actin-like 7B
chr20_-_48530230 0.21 ENST00000422556.1
spermatogenesis associated 2
chr9_+_102668915 0.21 ENST00000259400.6
ENST00000531035.1
ENST00000525640.1
ENST00000534052.1
ENST00000526607.1
syntaxin 17
chr15_-_77988485 0.21 ENST00000561030.1
leucine rich repeat and Ig domain containing 1
chr16_+_333152 0.21 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
protein disulfide isomerase family A, member 2
chr11_-_62783303 0.20 ENST00000336232.2
ENST00000430500.2
solute carrier family 22 (organic anion transporter), member 8
chr7_-_4901625 0.20 ENST00000404991.1
poly(A) polymerase beta (testis specific)
chr12_-_39300071 0.20 ENST00000550863.1
copine VIII
chr6_-_41122063 0.20 ENST00000426005.2
ENST00000437044.2
ENST00000373127.4
triggering receptor expressed on myeloid cells-like 1
chr3_+_49059038 0.20 ENST00000451378.2
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr8_+_25316707 0.20 ENST00000380665.3
cell division cycle associated 2
chr5_+_892745 0.20 ENST00000166345.3
thyroid hormone receptor interactor 13
chr11_-_108422926 0.20 ENST00000428840.1
ENST00000526312.1
exophilin 5
chr4_-_5894777 0.19 ENST00000324989.7
collapsin response mediator protein 1
chr2_+_208527094 0.19 ENST00000429730.1
AC079767.4
chr3_-_128369643 0.19 ENST00000296255.3
ribophorin I
chr9_+_138628365 0.19 ENST00000491806.2
ENST00000488444.2
ENST00000490355.2
ENST00000263604.3
potassium channel, subfamily T, member 1
chr11_+_111126707 0.19 ENST00000280325.4
chromosome 11 open reading frame 53
chrX_-_84634737 0.19 ENST00000262753.4
premature ovarian failure, 1B
chr10_-_43762329 0.18 ENST00000395810.1
RasGEF domain family, member 1A
chr6_-_136847610 0.18 ENST00000454590.1
ENST00000432797.2
microtubule-associated protein 7
chr20_+_32581525 0.18 ENST00000246194.3
ENST00000413297.1
RALY heterogeneous nuclear ribonucleoprotein
chr5_-_892648 0.18 ENST00000483173.1
ENST00000435709.2
bromodomain containing 9
chr11_-_64511789 0.18 ENST00000419843.1
ENST00000394430.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr15_+_45422178 0.17 ENST00000389037.3
ENST00000558322.1
dual oxidase 1
chr11_-_18656028 0.17 ENST00000336349.5
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr20_+_32581452 0.17 ENST00000375114.3
ENST00000448364.1
RALY heterogeneous nuclear ribonucleoprotein
chr4_-_56502451 0.17 ENST00000511469.1
ENST00000264218.3
neuromedin U
chr11_-_8985927 0.16 ENST00000528117.1
ENST00000309134.5
TMEM9 domain family, member B
chr19_-_47551836 0.16 ENST00000253047.6
transmembrane protein 160
chr3_-_196242233 0.16 ENST00000397537.2
single-pass membrane protein with coiled-coil domains 1
chrX_-_63615297 0.16 ENST00000374852.3
ENST00000453546.1
myotubularin related protein 8
chr7_-_44179972 0.16 ENST00000446581.1
myosin, light chain 7, regulatory
chr8_+_144099914 0.16 ENST00000521699.1
ENST00000520531.1
ENST00000520466.1
ENST00000521003.1
ENST00000522528.1
ENST00000522971.1
ENST00000519611.1
ENST00000521182.1
ENST00000519546.1
ENST00000523847.1
ENST00000522024.1
lymphocyte antigen 6 complex, locus E
chr11_-_8986474 0.16 ENST00000525069.1
TMEM9 domain family, member B
chrX_-_109590174 0.15 ENST00000372054.1
guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
chr5_+_178322893 0.15 ENST00000361362.2
ENST00000520660.1
ENST00000520805.1
ZFP2 zinc finger protein
chr3_+_130150307 0.15 ENST00000512836.1
collagen, type VI, alpha 5
chr17_-_4269768 0.15 ENST00000396981.2
ubiquitin-conjugating enzyme E2G 1
chr14_+_50779029 0.15 ENST00000245448.6
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr16_+_8715536 0.14 ENST00000563958.1
ENST00000381920.3
ENST00000564554.1
methyltransferase like 22
chr4_+_15683404 0.14 ENST00000422728.2
family with sequence similarity 200, member B
chr10_+_104678102 0.14 ENST00000433628.2
cyclin M2
chr19_+_641178 0.14 ENST00000166133.3
fibroblast growth factor 22
chr2_+_54951679 0.14 ENST00000356458.6
echinoderm microtubule associated protein like 6
chr3_+_130613226 0.14 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATPase, Ca++ transporting, type 2C, member 1
chr6_+_33589161 0.14 ENST00000605930.1
inositol 1,4,5-trisphosphate receptor, type 3
chr16_+_8715574 0.13 ENST00000561758.1
methyltransferase like 22
chr17_+_4675175 0.13 ENST00000270560.3
transmembrane 4 L six family member 5
chrX_-_27417088 0.13 ENST00000608735.1
ENST00000422048.1
RP11-268G12.1
chr8_-_6914251 0.13 ENST00000330590.2
defensin, alpha 5, Paneth cell-specific
chr1_-_159880159 0.13 ENST00000599780.1
HCG1995379; Uncharacterized protein
chr22_+_44319648 0.13 ENST00000423180.2
patatin-like phospholipase domain containing 3
chr7_-_31380502 0.13 ENST00000297142.3
neuronal differentiation 6
chr3_-_10749696 0.13 ENST00000397077.1
ATPase, Ca++ transporting, plasma membrane 2
chr22_+_22599075 0.13 ENST00000403807.3
pre-B lymphocyte 1
chr12_+_11802753 0.12 ENST00000396373.4
ets variant 6
chr17_-_39140549 0.12 ENST00000377755.4
keratin 40
chr15_+_45422131 0.12 ENST00000321429.4
dual oxidase 1
chr3_+_130613001 0.12 ENST00000504948.1
ENST00000513801.1
ENST00000505072.1
ATPase, Ca++ transporting, type 2C, member 1
chr15_-_94443820 0.12 ENST00000557481.2
CTD-3049M7.1
chr16_-_74734742 0.12 ENST00000308807.7
ENST00000573267.1
mixed lineage kinase domain-like
chr22_+_22599189 0.12 ENST00000302273.2
pre-B lymphocyte 1
chr16_+_2022036 0.12 ENST00000568546.1
transducin (beta)-like 3
chr22_+_23040274 0.12 ENST00000390306.2
immunoglobulin lambda variable 2-23
chr17_-_4269920 0.12 ENST00000572484.1
ubiquitin-conjugating enzyme E2G 1
chr22_+_38864041 0.12 ENST00000216014.4
ENST00000409006.3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr11_-_62783276 0.12 ENST00000535878.1
ENST00000545207.1
solute carrier family 22 (organic anion transporter), member 8
chr19_-_10230540 0.12 ENST00000589454.1
eukaryotic translation initiation factor 3, subunit G
chr9_+_4985016 0.11 ENST00000539801.1
Janus kinase 2
chr19_+_50936142 0.11 ENST00000357701.5
myosin binding protein C, fast type
chr19_-_18717627 0.11 ENST00000392386.3
cytokine receptor-like factor 1
chr16_+_215965 0.11 ENST00000356815.3
hemoglobin, mu

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.3 1.6 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.3 1.0 GO:0048627 myoblast development(GO:0048627)
0.2 1.5 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.2 0.6 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.2 0.7 GO:0050976 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.2 4.2 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.1 0.9 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 1.0 GO:1903826 arginine transmembrane transport(GO:1903826)
0.1 0.5 GO:2001170 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) negative regulation of ATP biosynthetic process(GO:2001170)
0.1 0.5 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1 0.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 4.3 GO:2000810 regulation of bicellular tight junction assembly(GO:2000810)
0.1 1.6 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.1 0.4 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 0.3 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.1 0.7 GO:0033152 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.6 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.2 GO:0033025 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type I hypersensitivity(GO:0001812) positive regulation of type II hypersensitivity(GO:0002894) positive regulation of mast cell cytokine production(GO:0032765) mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 0.2 GO:1900075 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.1 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.7 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 0.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 0.2 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.1 2.1 GO:0006972 hyperosmotic response(GO:0006972)
0.1 0.8 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.4 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 0.3 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.2 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 0.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.4 GO:0046618 drug export(GO:0046618)
0.1 0.3 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.3 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.0 0.3 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 0.3 GO:0042335 cuticle development(GO:0042335)
0.0 0.2 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.0 0.2 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.8 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.4 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.1 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.0 0.1 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.0 0.1 GO:0006533 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.0 0.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.5 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.1 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.5 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0 0.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:1902728 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.4 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.5 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.4 GO:0014029 neural crest formation(GO:0014029)
0.0 0.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.6 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.6 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.3 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.0 GO:0006566 threonine metabolic process(GO:0006566)
0.0 0.3 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 0.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.3 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.1 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.4 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.8 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.7 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.6 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.6 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.3 0.9 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 0.7 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.2 0.6 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.2 1.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.2 0.7 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.7 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.4 GO:0004766 spermidine synthase activity(GO:0004766)
0.1 1.0 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 0.3 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.5 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.4 GO:0016295 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.1 0.8 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.5 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.1 0.4 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.1 0.8 GO:0004645 phosphorylase activity(GO:0004645)
0.1 0.8 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.6 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.3 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 1.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863)
0.0 0.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 1.1 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.4 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.9 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 1.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.0 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 1.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 3.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.1 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 2.1 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.4 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.0 0.6 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels