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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for GCM2

Z-value: 0.53

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Transcription factors associated with GCM2

Gene Symbol Gene ID Gene Info
GCM2
ENSG00000124827.6 glial cells missing transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCM2hg19_v2_chr6_-_10882174_108822740.174.1e-01Click!

Activity profile of GCM2 motif

Sorted Z-values of GCM2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_32264356 0.57 ENST00000452755.2
SPOCD1
SPOC domain containing 1
chr9_+_72658490 0.56 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr11_-_118023490 0.38 ENST00000324727.4
SCN4B
sodium channel, voltage-gated, type IV, beta subunit
chr6_-_32077078 0.37 ENST00000479795.1
TNXB
tenascin XB
chr3_-_79068594 0.37 ENST00000436010.2
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr19_+_19496728 0.36 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr6_+_7107830 0.33 ENST00000379933.3
RREB1
ras responsive element binding protein 1
chr6_+_7107999 0.33 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
RREB1
ras responsive element binding protein 1
chr11_-_72433346 0.32 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr18_+_3449695 0.32 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr16_+_28996364 0.32 ENST00000564277.1
LAT
linker for activation of T cells
chr6_+_7108210 0.31 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
RREB1
ras responsive element binding protein 1
chr21_+_27011584 0.29 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
JAM2
junctional adhesion molecule 2
chr15_-_93199069 0.29 ENST00000327355.5
FAM174B
family with sequence similarity 174, member B
chrX_-_71526813 0.28 ENST00000246139.5
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr18_+_55102917 0.28 ENST00000491143.2
ONECUT2
one cut homeobox 2
chr22_+_31489344 0.27 ENST00000404574.1
SMTN
smoothelin
chr7_-_44365020 0.27 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr13_-_28194541 0.26 ENST00000316334.3
LNX2
ligand of numb-protein X 2
chr19_+_44085189 0.26 ENST00000562365.2
PINLYP
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr19_-_51531272 0.26 ENST00000319720.7
KLK11
kallikrein-related peptidase 11
chr15_+_78632666 0.25 ENST00000299529.6
CRABP1
cellular retinoic acid binding protein 1
chr4_+_95972822 0.25 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr19_-_51530916 0.24 ENST00000594768.1
KLK11
kallikrein-related peptidase 11
chr14_-_67982146 0.24 ENST00000557779.1
ENST00000557006.1
TMEM229B
transmembrane protein 229B
chr2_-_220408430 0.24 ENST00000243776.6
CHPF
chondroitin polymerizing factor
chr11_-_62689046 0.23 ENST00000306960.3
ENST00000543973.1
CHRM1
cholinergic receptor, muscarinic 1
chr9_-_127263265 0.23 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr14_-_21566731 0.23 ENST00000360947.3
ZNF219
zinc finger protein 219
chr22_+_37447771 0.22 ENST00000402077.3
ENST00000403888.3
ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr1_+_20878932 0.22 ENST00000332947.4
FAM43B
family with sequence similarity 43, member B
chr1_+_28199047 0.22 ENST00000373925.1
ENST00000328928.7
ENST00000373927.3
ENST00000427466.1
ENST00000442118.1
ENST00000373921.3
THEMIS2
thymocyte selection associated family member 2
chrX_+_46937745 0.22 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chr14_-_21567009 0.22 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
ZNF219
zinc finger protein 219
chr14_+_104604916 0.22 ENST00000423312.2
KIF26A
kinesin family member 26A
chr7_-_5463175 0.22 ENST00000399537.4
ENST00000430969.1
TNRC18
trinucleotide repeat containing 18
chr8_-_145559943 0.21 ENST00000332135.4
SCRT1
scratch family zinc finger 1
chr1_+_43824669 0.21 ENST00000372462.1
CDC20
cell division cycle 20
chr14_+_75536280 0.21 ENST00000238686.8
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr19_+_36208877 0.21 ENST00000420124.1
ENST00000222270.7
ENST00000341701.1
KMT2B
Histone-lysine N-methyltransferase 2B
chr1_+_15272271 0.20 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr1_+_43824577 0.20 ENST00000310955.6
CDC20
cell division cycle 20
chr14_+_75536335 0.20 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr15_+_40861487 0.20 ENST00000315616.7
ENST00000559271.1
RPUSD2
RNA pseudouridylate synthase domain containing 2
chr8_+_37553261 0.20 ENST00000331569.4
ZNF703
zinc finger protein 703
chr3_+_137490748 0.20 ENST00000478772.1
RP11-2A4.3
RP11-2A4.3
chr11_+_86511549 0.20 ENST00000533902.2
PRSS23
protease, serine, 23
chr17_+_1646130 0.19 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr6_+_37787704 0.19 ENST00000474522.1
ZFAND3
zinc finger, AN1-type domain 3
chr14_-_59932044 0.19 ENST00000395116.1
GPR135
G protein-coupled receptor 135
chr1_-_223537401 0.19 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
SUSD4
sushi domain containing 4
chr11_+_86511569 0.19 ENST00000441050.1
PRSS23
protease, serine, 23
chr19_-_46288917 0.19 ENST00000537879.1
ENST00000596586.1
ENST00000595946.1
DMWD
AC011530.4
dystrophia myotonica, WD repeat containing
Uncharacterized protein
chr14_-_67981916 0.19 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chrX_-_71526999 0.19 ENST00000453707.2
ENST00000373619.3
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr7_-_105319536 0.18 ENST00000477775.1
ATXN7L1
ataxin 7-like 1
chr6_-_32077100 0.18 ENST00000375244.3
ENST00000375247.2
TNXB
tenascin XB
chr1_+_46640750 0.18 ENST00000372003.1
TSPAN1
tetraspanin 1
chr15_+_43809797 0.18 ENST00000399453.1
ENST00000300231.5
MAP1A
microtubule-associated protein 1A
chr7_-_151329416 0.18 ENST00000418337.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr15_-_45670924 0.18 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr19_+_6361754 0.17 ENST00000597326.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr11_-_5345582 0.17 ENST00000328813.2
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr11_+_7597639 0.17 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_+_150869023 0.17 ENST00000448324.1
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr7_-_27169801 0.17 ENST00000511914.1
HOXA4
homeobox A4
chr1_+_237205476 0.17 ENST00000366574.2
RYR2
ryanodine receptor 2 (cardiac)
chr17_-_10017864 0.16 ENST00000323816.4
GAS7
growth arrest-specific 7
chr19_-_5720248 0.16 ENST00000360614.3
LONP1
lon peptidase 1, mitochondrial
chr5_-_176738883 0.16 ENST00000513169.1
ENST00000423571.2
ENST00000502529.1
ENST00000427908.2
MXD3
MAX dimerization protein 3
chr14_-_67981870 0.16 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr7_-_98467489 0.16 ENST00000416379.2
TMEM130
transmembrane protein 130
chr20_+_44420570 0.15 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr19_-_19626351 0.15 ENST00000585580.3
TSSK6
testis-specific serine kinase 6
chr5_+_176560007 0.15 ENST00000510954.1
ENST00000354179.4
NSD1
nuclear receptor binding SET domain protein 1
chrX_-_7066159 0.14 ENST00000486446.2
ENST00000412827.2
ENST00000424830.2
ENST00000381077.5
ENST00000540122.1
HDHD1
haloacid dehalogenase-like hydrolase domain containing 1
chr16_+_2564254 0.14 ENST00000565223.1
ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr22_-_37545972 0.14 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chr19_+_6361795 0.14 ENST00000596149.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr7_+_139478030 0.14 ENST00000425687.1
ENST00000263552.6
ENST00000438104.1
ENST00000336425.5
TBXAS1
thromboxane A synthase 1 (platelet)
chr20_+_44420617 0.14 ENST00000449078.1
ENST00000456939.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr19_-_51531210 0.14 ENST00000391804.3
KLK11
kallikrein-related peptidase 11
chr7_-_36764004 0.14 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr1_+_156105878 0.14 ENST00000508500.1
LMNA
lamin A/C
chr19_+_41222998 0.14 ENST00000263370.2
ITPKC
inositol-trisphosphate 3-kinase C
chr12_-_322504 0.14 ENST00000424061.2
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr9_-_124976154 0.13 ENST00000482062.1
LHX6
LIM homeobox 6
chr9_-_124976185 0.13 ENST00000464484.2
LHX6
LIM homeobox 6
chr19_+_6361841 0.13 ENST00000596605.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chrX_+_122318224 0.13 ENST00000542149.1
GRIA3
glutamate receptor, ionotropic, AMPA 3
chr17_-_8021710 0.13 ENST00000380149.1
ENST00000448843.2
ALOXE3
arachidonate lipoxygenase 3
chr7_+_150782945 0.13 ENST00000463381.1
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr8_-_98290087 0.13 ENST00000322128.3
TSPYL5
TSPY-like 5
chr5_+_140345820 0.13 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr16_-_2059797 0.13 ENST00000563630.1
ZNF598
zinc finger protein 598
chr11_-_9113093 0.12 ENST00000450649.2
SCUBE2
signal peptide, CUB domain, EGF-like 2
chr12_+_50344516 0.12 ENST00000199280.3
ENST00000550862.1
AQP2
aquaporin 2 (collecting duct)
chr19_+_6361440 0.12 ENST00000245816.4
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr5_+_82767284 0.12 ENST00000265077.3
VCAN
versican
chr19_+_55014085 0.12 ENST00000351841.2
LAIR2
leukocyte-associated immunoglobulin-like receptor 2
chr9_-_99381660 0.12 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr19_+_55014013 0.12 ENST00000301202.2
LAIR2
leukocyte-associated immunoglobulin-like receptor 2
chr20_-_60982330 0.12 ENST00000279101.5
CABLES2
Cdk5 and Abl enzyme substrate 2
chrX_-_77225135 0.12 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr7_-_36764142 0.12 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr3_+_186383741 0.12 ENST00000232003.4
HRG
histidine-rich glycoprotein
chrX_+_12156582 0.12 ENST00000380682.1
FRMPD4
FERM and PDZ domain containing 4
chr19_+_639895 0.12 ENST00000586042.2
ENST00000215530.5
FGF22
fibroblast growth factor 22
chr9_+_131873659 0.11 ENST00000452489.2
ENST00000347048.4
ENST00000357197.4
ENST00000445241.1
ENST00000355007.3
ENST00000414331.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr6_-_31864977 0.11 ENST00000395728.3
ENST00000375528.4
EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr5_+_82767487 0.11 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr15_-_88799384 0.11 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr14_-_60097297 0.11 ENST00000395090.1
RTN1
reticulon 1
chr22_-_24181174 0.11 ENST00000318109.7
ENST00000406855.3
ENST00000404056.1
ENST00000476077.1
DERL3
derlin 3
chr17_+_17206635 0.11 ENST00000389022.4
NT5M
5',3'-nucleotidase, mitochondrial
chr14_-_65409438 0.10 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr5_+_122847908 0.10 ENST00000511130.2
ENST00000512718.3
CSNK1G3
casein kinase 1, gamma 3
chr2_-_220252603 0.10 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr16_-_2059748 0.10 ENST00000562103.1
ENST00000431526.1
ZNF598
zinc finger protein 598
chrX_-_77582980 0.10 ENST00000373304.3
CYSLTR1
cysteinyl leukotriene receptor 1
chr12_-_50222187 0.10 ENST00000335999.6
NCKAP5L
NCK-associated protein 5-like
chr8_+_117950422 0.10 ENST00000378279.3
AARD
alanine and arginine rich domain containing protein
chr6_-_31239846 0.10 ENST00000415537.1
ENST00000376228.5
ENST00000383329.3
HLA-C
major histocompatibility complex, class I, C
chr16_+_24857309 0.10 ENST00000565769.1
ENST00000449109.2
ENST00000424767.2
ENST00000545376.1
ENST00000569520.1
SLC5A11
solute carrier family 5 (sodium/inositol cotransporter), member 11
chr5_+_159343688 0.10 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr8_+_20054878 0.10 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr19_-_55954230 0.10 ENST00000376325.4
SHISA7
shisa family member 7
chr17_+_7338737 0.10 ENST00000323206.1
ENST00000396568.1
TMEM102
transmembrane protein 102
chr4_-_147443043 0.10 ENST00000394059.4
ENST00000502607.1
ENST00000335472.7
ENST00000432059.2
ENST00000394062.3
SLC10A7
solute carrier family 10, member 7
chr1_-_223537475 0.09 ENST00000344029.6
ENST00000494793.2
ENST00000366878.4
ENST00000366877.3
SUSD4
sushi domain containing 4
chr1_+_895930 0.09 ENST00000338591.3
KLHL17
kelch-like family member 17
chr7_-_44365216 0.09 ENST00000358707.3
ENST00000457475.1
ENST00000440254.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr4_-_153274078 0.09 ENST00000263981.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr6_+_46761118 0.09 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr8_-_144897549 0.09 ENST00000356994.2
ENST00000320476.3
SCRIB
scribbled planar cell polarity protein
chr15_+_78799895 0.09 ENST00000408962.2
ENST00000388988.4
ENST00000360519.3
HYKK
hydroxylysine kinase
chr7_+_70597109 0.09 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr11_-_9113137 0.09 ENST00000520467.1
ENST00000309263.3
ENST00000457346.2
SCUBE2
signal peptide, CUB domain, EGF-like 2
chr19_+_51293672 0.08 ENST00000270593.1
ENST00000270594.3
ACPT
acid phosphatase, testicular
chr5_-_160975130 0.08 ENST00000274547.2
ENST00000520240.1
ENST00000517901.1
ENST00000353437.6
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr11_+_73882144 0.08 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr15_+_89164520 0.08 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr12_+_15125954 0.08 ENST00000266395.2
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr15_+_78799948 0.08 ENST00000566332.1
HYKK
hydroxylysine kinase
chr16_+_3194211 0.08 ENST00000428155.1
CASP16
caspase 16, apoptosis-related cysteine peptidase (putative)
chr19_-_18653781 0.08 ENST00000596558.2
ENST00000453489.2
FKBP8
FK506 binding protein 8, 38kDa
chr11_-_83393457 0.08 ENST00000404783.3
DLG2
discs, large homolog 2 (Drosophila)
chr10_-_99531709 0.08 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr11_-_83393429 0.08 ENST00000426717.2
DLG2
discs, large homolog 2 (Drosophila)
chr5_+_177027101 0.08 ENST00000029410.5
ENST00000510761.1
ENST00000505468.1
B4GALT7
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
chr11_-_61197480 0.08 ENST00000439958.3
ENST00000394888.4
CPSF7
cleavage and polyadenylation specific factor 7, 59kDa
chr16_-_12009833 0.08 ENST00000420576.2
GSPT1
G1 to S phase transition 1
chr14_-_77737543 0.08 ENST00000298352.4
NGB
neuroglobin
chr15_-_89010607 0.08 ENST00000312475.4
MRPL46
mitochondrial ribosomal protein L46
chr5_+_82767583 0.08 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr1_-_159893507 0.08 ENST00000368096.1
TAGLN2
transgelin 2
chr12_+_56390964 0.08 ENST00000356124.4
ENST00000266971.3
ENST00000394115.2
ENST00000547586.1
ENST00000552258.1
ENST00000548274.1
ENST00000546833.1
SUOX
sulfite oxidase
chr4_-_74864386 0.08 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr16_+_30751953 0.08 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr10_-_102790852 0.08 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr3_+_42727011 0.07 ENST00000287777.4
KLHL40
kelch-like family member 40
chr15_-_93632421 0.07 ENST00000329082.7
RGMA
repulsive guidance molecule family member a
chrX_+_122318318 0.07 ENST00000371251.1
ENST00000371256.5
GRIA3
glutamate receptor, ionotropic, AMPA 3
chr16_+_71392616 0.07 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr19_-_38878632 0.07 ENST00000586599.1
ENST00000334928.6
ENST00000587676.1
GGN
gametogenetin
chr11_-_61197187 0.07 ENST00000449811.1
ENST00000413232.1
ENST00000340437.4
ENST00000539952.1
ENST00000544585.1
ENST00000450000.1
CPSF7
cleavage and polyadenylation specific factor 7, 59kDa
chr16_+_28996572 0.07 ENST00000360872.5
ENST00000566177.1
ENST00000354453.4
LAT
linker for activation of T cells
chr18_-_29264669 0.07 ENST00000306851.5
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr5_+_139493665 0.07 ENST00000331327.3
PURA
purine-rich element binding protein A
chr15_+_89010923 0.07 ENST00000353598.6
MRPS11
mitochondrial ribosomal protein S11
chr14_-_64971288 0.07 ENST00000394715.1
ZBTB25
zinc finger and BTB domain containing 25
chr12_+_5541267 0.07 ENST00000423158.3
NTF3
neurotrophin 3
chr5_+_137774706 0.07 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr21_-_28338732 0.06 ENST00000284987.5
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr19_+_2236509 0.06 ENST00000221494.5
SF3A2
splicing factor 3a, subunit 2, 66kDa
chr1_-_182642017 0.06 ENST00000367557.4
ENST00000258302.4
RGS8
regulator of G-protein signaling 8
chr1_+_150521876 0.06 ENST00000369041.5
ENST00000271643.4
ENST00000538795.1
ADAMTSL4
AL356356.1
ADAMTS-like 4
Protein LOC100996516
chr12_+_81110684 0.06 ENST00000228644.3
MYF5
myogenic factor 5
chr17_+_28256874 0.06 ENST00000541045.1
ENST00000536908.2
EFCAB5
EF-hand calcium binding domain 5
chr12_-_48398104 0.06 ENST00000337299.6
ENST00000380518.3
COL2A1
collagen, type II, alpha 1
chr1_-_156698591 0.06 ENST00000368219.1
ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr1_-_205313304 0.06 ENST00000539253.1
ENST00000607826.1
KLHDC8A
kelch domain containing 8A
chr3_+_35681081 0.06 ENST00000428373.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr13_-_47471155 0.06 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr9_-_127269661 0.06 ENST00000373588.4
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr14_+_24769043 0.06 ENST00000267425.3
ENST00000396802.3
NOP9
NOP9 nucleolar protein
chr20_+_44421137 0.06 ENST00000415790.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr2_-_193059634 0.06 ENST00000392314.1
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr17_-_40833858 0.06 ENST00000332438.4
CCR10
chemokine (C-C motif) receptor 10
chr12_-_49582593 0.06 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr2_-_239140276 0.06 ENST00000334973.4
AC016757.3
Protein LOC151174
chr1_+_155179012 0.06 ENST00000609421.1
MTX1
metaxin 1
chr18_+_3449821 0.06 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr3_-_45837959 0.06 ENST00000353278.4
ENST00000456124.2
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr22_-_30783356 0.06 ENST00000382363.3
RNF215
ring finger protein 215
chr6_+_31021973 0.06 ENST00000570223.1
ENST00000566475.1
ENST00000426185.1
HCG22
HLA complex group 22
chr1_+_156698234 0.06 ENST00000368218.4
ENST00000368216.4
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr3_-_45838011 0.05 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr8_-_67874805 0.05 ENST00000563496.1
TCF24
transcription factor 24
chr14_-_24911448 0.05 ENST00000555355.1
ENST00000553343.1
ENST00000556523.1
ENST00000556249.1
ENST00000538105.2
ENST00000555225.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.4 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.1 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.1 0.4 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1 0.5 GO:0071105 response to interleukin-11(GO:0071105)
0.1 0.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.3 GO:0007538 primary sex determination(GO:0007538)
0.1 0.3 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.2 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.1 0.3 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.0 0.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.8 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.1 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 0.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.1 GO:0044691 tooth eruption(GO:0044691)
0.0 0.3 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.4 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.0 0.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.1 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.1 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.1 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.0 GO:1904339 superior temporal gyrus development(GO:0071109) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 0.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.1 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.0 0.1 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.0 0.0 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.1 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.1 GO:0046078 dUMP metabolic process(GO:0046078)
0.0 0.1 GO:0015824 proline transport(GO:0015824)
0.0 0.1 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0009368 endopeptidase Clp complex(GO:0009368)
0.0 0.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.0 GO:0098855 HCN channel complex(GO:0098855)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 0.2 GO:0070364 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.1 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0 0.2 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.8 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.0 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0005030 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP